Design, synthesis, and structure–activity relationship study of bicyclic piperazine analogs of indole-3-carboxamides as novel cannabinoid CB1 receptor agonists

Elizabeth M. Moir; Kazuya Yoshiizumi; Jim Cairns; Phillip Cowley; Morag Ferguson; Fiona Jeremiah; Takao Kiyoi; Richard Morphy; Jason Tierney; Grant Wishart; Mark York; James Baker; Jean E. Cottney; Andrea K. Houghton; Petula McPhail; Andrew Osprey; Glenn Walker; Julia M. Adam

doi:10.1016/j.bmcl.2010.10.061

Design, synthesis, and structure–activity relationship study of bicyclic piperazine analogs of indole-3-carboxamides as novel cannabinoid CB1 receptor agonists

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2010.10.061 ◽

2010 ◽

Vol 20 (24) ◽

pp. 7327-7330 ◽

Cited By ~ 16

Author(s):

Elizabeth M. Moir ◽

Kazuya Yoshiizumi ◽

Jim Cairns ◽

Phillip Cowley ◽

Morag Ferguson ◽

...

Keyword(s):

Structure Activity Relationship ◽

Cb1 Receptor ◽

Activity Relationship ◽

Cannabinoid Cb1 Receptor ◽

Design Synthesis ◽

Receptor Agonists ◽

Structure Activity ◽

Relationship Study

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Design, synthesis, and structure–activity relationship study of conformationally constrained analogs of indole-3-carboxamides as novel CB1 cannabinoid receptor agonists

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2010.06.067 ◽

2010 ◽

Vol 20 (16) ◽

pp. 4918-4921 ◽

Cited By ~ 12

Author(s):

Takao Kiyoi ◽

Mark York ◽

Stuart Francis ◽

Darren Edwards ◽

Glenn Walker ◽

...

Keyword(s):

Cannabinoid Receptor ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Design Synthesis ◽

Conformationally Constrained ◽

Receptor Agonists ◽

Cb1 Cannabinoid Receptor ◽

Structure Activity ◽

Relationship Study

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Design, synthesis, biological evaluation and structure-activity relationship study of quinazolin-4(3H)-one derivatives as novel USP7 inhibitors

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2021.113291 ◽

2021 ◽

pp. 113291

Author(s):

Peng Li ◽

Ying Liu ◽

Hua Yang ◽

Hong-Min Liu

Keyword(s):

Structure Activity Relationship ◽

Biological Evaluation ◽

Activity Relationship ◽

Design Synthesis ◽

Structure Activity ◽

Relationship Study

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Design, Synthesis and Quantitative Structure-Activity Relationship Study of N-(3-Oxo-3,4-dihydro-2H-benzo(1,4)oxazine-7-carbonyl)guanidine Derivatives as Potent Na/H Exchange Inhibitors.

Chemical and Pharmaceutical Bulletin ◽

10.1248/cpb.45.1975 ◽

1997 ◽

Vol 45 (12) ◽

pp. 1975-1983 ◽

Cited By ~ 3

Author(s):

Takeshi YAMAMOTO ◽

Manabu HORI ◽

Ikuo WATANABE ◽

Hisayoshi TSUTSUI ◽

Kengo HARADA ◽

...

Keyword(s):

Quantitative Structure Activity Relationship ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Quantitative Structure ◽

Design Synthesis ◽

Guanidine Derivatives ◽

Structure Activity ◽

Relationship Study

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Design, Synthesis, Biological Screening and Structure Activity Relationship Study of 4, 6-Dimethyl-2-(Substituted) Mercapto-3-(Substituted) Pyridines as Anti Tubercular Agents

American Journal of Infectious Diseases ◽

10.3844/ajidsp.2011.61.66 ◽

2011 ◽

Vol 7 (3) ◽

pp. 61-66 ◽

Cited By ~ 1

Author(s):

Rozita

Keyword(s):

Structure Activity Relationship ◽

Activity Relationship ◽

Biological Screening ◽

Design Synthesis ◽

Structure Activity ◽

Substituted Pyridines ◽

Relationship Study

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Design, synthesis and structure-activity relationship study of novel urea compounds as FGFR1 inhibitors to treat metastatic triple-negative breast cancer

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2020.112866 ◽

2021 ◽

Vol 209 ◽

pp. 112866

Author(s):

Md Ashraf-Uz-Zaman ◽

Sadisna Shahi ◽

Racheal Akwii ◽

Md Sanaullah Sajib ◽

Mohammad Jodeiri Farshbaf ◽

...

Keyword(s):

Breast Cancer ◽

Triple Negative Breast Cancer ◽

Triple Negative ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Design Synthesis ◽

Structure Activity ◽

Relationship Study ◽

Urea Compounds

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Design, Synthesis, and Structure–Activity Relationship Exploration of Alkyl/Phenylalkyl Piperidine Analogues as Novel Highly Potent and Selective μ Opioid Receptor Agonists

ACS Chemical Neuroscience ◽

10.1021/acschemneuro.0c00487 ◽

2020 ◽

Author(s):

Huoming Huang ◽

Xinwei Li ◽

Wei Guo ◽

Chen Zhu ◽

Yuanyuan Qian ◽

...

Keyword(s):

Opioid Receptor ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Design Synthesis ◽

Receptor Agonists ◽

Structure Activity ◽

Μ Opioid Receptor ◽

Opioid Receptor Agonists

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ChemInform Abstract: Design, Synthesis and Quantitative Structure-Activity Relationship Study of N-(3-Oxo-3,4-dihydro-2H-benzo[1,4]oxazine-7-carbonyl)guanidine Derivatives as Potent Na/H Exchange Inhibitors.

ChemInform ◽

10.1002/chin.199823160 ◽

2010 ◽

Vol 29 (23) ◽

pp. no-no

Author(s):

T. YAMAMOTO ◽

M. HORI ◽

I. WATANABE ◽

H. TSUTSUI ◽

K. HARADA ◽

...

Keyword(s):

Quantitative Structure Activity Relationship ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Quantitative Structure ◽

Design Synthesis ◽

Guanidine Derivatives ◽

Structure Activity ◽

Relationship Study

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Design, Synthesis and Structure-Activity Relationship Study of Coumarin Benzimidazole Hybrid as Potent Antibacterial and Anticancer Agents

ChemistrySelect ◽

10.1002/slct.201600665 ◽

2016 ◽

Vol 1 (15) ◽

pp. 4638-4644 ◽

Cited By ~ 13

Author(s):

Megharaja Holiyachi ◽

Samundeeswari L. Shastri ◽

Bahubali M. Chougala ◽

Lokesh A. Shastri ◽

Shrinivas D. Joshi ◽

...

Keyword(s):

Anticancer Agents ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Design Synthesis ◽

Structure Activity ◽

Relationship Study

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Design, Synthesis, and Quantitative Structure−Activity Relationship Study of Herbicidal Analogues of Pyrazolo[5,1-d][1,2,3,5]tetrazin-4(3H)ones

Journal of Agricultural and Food Chemistry ◽

10.1021/jf063271n ◽

2007 ◽

Vol 55 (4) ◽

pp. 1364-1369 ◽

Cited By ~ 14

Author(s):

You-quan Zhu ◽

Chao Wu ◽

Hua-bin Li ◽

Xiao-mao Zou ◽

Xue-kai Si ◽

...

Keyword(s):

Quantitative Structure Activity Relationship ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Quantitative Structure ◽

Design Synthesis ◽

Structure Activity ◽

Relationship Study

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Design, synthesis, and structure-activity relationship study of glycyrrhetinic acid derivatives as potent and selective inhibitors against human carboxylesterase 2

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2016.02.020 ◽

2016 ◽

Vol 112 ◽

pp. 280-288 ◽

Cited By ~ 47

Author(s):

Li-Wei Zou ◽

Yao-Guang Li ◽

Ping Wang ◽

Kun Zhou ◽

Jie Hou ◽

...

Keyword(s):

Structure Activity Relationship ◽

Glycyrrhetinic Acid ◽

Activity Relationship ◽

Selective Inhibitors ◽

Design Synthesis ◽

Structure Activity ◽

Relationship Study

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