Synovial Membrane–Derived Mesenchymal Stem Cells Supported by Platelet-Rich Plasma Can Repair Osteochondral Defects in a Rabbit Model

2013 ◽  
Vol 29 (6) ◽  
pp. 1034-1046 ◽  
Author(s):  
Jae-Chul Lee ◽  
Hyun Jin Min ◽  
Hee Jung Park ◽  
Sahnghoon Lee ◽  
Sang Cheol Seong ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Synovial Membrane ◽  
Platelet Rich Plasma ◽  
Rabbit Model ◽  
Osteochondral Defects

scholarly journals Effects of intra-articular injection of mesenchymal stem cells associated with platelet-rich plasma in a rabbit model of osteoarthritis

2016 ◽  
Vol 15 (3) ◽  
Author(s):  
L.C. Hermeto ◽  
R. DeRossi ◽  
R.J. Oliveira ◽  
J.R. Pesarini ◽  
A.C.M.B. Antoniolli-Silva ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Platelet Rich Plasma ◽  
Rabbit Model

Repair of Large Articular Osteochondral Defects Using Hybrid Scaffolds and Bone Marrow-Derived Mesenchymal Stem Cells in a Rabbit Model

2006 ◽  
Vol 0 (0) ◽  
pp. 060706073730036
Author(s):  
Xinxin Shao ◽  
James C.H. Goh ◽  
Dietmar W. Hutmacher ◽  
Eng Hin Lee ◽  
Ge Zigang
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Rabbit Model ◽  
Osteochondral Defects ◽  
Hybrid Scaffolds

Superiority of synovial membrane mesenchymal stem cells in chondrogenesis, osteogenesis, myogenesis and tenogenesis in a rabbit model

Injury ◽  
2020 ◽  
Vol 51 (12) ◽  
pp. 2855-2865 ◽  
Author(s):  
Myrto Bami ◽  
Thomas Sarlikiotis ◽  
Mandy Milonaki ◽  
Myrofora Vikentiou ◽  
Evgenia Konsta ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Synovial Membrane ◽  
Rabbit Model

Synovium-Derived Mesenchymal Stem Cells Encapsulated in a Novel Injectable Gel can Repair Osteochondral Defects in a Rabbit Model

2012 ◽  
Vol 18 (19-20) ◽  
pp. 2173-2186 ◽  
Author(s):  
Jae-Chul Lee ◽  
Sang Young Lee ◽  
Hyun Jin Min ◽  
Sun Ae Han ◽  
Jak Jang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Rabbit Model ◽  
Osteochondral Defects

scholarly journals Are Applied Growth Factors Able to Mimic the Positive Effects of Mesenchymal Stem Cells on the Regeneration of Meniscus in the Avascular Zone?

2014 ◽  
Vol 2014 ◽  
pp. 1-10 ◽  
Author(s):  
Johannes Zellner ◽  
Christian Dirk Taeger ◽  
Markus Schaffer ◽  
J. Camilo Roldan ◽  
Markus Loibl ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Growth Factors ◽  
Platelet Rich Plasma ◽  
Rabbit Model ◽  
Bioactive Substances ◽  
Positive Effects ◽  
Defect Site ◽  
Avascular Zone

Meniscal lesions in the avascular zone are still a problem in traumatology. Tissue Engineering approaches with mesenchymal stem cells (MSCs) showed successful regeneration of meniscal defects in the avascular zone. However, in daily clinical practice, a single stage regenerative treatment would be preferable for meniscus injuries. In particular, clinically applicable bioactive substances or isolated growth factors like platelet-rich plasma (PRP) or bone morphogenic protein 7 (BMP7) are in the focus of interest. In this study, the effects of PRP and BMP7 on the regeneration of avascular meniscal defects were evaluated. In vitro analysis showed that PRP secretes multiple growth factors over a period of 8 days. BMP7 enhances the collagen II deposition in an aggregate culture model of MSCs. However applied to meniscal defects PRP or BMP7 in combination with a hyaluronan collagen composite matrix failed to significantly improve meniscus healing in the avascular zone in a rabbit model after 3 months. Further information of the repair mechanism at the defect site is needed to develop special release systems or carriers for the appropriate application of growth factors to support biological augmentation of meniscus regeneration.

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