The calcium-sensing receptor regulates PTHrP production and calcium transport in the lactating mammary gland

Bone ◽  
2006 ◽  
Vol 38 (6) ◽  
pp. 787-793 ◽  
Author(s):  
Laleh Ardeshirpour ◽  
Pamela Dann ◽  
Martin Pollak ◽  
John Wysolmerski ◽  
Joshua VanHouten
Keyword(s):  
Mammary Gland ◽  
Calcium Transport ◽  
Calcium Sensing Receptor ◽  
Calcium Sensing ◽  
Lactating Mammary Gland

scholarly journals Mammary-Specific Ablation of the Calcium-Sensing Receptor During Lactation Alters Maternal Calcium Metabolism, Milk Calcium Transport, and Neonatal Calcium Accrual

Endocrinology ◽  
2013 ◽  
Vol 154 (9) ◽  
pp. 3031-3042 ◽  
Author(s):  
Ramanaiah Mamillapalli ◽  
Joshua VanHouten ◽  
Pamela Dann ◽  
Daniel Bikle ◽  
Wenhan Chang ◽  
...  
Keyword(s):  
Calcium Transport ◽  
Calcium Metabolism ◽  
Calcium Sensing Receptor ◽  
Calcium Sensing

The calcium-sensing receptor regulates calcium absorption in MDCK cells by inhibition of PMCA

2001 ◽  
Vol 280 (5) ◽  
pp. F815-F822 ◽  
Author(s):  
Kristy A. Blankenship ◽  
J. Jason Williams ◽  
Martha S. Lawrence ◽  
Kenneth R. McLeish ◽  
William L. Dean ◽  
...  
Keyword(s):  
Calcium Transport ◽  
Calcium Absorption ◽  
Mdck Cells ◽  
Distal Tubule ◽  
Dependent Manner ◽  
Potential Mechanism ◽  
Calcium Sensing Receptor ◽  
Basal Surface ◽  
Calcium Sensing ◽  
Stimulation Of

Calcium transport across a monolayer of Madin-Darby canine kidney (MDCK) cells was measured in response to stimulation of the basal surface with calcium-sensing receptor (CaR) agonists. Stimulation of the CaR resulted in a time- and concentration-dependent inhibition of calcium transport but did not change transepithelial voltage or resistance. Inhibition of transport was not altered by pretreatment of cells with pertussis toxin but was blocked by the phospholipase C (PLC) inhibitor U-73122. To determine a potential mechanism by which the CaR could inhibit calcium transport, we measured activity of the plasma membrane calcium ATPase (PMCA). Stimulation of the CaR on the basal surface resulted in an inhibition of the PMCA in a concentration- and PLC-dependent manner. Thus stimulation of the CaR inhibits both calcium transport and PMCA activity through a PLC-dependent pathway. These studies provide the first direct evidence that calcium can inhibit its own transcellular absorption in a model of the distal tubule. In addition, they provide a potential mechanism for the CaR to inhibit calcium transport, inhibition of PMCA.

scholarly journals Ways of calcium reabsorption in the kidney

2016 ◽  
Vol 310 (11) ◽  
pp. F1337-F1350 ◽  
Author(s):  
Matthias B. Moor ◽  
Olivier Bonny
Keyword(s):  
Calcium Homeostasis ◽  
Calcium Transport ◽  
Feedback System ◽  
Calcium Handling ◽  
Sodium Reabsorption ◽  
Calcium Sensing Receptor ◽  
Calcium Sensing ◽  
Calcitropic Hormones ◽  
Calcium Reabsorption

The role of the kidney in calcium homeostasis has been reshaped from a classic view in which the kidney was regulated by systemic calcitropic hormones such as vitamin D3 or parathyroid hormone to an organ actively taking part in the regulation of calcium handling. With the identification of the intrinsic renal calcium-sensing receptor feedback system, the regulation of paracellular calcium transport involving claudins, and new paracrine regulators such as klotho, the kidney has emerged as a crucial modulator not only of calciuria but also of calcium homeostasis. This review summarizes recent molecular and endocrine contributors to renal calcium handling and highlights the tight link between calcium and sodium reabsorption in the kidney.

Abstract #543 Teriparatide-Induced Hypercalcemic Crisis in a Patient on Lithium: Overwhelming the Calcium Sensing Receptor

2018 ◽  
Vol 24 ◽  
pp. 130-131
Author(s):  
Pratibha Abraham ◽  
Muhammad Siddiqui ◽  
Deepashree Gupta ◽  
Stewart Albert
Keyword(s):  
Calcium Sensing Receptor ◽  
Hypercalcemic Crisis ◽  
Calcium Sensing
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