scholarly journals Icariside II suppresses cervical cancer cell migration through JNK modulated matrix metalloproteinase-2/9 inhibition in vitro and in vivo

2020 ◽  
Vol 125 ◽  
pp. 110013 ◽  
Author(s):  
Ya-Sai Sun ◽  
Kiran Thakur ◽  
Fei Hu ◽  
Carlos L. Cespedes-Acuña ◽  
Jian-Guo Zhang ◽  
...  
2017 ◽  
Vol 38 (3) ◽  
pp. 1561-1568 ◽  
Author(s):  
Xiaoxi Li ◽  
Hong Wang ◽  
Xingxing Du ◽  
Wenna Yu ◽  
Jingwen Jiang ◽  
...  

FEBS Open Bio ◽  
2020 ◽  
Vol 10 (12) ◽  
pp. 2750-2760
Author(s):  
Li Li ◽  
Ruihong Zhang ◽  
Hailei Yang ◽  
Donghua Zhang ◽  
Jiwei Liu ◽  
...  

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Dan Lei ◽  
Wen-Ting Yang ◽  
Peng-Sheng Zheng

AbstractHomeobox B4 (HOXB4), which belongs to the homeobox (HOX) family, possesses transcription factor activity and has a crucial role in stem cell self-renewal and tumorigenesis. However, its biological function and exact mechanism in cervical cancer remain unknown. Here, we found that HOXB4 was markedly downregulated in cervical cancer. We demonstrated that HOXB4 obviously suppressed cervical cancer cell proliferation and tumorigenic potential in nude mice. Additionally, HOXB4-induced cell cycle arrest at the transition from the G0/G1 phase to the S phase. Conversely, loss of HOXB4 promoted cervical cancer cell growth both in vitro and in vivo. Bioinformatics analyses and mechanistic studies revealed that HOXB4 inhibited the activity of the Wnt/β-catenin signaling pathway by direct transcriptional repression of β-catenin. Furthermore, β-catenin re-expression rescued HOXB4-induced cervical cancer cell defects. Taken together, these findings suggested that HOXB4 directly transcriptional repressed β-catenin and subsequently inactivated the Wnt/β-catenin signaling pathway, leading to significant inhibition of cervical cancer cell growth and tumor formation.


2019 ◽  
Vol 34 (10) ◽  
pp. 1085-1093 ◽  
Author(s):  
Chia‐Ming Yeh ◽  
Ming‐Ju Hsieh ◽  
Jia‐Sin Yang ◽  
Shun‐Fa Yang ◽  
Yi‐Ting Chuang ◽  
...  

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Juan Li ◽  
Chen Qi ◽  
Xia Liu ◽  
Changzhong Li ◽  
Jie Chen ◽  
...  

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