Design, synthesis and biological evaluation of N-(4-(2-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)phenyl)-4-oxo-3,4-dihydrophthalazine-1-carboxamide derivatives as novel P-glycoprotein inhibitors reversing multidrug resistance

2019 ◽  
Vol 86 ◽  
pp. 166-175 ◽  
Author(s):  
Qianqian Qiu ◽  
Jiaqi Zhou ◽  
Wei Shi ◽  
Mutta Kairuki ◽  
Wenglong Huang ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
P Glycoprotein ◽  
Glycoprotein Inhibitors ◽  
Synthesis And Biological Evaluation

Design, synthesis and biological evaluation of novel triazole-core reversal agents against P-glycoprotein-mediated multidrug resistance

RSC Advances ◽  
2016 ◽  
Vol 6 (31) ◽  
pp. 25819-25828 ◽  
Author(s):  
Bo Zhang ◽  
Tianxiao Zhao ◽  
Jie Zhou ◽  
Qianqian Qiu ◽  
Yuxuan Dai ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Click Chemistry ◽  
Biological Evaluation ◽  
Glycoprotein P ◽  
Design Synthesis ◽  
Reversal Agents ◽  
P Glycoprotein ◽  
Synthesis And Biological Evaluation

We designed and synthesized a novel series of P-glycoprotein (P-gp)-mediated multidrug resistance (MDR) inhibitors bearing a triazolphenethyl–tetrahydroisoquinoline scaffold through click chemistry.

Synthesis and biological evaluation of thiophenylbenzofuran derivatives as potential P-glycoprotein inhibitors

2020 ◽  
Vol 201 ◽  
pp. 112422
Author(s):  
Chin-Chuan Hung ◽  
Chien-Yu Chen ◽  
Yu-Chieh Wu ◽  
Chien-Fu Huang ◽  
Yu-Chun Huang ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
P Glycoprotein ◽  
Glycoprotein Inhibitors ◽  
Synthesis And Biological Evaluation

Design, synthesis and biological evaluation of stereo- and regioisomers of amino aryl esters as multidrug resistance (MDR) reversers

2019 ◽  
Vol 182 ◽  
pp. 111655 ◽  
Author(s):  
Elisabetta Teodori ◽  
Marialessandra Contino ◽  
Chiara Riganti ◽  
Gianluca Bartolucci ◽  
Laura Braconi ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
Synthesis And Biological Evaluation

Discovery to solve multidrug resistance: Design, synthesis, and biological evaluation of novel agents

2019 ◽  
Vol 352 (10) ◽  
pp. 1900127 ◽  
Author(s):  
Qianqian Qiu ◽  
Wei Shi ◽  
Shiyuan Zhao ◽  
Yan Zhu ◽  
Zhengquan Ding ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Biological Evaluation ◽  
Novel Agents ◽  
Design Synthesis ◽  
Synthesis And Biological Evaluation

Design, synthesis, biological evaluation, NMR and DFT studies of structurally simplified trimethoxy benzamides as selective P-glycoprotein inhibitors: the role of molecular flatness

2016 ◽  
Vol 88 (6) ◽  
pp. 820-831 ◽  
Author(s):  
Angela Stefanachi ◽  
Giuseppe Felice Mangiatordi ◽  
Piero Tardia ◽  
Domenico Alberga ◽  
Francesco Leonetti ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Dft Studies ◽  
Design Synthesis ◽  
P Glycoprotein ◽  
Glycoprotein Inhibitors

scholarly journals Design, Synthesis, and Biological Evaluation of (S)-Valine Thiazole-Derived Cyclic and Noncyclic Peptidomimetic Oligomers as Modulators of Human P-Glycoprotein (ABCB1)

ChemBioChem ◽  
2013 ◽  
Vol 15 (1) ◽  
pp. 157-169 ◽  
Author(s):  
Satyakam Singh ◽  
Nagarajan Rajendra Prasad ◽  
Khyati Kapoor ◽  
Eduardo E. Chufan ◽  
Bhargav A. Patel ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Design Synthesis ◽  
P Glycoprotein ◽  
Synthesis And Biological Evaluation
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