scholarly journals The Role of “Raft-Like” Membranes on Antimicrobial Peptide-Lipid Bilayer Interactions

2012 ◽  
Vol 102 (3) ◽  
pp. 495a
Author(s):  
Austin J. McHenry ◽  
Michele F.M. Sciacca ◽  
Jeffrey R. Brender ◽  
Kevin Hartman ◽  
Ayyalusamy Ramamoorthy
Keyword(s):  
Antimicrobial Peptide ◽  
Lipid Bilayer

scholarly journals Towards designing globular antimicrobial peptide mimics: role of polar functional groups in biomimetic ternary antimicrobial polymers

Soft Matter ◽  
2021 ◽  
Author(s):  
Garima Rani ◽  
Kenichi Kuroda ◽  
Satyavani Vemparala
Keyword(s):  
Molecular Dynamics ◽  
Antimicrobial Peptide ◽  
Bacterial Membrane ◽  
Simulation Data ◽  
Antimicrobial Polymers ◽  
Polar Groups ◽  
Methacrylate Polymers ◽  
Dynamics Simulations ◽  
Polar Functional Groups

Using atomistic molecular dynamics simulations, we study the interaction of ternary methacrylate polymers, composed of charged cationic, hydrophobic and neutral polar groups, with model bacterial membrane. Our simulation data shows...

Role of nuclear hormone receptors in butyrate-mediated up-regulation of the antimicrobial peptide cathelicidin in epithelial colorectal cells

2007 ◽  
Vol 44 (8) ◽  
pp. 2107-2114 ◽  
Author(s):  
Markus Schwab ◽  
Veerle Reynders ◽  
Yogesh Shastri ◽  
Stefan Loitsch ◽  
Jürgen Stein ◽  
...  
Keyword(s):  
Antimicrobial Peptide ◽  
Hormone Receptors ◽  
Nuclear Hormone Receptors

Extracellular vesicle interplay in cardiovascular pathophysiology

2021 ◽  
Author(s):  
Sherin Saheera ◽  
Vivek P Jani ◽  
Kenneth W Witwer ◽  
Shelby Kutty
Keyword(s):  
Plasma Membrane ◽  
Cardiovascular System ◽  
Lipid Bilayer ◽  
Cellular Responses ◽  
Extracellular Vesicle ◽  
Cargo Proteins ◽  
And Function ◽  
Intercellular Communications ◽  
Rna And Dna

Extracellular vesicles (EVs) are nanosized lipid bilayer-delimited particles released from cells that mediate intercellular communications and play a pivotal role in various physiological and pathological processes. Subtypes of EVs may include plasma-membrane ectosomes or microvesicles and endosomal-origin exosomes, although functional distinctions remain unclear. EVs carry cargo proteins, nucleic acids (RNA and DNA), lipids, and metabolites. By presenting or transferring this cargo to recipient cells, EVs can trigger cellular responses. Here, we summarize what is known about EV biogenesis, composition, and function, with an emphasis on the role of EVs in cardiovascular system. Additionally, we provide an update on the function of EVs in cardiovascular pathophysiology, further highlighting their potential for diagnostic and therapeutic applications.

scholarly journals Potential role of an antimicrobial peptide, KLK in inhibiting lipopolysaccharide-induced macrophage inflammation

PLoS ONE ◽  
2017 ◽  
Vol 12 (8) ◽  
pp. e0183852 ◽  
Author(s):  
Pornpimon Jantaruk ◽  
Sittiruk Roytrakul ◽  
Sutthirat Sitthisak ◽  
Duangkamol Kunthalert
Keyword(s):  
Antimicrobial Peptide ◽  
Potential Role

scholarly journals Orientation and Dynamics of an Antimicrobial Peptide in the Lipid Bilayer by Solid-State NMR Spectroscopy

2001 ◽  
Vol 81 (4) ◽  
pp. 2203-2214 ◽  
Author(s):  
Satoru Yamaguchi ◽  
Daniel Huster ◽  
Alan Waring ◽  
Robert I. Lehrer ◽  
William Kearney ◽  
...  
Keyword(s):  
Solid State ◽  
Nmr Spectroscopy ◽  
Antimicrobial Peptide ◽  
Lipid Bilayer ◽  
Solid State Nmr ◽  
Solid State Nmr Spectroscopy

scholarly journals Borrelia burgdorferi Resistance to a Major Skin Antimicrobial Peptide Is Independent of Outer Surface Lipoprotein Content

2009 ◽  
Vol 53 (10) ◽  
pp. 4490-4494 ◽  
Author(s):  
Amit Sarkar ◽  
Kit Tilly ◽  
Philip Stewart ◽  
Aaron Bestor ◽  
James M. Battisti ◽  
...  
Keyword(s):  
Borrelia Burgdorferi ◽  
Antimicrobial Peptide ◽  
Immune Evasion ◽  
Essential Role ◽  
Potential Role ◽  
Innate Immune ◽  
Initial Stage ◽  
Mammalian Infection ◽  
Innate Immune Evasion

ABSTRACT We hypothesize a potential role for Borrelia burgdorferi OspC in innate immune evasion at the initial stage of mammalian infection. We demonstrate that B. burgdorferi is resistant to high levels (>200 μg/ml) of cathelicidin and that this antimicrobial peptide exhibits limited binding to the spirochetal outer membrane, irrespective of OspC or other abundant surface lipoproteins. We conclude that the essential role of OspC is unrelated to resistance to this component of innate immunity.

Sign in / Sign up

Export Citation Format

Share Document