scholarly journals Pure redox-sensitive paclitaxel–maleimide prodrug nanoparticles: Endogenous albumin-induced size switching and improved antitumor efficiency

2020 ◽  
Author(s):  
Xinyu Lou ◽  
Dong Zhang ◽  
Hao Ling ◽  
Zhonggui He ◽  
Jin Sun ◽  
...  
Keyword(s):  
Endogenous Albumin

scholarly journals Critical Assessment of the Amerlite Free T4 Assay

1989 ◽  
Vol 26 (6) ◽  
pp. 517-521 ◽  
Author(s):  
C P Reilly ◽  
K J Adamek ◽  
M L Wellby
Keyword(s):  
Late Pregnancy ◽  
Normal Serum ◽  
Critical Assessment ◽  
Oestrogen Therapy ◽  
Clinical Validity ◽  
Free T4 ◽  
Serum Free ◽  
Euthyroid Status ◽  
Enhanced Luminescence ◽  
Endogenous Albumin

The measurement of serum free T4 (FT4) by analogue methods has been severely criticised because the T4 analogue binds to albumin. Amersham have recently introduced a method utilising horseradish peroxidase-labelled-T4 (HRP-T4) designed to overcome this problem and have incorporated it into the Amerlite enhanced luminescence immunoassay system. We have critically evaluated this method for its analytical and clinical validity. Experiments in which anti-albumin was added to normal serum suggested that the HRP-T4 label did not bind to endogenous albumin while the addition of albumin caused no significant change in FT4 concentration. Adding oleic acid up to 5 mmol/L to simulate increased non-esterified fatty acid concentration did not increase the apparent FT4. Serum sampled from subjects independently allocated to clinical groups were compared with an euthyroid group. The untreated hyperthyroid group values were distinctly elevated while the untreated hypothyroid group were appropriately low. Oestrogen therapy, low TBG, familial dysalbuminaemic hyperthyroxinaemia and non-thyroidal illness groups all reflected their euthyroid status, as did pregnancy samples which also showed a tendency to lower values in late pregnancy, consistent with previous observations. In conclusion, the Amerlite FT4 method appears to overcome some of the problems associated with analogue methods. A small survey showed it to be diagnostically valid in a wide variety of clinical states.

Endogenous albumin-mediated delivery of redox-responsive paclitaxel-loaded micelles for targeted cancer therapy

Biomaterials ◽  
2018 ◽  
Vol 183 ◽  
pp. 243-257 ◽  
Author(s):  
Yujie Zhang ◽  
Zhongyuan Guo ◽  
Zhonglian Cao ◽  
Wenxi Zhou ◽  
Yu Zhang ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Targeted Cancer Therapy ◽  
Redox Responsive ◽  
Endogenous Albumin

Transvascular albumin and IgG flux in skin after a continuous 3-h bradykinin infusion

1992 ◽  
Vol 263 (4) ◽  
pp. H1064-H1070
Author(s):  
J. R. Wallace ◽  
D. R. Bell
Keyword(s):  
Plasma Concentration ◽  
Femoral Artery ◽  
Plasma Clearance ◽  
Initial Response ◽  
Sustained Response ◽  
Distribution Space ◽  
Endothelial Gaps ◽  
Ig G ◽  
Endogenous Albumin ◽  
Sustained Increase

Bradykinin (1 microgram/min) was infused into the femoral artery of one hindleg of anesthetized rabbits for 3 h. Measurements of the initial extravascular uptake for labeled albumin and immunoglobulin (Ig) G were compared with measurements of the lymph protein flux for endogenous albumin and IgG. With bradykinin, the initial extravascular uptake for both albumin and IgG, calculated as the 1-h extravascular distribution space at plasma concentration divided by time and expressed as a plasma clearance, was 12 times the control values. For both proteins, the lymph fluxes were not significantly greater than the values for extravascular uptake, indicating that the sustained increase in lymph protein flux was not due to washout of interstitial protein. The extravascular uptake for IgG was approximately 80% of that for albumin in both control and bradykinin animals, suggesting that the sustained response did not change the selectivity between the two proteins. Changes in the extravascular masses of endogenous albumin and IgG suggest that the initial response to bradykinin was a transient formation of endothelial gaps that did not restrict transvascular IgG transport more than albumin.

A quantitative immunocytochemical study of the osmotic opening of the blood-brain barrier to endogenous albumin

1994 ◽  
Vol 23 (12) ◽  
pp. 792-800 ◽  
Author(s):  
A. W. Vorbrodt ◽  
D. H. Dobrogowska ◽  
M. Tarnawski ◽  
A. S. Lossinsky
Keyword(s):  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Immunocytochemical Study ◽  
Blood Brain ◽  
Endogenous Albumin

scholarly journals Dynamics of changes in the indices of the level of endogenous intoxication in patients with alcoholic lesions of the liver

2013 ◽  
Vol 17 (1 (65)) ◽  
pp. 68-70
Author(s):  
P. S. Nazar ◽  
M. M. Levon ◽  
O. I. Osadcha ◽  
O. O. Shevchenko
Keyword(s):  
Peripheral Blood ◽  
Effective Concentration ◽  
Binding Ability ◽  
Toxin Binding ◽  
Endogenous Intoxication ◽  
Medium Mass ◽  
High Level ◽  
Endogenous Albumin

Changes of the indices of the level of endogenous intoxication in 122 patients with an alcoholic lesion of the liver have been studied. It has been established that a high level of endogenous intoxication is identified in these patients connected with a reduction of the concentration of endogenous albumin in the peripheral blood, due to an accumulation of molecules of medium mass, a decrease of the effective concentration of albumin and the toxin-binding ability of albumin.

Influence of Endogenous Albumin Binding on Blood-Material Interactions

1987 ◽  
Vol 516 (1 Blood in Cont) ◽  
pp. 78-95 ◽  
Author(s):  
R. C. EBERHART ◽  
M. S. MUNRO ◽  
J. R. FRAUTSCHI ◽  
M. LUBIN ◽  
F. J. CLUBB ◽  
...  
Keyword(s):  
Albumin Binding ◽  
Endogenous Albumin

A Trojan-Horse Strategy by In Situ Piggybacking onto Endogenous Albumin for Tumor-Specific Neutralization of Oncogenic MicroRNA

ACS Nano ◽  
2021 ◽  
Author(s):  
Gijung Kwak ◽  
Hyosuk Kim ◽  
Jooho Park ◽  
Eun Hye Kim ◽  
Hochung Jang ◽  
...  
Keyword(s):  
Trojan Horse ◽  
Endogenous Albumin
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