Effect of patchouli (Pogostemon cablin) essential oil on in vitro and in vivo leukocytes behavior in acute inflammatory response

2016 ◽  
Vol 84 ◽  
pp. 1697-1704 ◽  
Author(s):  
Saulo Euclides Silva-Filho ◽  
Luiz Alexandre Marques Wiirzler ◽  
Heitor Augusto Otaviano Cavalcante ◽  
Nancy Sayuri Uchida ◽  
Francielli Maria de Souza Silva-Comar ◽  
...  
Keyword(s):  
Essential Oil ◽  
Inflammatory Response ◽  
Acute Inflammatory Response ◽  
Pogostemon Cablin

scholarly journals Effect of Camphor on the Behavior of Leukocytes In vitro and In vivo in Acute Inflammatory Response

2015 ◽  
Vol 13 (12) ◽  
pp. 2031 ◽  
Author(s):  
SE Silva-Filho ◽  
FM De Souza Silva-Comar ◽  
LAM Wiirzler ◽  
RJ Do Pinho ◽  
R Grespan ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Acute Inflammatory Response

Recombinant P-selectin glycoprotein ligand–1 directly inhibits leukocyte rolling by all 3 selectins in vivo: complete inhibition of rolling is not required for anti-inflammatory effect

Blood ◽  
2003 ◽  
Vol 101 (8) ◽  
pp. 3249-3256 ◽  
Author(s):  
Anne E. R. Hicks ◽  
Sarah L. Nolan ◽  
Victoria C. Ridger ◽  
Paul G. Hellewell ◽  
Keith E. Norman
Keyword(s):  
Inflammatory Response ◽  
Clinical Benefit ◽  
Inflammatory Diseases ◽  
Neutrophil Migration ◽  
Acute Inflammatory Response ◽  
Leukocyte Rolling ◽  
Selectin Ligand ◽  
Inflammatory Effect

AbstractSelectin-dependent leukocyte rolling is one of the earliest steps of an acute inflammatory response and, as such, contributes to many inflammatory diseases. Although inhibiting leukocyte rolling with selectin antagonists is a strategy that promises far-reaching clinical benefit, the perceived value of this strategy has been limited by studies using inactive, weak, or poorly characterized antagonists. Recombinant P-selectin glycoprotein ligand–1–immunoglobulin (rPSGL-Ig) is a recombinant form of the best-characterized selectin ligand (PSGL-1) fused to IgG, and is one of the best prospects in the search for effective selectin antagonists. We have used intravital microscopy to investigate the ability of rPSGL-Ig to influence leukocyte rolling in living blood vessels and find that it can reduce rolling dependent on each of the selectins in vivo. Interestingly, doses of rPSGL-Ig required to reverse pre-existing leukocyte rolling are 30-fold higher than those required to limit inflammation, suggesting additional properties of this molecule. In support of this, we find that rPSGL-Ig can bind the murine chemokine KC and inhibit neutrophil migration toward this chemoattractant in vitro.

7,12-Dimethylbenz(a)anthracene-Induced Myelotoxicity Differs in Mice Selected for High or Low Acute Inflammatory Response

2014 ◽  
Vol 33 (2) ◽  
pp. 130-142 ◽  
Author(s):  
Iana Suly Santos Katz ◽  
Layra Lucy Albuquerque ◽  
Alessandra Paes Suppa ◽  
Débora Mathias de Siqueira ◽  
Cristiano Rossato ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Environmental Pollutants ◽  
Myeloid Cells ◽  
Myeloid Cell ◽  
Phenotypic Selection ◽  
Acute Inflammatory Response ◽  
Aryl Hydrocarbon ◽  
Ahr Gene

Polycyclic aromatic hydrocarbons, such as 7,12-dimethylbenz(a)anthracene (DMBA), are environmental pollutants that exert multiple toxic and carcinogenic effects. Studies showed that these effects are mediated by activation of the aryl hydrocarbon receptor (AhR) and modulated by allelic variants of Ahr gene. Here, we investigated the effects of DMBA treatment in the inflammatory response and bone marrow (BM) hematopoietic function of maximal acute inflammatory response (AIRmax) and minimal acute inflammatory response (AIRmin) heterogeneous mouse lines selected for high and low acute inflammatory responsiveness, respectively. The phenotypic selection resulted in the segregation of the Ahrd and Ahrb1 alleles that confer low and high receptor ligand-binding affinity, respectively, in AIRmax and AIRmin mice. We observed a reduction in BM mature granulocyte population in AIRmin mice 24 hours after DMBA treatment while both blast and immature myeloid cells were increased. Proliferation and differentiation of BM myeloid cells in response to in vitro granulocyte-macrophage colony-stimulating factor stimulus were impaired in AIRmin-treated mice. These DMBA effects on myeloid BM cells (BMCs) affected the in vivo leukocyte migration to an inflammatory site induced by polyacrylamide beads (Biogel P-100, Bio-Rad, France) injection in AIRmin mice. On the other hand, these alterations were not observed in DMBA-treated AIRmax mice. These data indicate that DMBA affects myeloid cell differentiation and inflammatory response and Ahrb1 allele in the genetic background of AIRmin mice contributes to this effect.

scholarly journals In vivo and in vitro evaluation of hydroxyapatite nanoparticle morphology on the acute inflammatory response

Biomaterials ◽  
2016 ◽  
Vol 90 ◽  
pp. 1-11 ◽  
Author(s):  
Shiuli Pujari-Palmer ◽  
Song Chen ◽  
Stefano Rubino ◽  
Hong Weng ◽  
Wei Xia ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Acute Inflammatory Response ◽  
In Vitro Evaluation ◽  
Nanoparticle Morphology

scholarly journals Effect of Lavender (Lavandula angustifolia) Essential Oil on Acute Inflammatory Response

2018 ◽  
Vol 2018 ◽  
pp. 1-10 ◽  
Author(s):  
Gabriel Fernando Esteves Cardia ◽  
Saulo Euclides Silva-Filho ◽  
Expedito Leite Silva ◽  
Nancy Sayuri Uchida ◽  
Heitor Augusto Otaviano Cavalcante ◽  
...  
Keyword(s):  
Essential Oil ◽  
Inflammatory Response ◽  
No Production ◽  
Acute Inflammatory Response ◽  
Paw Edema ◽  
Lavandula Angustifolia ◽  
Edema Formation ◽  
Edema Model ◽  
Anti Inflammatory

Lavandula angustifolia is a plant of Lamiaceae family, with many therapeutic properties and biological activities, such as anticonvulsant, anxiolytic, antioxidant, anti-inflammatory, and antimicrobial activities. The aim of this study was to evaluate the effect of Lavandula angustifolia Mill. essential oil (LEO) on acute inflammatory response. LEO was analyzed using gas chromatography-mass spectrometry (GC-MS) and nuclear magnetic resonance spectroscopy (NMR) methods and showed predominance of 1,8-cineole (39.83%), borneol (22.63%), and camphor (22.12%). LEO at concentrations of 0.5, 1, 3, and 10 μg/ml did not present in vitro cytotoxicity. Additionally, LEO did not stimulate the leukocyte chemotaxis in vitro. The LEO topical application at concentrations of 0.25, 0.5, and 1 mg/ear reduced edema formation, myeloperoxidase (MPO) activity, and nitric oxide (NO) production in croton oil-induced ear edema model. In carrageenan-induced paw edema model, LEO treatment at doses of 75, 100, and 250 mg/kg reduced edema formation, MPO activity, and NO production. In dextran-induced paw edema model, LEO at doses of 75 and 100 mg/kg reduced paw edema and MPO activity. In conclusion, LEO presented anti-inflammatory activity, and the mechanism proposed of LEO seems to be, at least in part, involving the participation of prostanoids, NO, proinflammatory cytokines, and histamine.

scholarly journals Combined In Silico, In Vivo, and In Vitro Studies Shed Insights into the Acute Inflammatory Response in Middle-Aged Mice

PLoS ONE ◽  
2013 ◽  
Vol 8 (7) ◽  
pp. e67419 ◽  
Author(s):  
Rami A. Namas ◽  
John Bartels ◽  
Rosemary Hoffman ◽  
Derek Barclay ◽  
Timothy R. Billiar ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
In Silico ◽  
In Vitro Studies ◽  
Acute Inflammatory Response ◽  
Middle Aged ◽  
Aged Mice

The in vivo and in vitro angiogenic evaluation of the essential oil of Echinophora tournefortii

Planta Medica ◽  
2010 ◽  
Vol 76 (12) ◽  
Author(s):  
B Demirci ◽  
T Kiyan ◽  
A Koparal ◽  
M Kaya ◽  
F Demirci ◽  
...  
Keyword(s):  
Essential Oil

Inhibitory effects of epimedium herb water extract on the inflammatory response in vitro and in vivo

Planta Medica ◽  
2016 ◽  
Vol 81 (S 01) ◽  
pp. S1-S381
Author(s):  
YC Oh ◽  
YH Jeong ◽  
WK Cho ◽  
SJ Lee ◽  
JY Ma
Keyword(s):  
Inflammatory Response ◽  
Water Extract ◽  
Inhibitory Effects

scholarly journals Amelioration of lipid peroxidation in vivo and in vitro by Satureja khozestanica essential oil in alloxan-induced diabetic rats

2014 ◽  
Vol 13 (1) ◽  
Author(s):  
Hassan Ahmadvand ◽  
Majid Tavafi ◽  
Ali Khosrowbeygi ◽  
Gholamreza Shahsavari ◽  
Maryam Hormozi ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Essential Oil ◽  
Diabetic Rats

Neurotrophic Properties of Silexan, an Essential Oil from the Flowers of Lavender-Preclinical Evidence for Antidepressant-Like Properties

2020 ◽  
Vol 54 (01) ◽  
pp. 37-46
Author(s):  
Kristina Friedland ◽  
Giacomo Silani ◽  
Anita Schuwald ◽  
Carola Stockburger ◽  
Egon Koch ◽  
...  
Keyword(s):  
Essential Oil ◽  
Hippocampal Neurons ◽  
Day Treatment ◽  
Neuronal Cell ◽  
Antidepressant Activity ◽  
In Vivo Models ◽  
Antidepressant Effects ◽  
Primary Hippocampal Neurons

Abstract Background Silexan, a special essential oil from flowering tops of lavandula angustifolia, is used to treat subsyndromal anxiety disorders. In a recent clinical trial, Silexan also showed antidepressant effects in patients suffering from mixed anxiety-depression (ICD-10 F41.2). Since preclinical data explaining antidepressant properties of Silexan are missing, we decided to investigate if Silexan also shows antidepressant-like effects in vitro as well as in vivo models. Methods We used the forced swimming test (FST) in rats as a simple behavioral test indicative of antidepressant activity in vivo. As environmental events and other risk factors contribute to depression through converging molecular and cellular mechanisms that disrupt neuronal function and morphology—resulting in dysfunction of the circuitry that is essential for mood regulation and cognitive function—we investigated the neurotrophic properties of Silexan in neuronal cell lines and primary hippocampal neurons. Results The antidepressant activity of Silexan (30 mg/kg BW) in the FST was comparable to the tricyclic antidepressant imipramine (20 mg/kg BW) after 9-day treatment. Silexan triggered neurite outgrowth and synaptogenesis in 2 different neuronal cell models and led to a significant increase in synaptogenesis in primary hippocampal neurons. Silexan led to a significant phosphorylation of protein kinase A and subsequent CREB phosphorylation. Conclusion Taken together, Silexan demonstrates antidepressant-like effects in cellular as well as animal models for antidepressant activity. Therefore, our data provides preclinical evidence for the clinical antidepressant effects of Silexan in patients with mixed depression and anxiety.

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