High resolution crystal structure of rat long chain hydroxy acid oxidase in complex with the inhibitor 4-carboxy-5-[(4-chlorophenyl)sulfanyl]-1, 2, 3-thiadiazole. Implications for inhibitor specificity and drug design

Biochimie ◽  
2012 ◽  
Vol 94 (5) ◽  
pp. 1172-1179 ◽  
Author(s):  
Zhi-wei Chen ◽  
Caroline Vignaud ◽  
Adil Jaafar ◽  
Bernard Lévy ◽  
Françoise Guéritte ◽  
...  
Keyword(s):  
Crystal Structure ◽  
High Resolution ◽  
Drug Design ◽  
Hydroxy Acid ◽  
Acid Oxidase ◽  
Inhibitor Specificity ◽  
Long Chain

Crystal Structure Analysis of Recombinant Rat Kidney Long Chain Hydroxy Acid Oxidase†,‡

Biochemistry ◽  
2005 ◽  
Vol 44 (5) ◽  
pp. 1521-1531 ◽  
Author(s):  
Louise M. Cunane ◽  
John D. Barton ◽  
Zhi-wei Chen ◽  
K. H. Diêp Lê ◽  
David Amar ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Structure Analysis ◽  
Hydroxy Acid ◽  
Rat Kidney ◽  
Crystal Structure Analysis ◽  
Acid Oxidase ◽  
Long Chain

MD and QM/MM Studies on Long-Chain l-α-Hydroxy Acid Oxidase: Substrate Binding Features and Oxidation Mechanism

2014 ◽  
Vol 118 (20) ◽  
pp. 5406-5417 ◽  
Author(s):  
Yang Cao ◽  
Shuang Han ◽  
Lushan Yu ◽  
Haiyan Qian ◽  
Jian-Zhong Chen
Keyword(s):  
Hydroxy Acid ◽  
Substrate Binding ◽  
Oxidation Mechanism ◽  
Acid Oxidase ◽  
Long Chain

Discovery of pyrazole carboxylic acids as potent inhibitors of rat long chain l-2-hydroxy acid oxidase

2012 ◽  
Vol 22 (13) ◽  
pp. 4341-4347 ◽  
Author(s):  
Dinesh A. Barawkar ◽  
Anish Bandyopadhyay ◽  
Anil Deshpande ◽  
Summon Koul ◽  
Sachin Kandalkar ◽  
...  
Keyword(s):  
Carboxylic Acids ◽  
Hydroxy Acid ◽  
Acid Oxidase ◽  
Long Chain

scholarly journals Potent and Selective Inhibitors of Long Chain l-2-Hydroxy Acid Oxidase Reduced Blood Pressure in DOCA Salt-Treated Rats

2011 ◽  
Vol 2 (12) ◽  
pp. 919-923 ◽  
Author(s):  
Dinesh A. Barawkar ◽  
Ashwin Meru ◽  
Anish Bandyopadhyay ◽  
Abir Banerjee ◽  
Anil M. Deshpande ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Hydroxy Acid ◽  
Acid Oxidase ◽  
Selective Inhibitors ◽  
Long Chain

scholarly journals Methylguanidine Synthase from Rat Kidney Is Identical to Long-Chain L-2-Hydroxy Acid Oxidase

Nephron ◽  
1994 ◽  
Vol 68 (2) ◽  
pp. 279-279 ◽  
Author(s):  
Hisashi Ozasa ◽  
Saburo Horikawa ◽  
Kazuo Ota
Keyword(s):  
Hydroxy Acid ◽  
Rat Kidney ◽  
Acid Oxidase ◽  
Long Chain

High resolution STEM imaging study on high Tc superconductor YBa2CuaO7-x

1988 ◽  
Vol 46 ◽  
pp. 882-883
Author(s):  
H.-J. Ou ◽  
J. M. Cowley
Keyword(s):  
Crystal Structure ◽  
High Resolution ◽  
Grain Boundary ◽  
Strong Field ◽  
Imaging Study ◽  
Structure Defects ◽  
High Tc ◽  
High Tc Superconductor ◽  
Diffraction Patterns ◽  
Lattice Planes

Using the dedicate VG-HB5 STEM microscope, the crystal structure of high Tc superconductor of YBa2Cu3O7-x has been studied via high resolution STEM (HRSTEM) imaging and nanobeam (∽3A) diffraction patterns. Figure 1(a) and 2(a) illustrate the HRSTEM image taken at 10' times magnification along [001] direction and [100] direction, respectively. In figure 1(a), a grain boundary with strong field contrast is seen between two crystal regions A and B. The grain boundary appears to be parallel to a (110) plane, although it is not possible to determine [100] and [001] axes as it is in other regions which contain twin planes [3]. Following the horizontal lattice lines, from left to right across the grain boundary, a lattice bending of ∽4° is noticed. Three extra lattice planes, indicated by arrows, were found to terminate at the grain boundary and form dislocations. It is believed that due to different chemical composition, such structure defects occur during crystal growth. No bending is observed along the vertical lattice lines.

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