scholarly journals Consensus Report by the Pediatric Acute Lung Injury and Sepsis Investigators and Pediatric Blood and Marrow Transplant Consortium Joint Working Committees on Supportive Care Guidelines for Management of Veno-Occlusive Disease in Children and Adolescents: Part 2—Focus on Ascites, Fluid and Electrolytes, Renal, and Transfusion Issues

2017 ◽  
Vol 23 (12) ◽  
pp. 2023-2033 ◽  
Author(s):  
Kris M. Mahadeo ◽  
Jennifer McArthur ◽  
Roberta H. Adams ◽  
Mohamed Radhi ◽  
Joseph Angelo ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Supportive Care ◽  
Children And Adolescents ◽  
Marrow Transplant ◽  
Occlusive Disease ◽  
Ascites Fluid ◽  
Blood And Marrow Transplant ◽  
Care Guidelines ◽  
Consensus Report

scholarly journals Leukocyte immunoglobulin-like receptor B4 deficiency exacerbates acute lung injury via NF-κB signaling in bone marrow-derived macrophages

2019 ◽  
Vol 39 (6) ◽  
Author(s):  
Tao Qiu ◽  
Jiangqiao Zhou ◽  
Tianyu Wang ◽  
Zhongbao Chen ◽  
Xiaoxiong Ma ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Acute Lung Injury ◽  
Lung Injury ◽  
Stromal Cells ◽  
Marrow Cell ◽  
Marrow Transplant ◽  
Cell Source ◽  
Transplant Model ◽  
Acute Inflammatory Disease

AbstractAcute lung injury (ALI) is an acute inflammatory disease. Leukocyte immunoglobulin-like receptor B4 (LILRB4) is an immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing inhibitory receptor that is implicated in various pathological processes. However, the function of LILRB4 in ALI remains largely unknown. The aim of the present study was to explore the role of LILRB4 in ALI. LILRB4 knockout mice (LILRB4 KO) were used to construct a model of ALI. Bone marrow cell transplantation was used to identify the cell source of the LILRB4 deficiency-aggravated inflammatory response in ALI. The effect on ALI was analyzed by pathological and molecular analyses. Our results indicated that LILRB4 KO exacerbated ALI triggered by LPS. Additionally, LILRB4 deficiency can enhance lung inflammation. According to the results of our bone marrow transplant model, LILRB4 regulates the occurrence and development of ALI by bone marrow-derived macrophages (BMDMs) rather than by stromal cells in the lung. The observed inflammation was mainly due to BMDM-induced NF-κB signaling. In conclusion, our study demonstrates that LILRB4 deficiency plays a detrimental role in ALI-associated BMDM activation by prompting the NF-κB signal pathway.

scholarly journals The importance of early intervention in the treatment of hepatic veno-occlusive disease

2019 ◽  
Vol 8 (2) ◽  
pp. IJH15
Author(s):  
Antonio Pagliuca
Keyword(s):  
Early Intervention ◽  
European Society ◽  
Marrow Transplant ◽  
Occlusive Disease ◽  
College Hospital ◽  
Hematopoietic Stem ◽  
The Past ◽  
Blood And Marrow Transplant ◽  
King's College ◽  
Severity Grading

Antonio Pagliuca is Professor of hematopoietic stem cell transplantation at King’s College London (UK) and medical director at King’s College Hospital where, until last year, he had been the transplant director for the past 24 years. He also has roles within NHS England as national clinical lead for regenerative medicine and is a trustee on both the Anthony Nolan trust (London, UK) and Leukemia UK (London, UK). Here he speaks to Commissioning Editor Jennifer Straiton and discusses the interim results of the DEFIFrance study, recently presented at the European Society for Blood and Marrow Transplant (EBMT), which looked at the real-world use of the European Society for Blood and Marrow Transplant severity grading criteria. The study investigates the use of defibrotide as a treatment of patients with post-transplant hepatic veno-occlusive disease and demonstrates how it can benefit from early intervention.

scholarly journals User-Centered App Design for Acutely Ill Children and Adolescents

2020 ◽  
Vol 37 (6) ◽  
pp. 359-367
Author(s):  
Jacqueline Vaughn ◽  
Nirmish Shah ◽  
Jude Jonassaint ◽  
Nichol Harris ◽  
Sharron Docherty ◽  
...  
Keyword(s):  
Children And Adolescents ◽  
Marrow Transplant ◽  
Medical Professional ◽  
User Centered Design ◽  
Symptom Experience ◽  
Patients Âgés ◽  
Health Technologies ◽  
Blood And Marrow Transplant ◽  
Patient Reported ◽  
User Centered

Background and Objectives: The high level of acceptance and consistent use of smartphones by children and adolescents present new opportunities to monitor and collect health data. For acutely ill children and adolescents, collecting symptom data via smartphone applications (apps) provides patient-reported data that can be collected daily and offers the potential to provide a more comprehensive picture of the symptom experience. The purpose of this study was to employ user-centered design principles and medical professional input in order to obtain feedback and insight into redesigning our Technology Recordings for better Understanding Blood and Marrow Transplant (TRU-PBMT) app. This redesigned app will be used for children and adolescents with cancer or undergoing blood and marrow transplantation. Method: We interviewed six pediatric blood and marrow transplant patients (ages 10-17 years) who had pilot tested the app, and we surveyed 30 pediatric oncology clinicians. Results: Interview feedback from previous app users and survey feedback from clinicians guided the app redesign. We incorporated suggestions to make the app more engaging, meaningful, personal, and motivating in order to increase symptom reporting. We added emojis to the symptom tracker, a mood scale, and personalized symptom graphs. Conclusion: Leveraging mobile health technologies may be a useful and acceptable approach to obtain symptom data; however, design and software development needs to be evidenced-based and informed by user needs. Our approach using patient and clinician feedback was valuable in the redesign of the TRU-PBMT app and will contribute to symptom research for acutely ill children and adolescents.

Nanomedicine to advance the treatment of bacteria-induced acute lung injury

2021 ◽  
Author(s):  
Ruonan Su ◽  
Yu Zhang ◽  
Jiabin Zhang ◽  
Haixia Wang ◽  
Yun Luo ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Mortality Rate ◽  
Lung Injury ◽  
Supportive Care ◽  
Effective Treatment ◽  
High Mortality

Bacteria-induced acute lung injury (ALI) is associated with a high mortality rate due to the lack of an effective treatment. Patients often rely on supportive care such as low tidal...

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