Oxidative stress and regulated cell death in Parkinson’s disease

2021 ◽  
Vol 67 ◽  
pp. 101263
Author(s):  
P.A. Dionísio ◽  
J.D. Amaral ◽  
C.M.P. Rodrigues
Keyword(s):  
Oxidative Stress ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cell Death ◽  
Regulated Cell Death

Dieckol, an edible seaweed polyphenol, retards rotenone-induced neurotoxicity and α-synuclein aggregation in human dopaminergic neuronal cells

RSC Advances ◽  
2016 ◽  
Vol 6 (111) ◽  
pp. 110040-110046 ◽  
Author(s):  
Seon-Heui Cha ◽  
Soo-Jin Heo ◽  
You-Jin Jeon ◽  
Sang Myun Park
Keyword(s):  
Oxidative Stress ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cell Death ◽  
Protein Aggregation ◽  
Dopaminergic Neurons ◽  
Neuronal Cells ◽  
Edible Seaweed

Dopaminergic neurons are particularly vulnerable to oxidative stress, which may initiate a cascade of intracellular toxic events that lead to protein aggregation and subsequent cell death, causing Parkinson's disease.

scholarly journals DJ-1-binding compounds prevent oxidative stress-induced cell death and movement defect in Parkinson’s disease model rats

2008 ◽  
Vol 105 (6) ◽  
pp. 2418-2434 ◽  
Author(s):  
Shin Miyazaki ◽  
Takashi Yanagida ◽  
Kana Nunome ◽  
Shizuma Ishikawa ◽  
Masatoshi Inden ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cell Death ◽  
Disease Model

scholarly journals Inflammatory Pathways in Parkinson’s Disease; A BNE Microarray Study

2012 ◽  
Vol 2012 ◽  
pp. 1-16 ◽  
Author(s):  
Pascal. F. Durrenberger ◽  
Edna Grünblatt ◽  
Francesca S. Fernando ◽  
Camelia Maria Monoranu ◽  
Jordan Evans ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cell Death ◽  
Purinergic Receptor ◽  
Neuronal Cell Death ◽  
Neuronal Cell ◽  
Endothelial Activation ◽  
Nitric Oxide Synthase 3 ◽  
Oxide Synthase

The aetiology of Parkinson's disease (PD) is yet to be fully understood but it is becoming more and more evident that neuronal cell death may be multifactorial in essence. The main focus of PD research is to better understand substantia nigra homeostasis disruption, particularly in relation to the wide-spread deposition of the aberrant protein α-synuclein. Microarray technology contributed towards PD research with several studies to date and one gene,ALDH1A1(Aldehyde dehydrogenase 1 family, member A1), consistently reappeared across studies including the present study, highlighting dopamine (DA) metabolism dysfunction resulting in oxidative stress and most probably leading to neuronal cell death. Neuronal cell death leads to increased inflammation through the activation of astrocytes and microglia. Using our dataset, we aimed to isolate some of these pathways so to offer potential novel neuroprotective therapeutic avenues. To that effect our study has focused on the upregulation ofP2X7(purinergic receptor P2X, ligand-gated ion channel, 7) receptor pathway (microglial activation) and on theNOS3(nitric oxide synthase 3) pathway (angiogenesis). In summary, although the exact initiator of striatal DA neuronal cell death remains to be determined, based on our analysis, this event does not remain without consequence. Extracellular ATP and reactive astrocytes appear to be responsible for the activation of microglia which in turn release proinflammatory cytokines contributing further to the parkinsonian condition. In addition to tackling oxidative stress pathways we also suggest to reduce microglial and endothelial activation to support neuronal outgrowth.

Sign in / Sign up

Export Citation Format

Share Document