scholarly journals Self-developed NF-κB inhibitor 270 protects against LPS-induced acute kidney injury and lung injury through improving inflammation

2022 ◽  
Vol 147 ◽  
pp. 112615
Author(s):  
Yan-yan Yu ◽  
Xiang-qian Li ◽  
Wen-peng Hu ◽  
Shi-chao Cu ◽  
Jia-jia Dai ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Lung Injury ◽  
Kidney Injury

scholarly journals Acute kidney injury in patients with acute lung injury: Impact of fluid accumulation on classification of acute kidney injury and associated outcomes*

2011 ◽  
Vol 39 (12) ◽  
pp. 2665-2671 ◽  
Author(s):  
Kathleen D. Liu ◽  
B. Taylor Thompson ◽  
Marek Ancukiewicz ◽  
Jay S. Steingrub ◽  
Ivor S. Douglas ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Acute Lung Injury ◽  
Lung Injury ◽  
Kidney Injury ◽  
Fluid Accumulation

scholarly journals Premobilization of CD133+ progenitors is associated with attenuated inflammation-induced pulmonary dysfunction following extracorporeal circulation in mice

2020 ◽  
Vol 31 (2) ◽  
pp. 210-220
Author(s):  
Dan Luo ◽  
Xinhao Liu ◽  
Jie Zhang ◽  
Lei Du ◽  
Lin Bai ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Lung Injury ◽  
Bronchoalveolar Lavage ◽  
Lung Tissue ◽  
Extracorporeal Circulation ◽  
Kidney Injury ◽  
Inflammatory Factors ◽  
Pulmonary Dysfunction

Abstract OBJECTIVES Progenitor cells mobilized by granulocyte colony-stimulating factor (G-CSF) have been shown to lessen acute kidney injury induced by extracorporeal circulation (ECC). Both acute kidney injury and lung injury are characterized by endothelial dysfunction. Our goal was to examine whether and how G-CSF-mobilized progenitors with endothelial capacity may help mitigate ECC-induced pulmonary dysfunction. METHODS G-CSF (10 μg/kg/day) was administered subcutaneously to C57BL/6 mice before or at the initiation of the ECC process, after which lung injury was assessed by measuring neutrophils in the fluid from bronchoalveolar lavage and determining the pathological score in lung tissue. CD133+ progenitors were isolated and injected into C57BL/6 mice before ECC in vivo. We incubated the CD133+ cells with pulmonary monocytes or neutrophils isolated from naïve mice in vitro. RESULTS Pretreatment with G-CSF for 2 days significantly decreased the number of neutrophils in the bronchoalveolar lavage fluid, and the pathological score (P < 0.01; n = 5) improved the PaO2/FiO2 ratio [193.4 ± 12.7 (ECC without G-CSF) vs 305.6 ± 22.6 mmHg (ECC with G-CSF); P = 0.03, n = 5] and suppressed neutrophil elastase and tumour necrosis factor-α levels in the circulation; we also observed increases in both circulating and pulmonary populations of CD133+ progenitors. Similar effects were observed in animals pretreated with CD133+ progenitors instead of G-CSF before ECC. The majority of CD133+/CD45− and CD133+/CD45+ progenitors were mobilized in the lung and in the circulation, respectively. Incubating CD133+ progenitors with neutrophils or pulmonary monocytes blocked lipopolysaccharide-induced release of inflammatory factors. CONCLUSIONS Our results suggest that pretreatment of G-CSF attenuates ECC-induced pulmonary dysfunction through inhibiting the inflammatory response in lung tissue and in the circulation with associated premobilization of CD133+ progenitors.

scholarly journals Indoxyl Sulfate as a Mediator Involved in Dysregulation of Pulmonary Aquaporin-5 in Acute Lung Injury Caused by Acute Kidney Injury

2016 ◽  
Vol 18 (1) ◽  
pp. 11 ◽  
Author(s):  
Nozomi Yabuuchi ◽  
Masataka Sagata ◽  
Chika Saigo ◽  
Go Yoneda ◽  
Yuko Yamamoto ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Acute Lung Injury ◽  
Lung Injury ◽  
Kidney Injury ◽  
Indoxyl Sulfate ◽  
Aquaporin 5
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