scholarly journals Potential role of human-specific genes, human-specific microRNAs and human-specific non-coding regulatory RNAs in the pathogenesis of Systemic Sclerosis and Sjögren's Syndrome

2013 ◽  
Vol 12 (11) ◽  
pp. 1046-1051 ◽  
Author(s):  
Sergio A. Jimenez ◽  
Sonsoles Piera-Velazquez
Keyword(s):  
Systemic Sclerosis ◽  
Sjögren’S Syndrome ◽  
Potential Role ◽  
Sjögren's Syndrome ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Regulatory Rnas ◽  
Human Specific ◽  
Sjögren‘S Syndrome

Potential Role of Epstein-Barr Virus in Sjogren’s Syndrome

1987 ◽  
Vol 13 (2) ◽  
pp. 275-292
Author(s):  
Robert I. Fox ◽  
Todd Chilton ◽  
Susan Scott ◽  
Laurie Benton ◽  
Francis V. Howell ◽  
...  
Keyword(s):  
Sjögren’S Syndrome ◽  
Epstein Barr Virus ◽  
Potential Role ◽  
Sjögren's Syndrome ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Barr Virus ◽  
Epstein Barr ◽  
Sjögren‘S Syndrome

A potential role of the GRO-α/CXCR2 system in Sjögren’s syndrome: regulatory effects of pro-inflammatory cytokines

2012 ◽  
Vol 139 (2) ◽  
pp. 371-379 ◽  
Author(s):  
Sabrina Lisi ◽  
Margherita Sisto ◽  
Dario Domenico Lofrumento ◽  
Massimo D’Amore ◽  
Raffaella Lucro ◽  
...  
Keyword(s):  
Sjögren’S Syndrome ◽  
Inflammatory Cytokines ◽  
Potential Role ◽  
Sjögren's Syndrome ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Regulatory Effects ◽  
Sjögren‘S Syndrome ◽  
Pro Inflammatory Cytokines

scholarly journals AB0609 THE SPECTRUM OF ANTINUCLEAR ANTIBODIES IN PATIENTS WITH SYSTEMIC SCLEROSIS POSITIVE FOR ANTI-U1RNP

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 1600.1-1601
Author(s):  
R. Shayakhmetova ◽  
L. P. Ananyeva ◽  
O. Koneva ◽  
M. Starovoytova ◽  
O. Ovsyannikova ◽  
...  
Keyword(s):  
Systemic Sclerosis ◽  
Sjögren’S Syndrome ◽  
Lupus Erythematosus ◽  
Clinical Picture ◽  
Sjögren's Syndrome ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Normal Limits ◽  
Musculoskeletal Manifestations ◽  
Sjögren‘S Syndrome

Background:Patients with systemic sclerosis positive for anti-U1RNP have special clinical picture and disease progression. The autoimmune profile in this group is poorly understood.Objectives:The purpose of our work was to study the level of major autoantibodies in patients with systemic sclerosis positive for anti-U1RNP.Methods:The study included 80 patients (71 women and 9 men, mean age 44,5±14 years) positive for antibodies to RNP and meeting the criteria of the systemic sclerosis (ACR/EULAR 2013). Patients were examined for autoantibodies: RF, ACCP, ACA, anti-Scl70, anti-RNAP-III, anti-Ro, anti-La, anti-dsDNA, anti-Sm, ACL, anti-Jo1. 44 patients were examined in dynamics in 24 months.Results:In the study group the clinical picture was dominated by inflammatory musculoskeletal lesions (synovitis and myopathy), skin manifestations were poorly expressed. Interstitial lung disease was detected in 68% of cases. Overlaps (34%) with other rheumatic diseases (rheumatoid arthritis, systemic lupus erythematosus) and combination with Sjogren’s syndrome (32.5%) were frequently noted. Other antibodies were often detected: commonly - RF (31%), anti-Ro (38%), anti-dsDNA (42%), rarely - anti-Sm (11%), ACCP (8%), anti-La (8%), ACA (6%), anti-Scl70 (6%), AKL (2%). Anti-Jo1 and anti-RNAP-III were not detected at all. In patients with systemic sclerosis highly-positive for anti-U1RNP (more than 2 upper normal limits) RF, anti-Ro, anti-dsDNA were significantly more common in comparison with low-positive(p=0.00). In dynamics 80% of patients maintained anti-U1RNP, while other autoantibodies were detected with the same frequency. In patients with initially low titer of anti-U1RNP, their disappearance was noted.Conclusion:Patients with systemic sclerosis positive for anti-U1RNP differ in the predominance of inflammatory musculoskeletal manifestations and frequent combination with Sjogren’s syndrome and overlaps. Highly positivity for anti-U1RNP is accompanied by a persistent increase in RF, anti-Ro, anti-dsDNADisclosure of Interests:None declared

scholarly journals A Crucial Role of RORγt in the Development of Spontaneous Sialadenitis-like Sjögren’s Syndrome

2014 ◽  
Vol 194 (1) ◽  
pp. 56-67 ◽  
Author(s):  
Mana Iizuka ◽  
Hiroto Tsuboi ◽  
Naomi Matsuo ◽  
Hiromitsu Asashima ◽  
Tomoya Hirota ◽  
...  
Keyword(s):  
Sjögren’S Syndrome ◽  
Crucial Role ◽  
Sjögren's Syndrome ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Sjögren‘S Syndrome

scholarly journals Presence of microchimerism in labial salivary glands in systemic sclerosis but not in Sjögren's syndrome

2002 ◽  
Vol 46 (4) ◽  
pp. 1039-1043 ◽  
Author(s):  
Sélim Aractingi ◽  
Jean Sibilia ◽  
Véronique Meignin ◽  
David Launay ◽  
Eric Hachulla ◽  
...  
Keyword(s):  
Systemic Sclerosis ◽  
Salivary Glands ◽  
Sjögren’S Syndrome ◽  
Sjögren's Syndrome ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Sjögren‘S Syndrome
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