Variations in the Promoter Region of the Serotonin Transporter Gene and Biased Attention for Emotional Information: A Meta-Analysis

2012 ◽  
Vol 71 (4) ◽  
pp. 373-379 ◽  
Author(s):  
Lee Pergamin-Hight ◽  
Marian J. Bakermans-Kranenburg ◽  
Marinus H. van IJzendoorn ◽  
Yair Bar-Haim
Keyword(s):  
Serotonin Transporter ◽  
Promoter Region ◽  
Meta Analysis ◽  
Serotonin Transporter Gene ◽  
Transporter Gene ◽  
Emotional Information

Associations between serotonin transporter gene promoter region (5-HTTLPR) polymorphism and gaze bias for emotional information.

2011 ◽  
Vol 120 (1) ◽  
pp. 187-197 ◽  
Author(s):  
Christopher G. Beevers ◽  
C. Nathan Marti ◽  
Han-Joo Lee ◽  
Deborah L. Stote ◽  
Robert E. Ferrell ◽  
...  
Keyword(s):  
Serotonin Transporter ◽  
Promoter Region ◽  
Gene Promoter ◽  
Serotonin Transporter Gene ◽  
Transporter Gene ◽  
Emotional Information ◽  
Gaze Bias ◽  
Gene Promoter Region

Association Study and Meta-Analysis of Polymorphisms, Methylation Profiles, and Peripheral mRNA Expression of the Serotonin Transporter Gene in Patients with Alzheimer's Disease

2016 ◽  
Vol 41 (5-6) ◽  
pp. 334-347 ◽  
Author(s):  
Kiyohiro Yamazaki ◽  
Yuta Yoshino ◽  
Takaaki Mori ◽  
Mitsuo Okita ◽  
Taku Yoshida ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Mrna Expression ◽  
Serotonin Transporter ◽  
Promoter Region ◽  
Meta Analysis ◽  
Caucasian Population ◽  
Serotonin Transporter Gene ◽  
Expression Level ◽  
Transporter Gene ◽  
The Relationship

Background/Aim: The aim of this study was to elucidate the relationship between Alzheimer's disease (AD) and the serotonin transporter gene (SLC6A4). Methods: AD subjects (n = 43) and controls (n = 47) were recruited and evaluated. In leukocytes, we evaluated two polymorphisms in SLC6A4, the serotonin transporter length polymorphic region (5-HTT-LPR) and rs25531, as well as methylation rates of the SLC6A4 promoter region and the SLC6A4 mRNA expression level. We also performed a meta-analysis to examine the relationship between the frequency of the L allele and the risk of AD. Results: The distributions of 5-HTT-LPR and rs25531 polymorphisms in AD subjects were not different from those of controls. Although the methylation rates in AD subjects were not significantly different from those of controls, the expression level in AD subjects was significantly higher than in controls. Additionally, the expression level in AD subjects was significantly correlated with apathy. Meta-analysis revealed that the L/L genotype significantly reduced the risk of AD, but only in the Caucasian population. Conclusion: Higher SLC6A4 mRNA expression in leukocytes in AD was associated with apathy regardless of SLC6A4 genotypes and methylation rates of the promoter region. The L/L genotype may reduce the risk of AD in the Caucasian population.

scholarly journals Lack of Association Between Serotonin Transporter Gene (SLC6A4) Promoter Methylation and Amygdala Response During Negative Emotion Processing in Individuals With Alcohol Dependence

2019 ◽  
Vol 54 (3) ◽  
pp. 209-215 ◽  
Author(s):  
Christine Muench ◽  
Audrey Luo ◽  
Katrin Charlet ◽  
Jisoo Lee ◽  
Daniel B Rosoff ◽  
...  
Keyword(s):  
Alcohol Dependence ◽  
Serotonin Transporter ◽  
Promoter Methylation ◽  
Promoter Region ◽  
Serotonin Transporter Gene ◽  
Matching Task ◽  
Transporter Gene ◽  
Healthy Individuals ◽  
Brain Functions ◽  
Amygdala Activation

Abstract Aims Differences in DNA methylation of the serotonin transporter gene (SLC6A4) have been shown to alter SLC6A4 expression and predict brain functions in healthy individuals. This study investigated the association between SLC6A4 promoter methylation and threat-related amygdala activation in individuals with alcohol dependence (AD). Methods Methylation of the SLC6A4 promoter region was assessed using peripheral blood DNA from 45 individuals with AD and 45 healthy controls (HCs). All participants completed an emotional face matching task in a 3-T magnetic resonance imaging (MRI) scanner. Results Results did not reveal any association between SLC6A4 promoter methylation variation and threat-related amygdala activation in HCs or individuals with AD. Furthermore, methylation in the promoter region of SLC6A4 did not significantly differ between the groups. Conclusions Our results do not replicate a previous finding that increased methylation in the promoter region of SLC6A4 is associated with threat-related amygdala activation in healthy individuals and further show that there is no such association in individuals with AD. Given that the number of imaging epigenetics studies on SLC6A4 is very limited to date, these inconsistent results indicate that future research is needed to clarify its association with amygdala reactivity in both healthy and clinical populations.

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