scholarly journals Ion Permeation Efficiency through Potassium Channels

2014 ◽  
Vol 106 (2) ◽  
pp. 539a
Author(s):  
David A. Kopfer ◽  
Chen Song ◽  
Ulrich Zachariae ◽  
Bert L. de Groot
Keyword(s):  
Potassium Channels ◽  
Ion Permeation

scholarly journals The Link between Ion Permeation and Inactivation Gating of Kv4 Potassium Channels

2003 ◽  
Vol 84 (2) ◽  
pp. 928-941 ◽  
Author(s):  
Mohammad Shahidullah ◽  
Manuel Covarrubias
Keyword(s):  
Potassium Channels ◽  
Ion Permeation ◽  
Inactivation Gating

scholarly journals Regulation of ion Permeation in the Selectivity Filter of Potassium Channels

2014 ◽  
Vol 106 (2) ◽  
pp. 234a
Author(s):  
Simon Berneche ◽  
Wojciech Wojtas-Niziurski ◽  
Florian Heer
Keyword(s):  
Potassium Channels ◽  
Selectivity Filter ◽  
Ion Permeation

scholarly journals Targeting potassium channels in cancer

2014 ◽  
Vol 206 (2) ◽  
pp. 151-162 ◽  
Author(s):  
Xi Huang ◽  
Lily Yeh Jan
Keyword(s):  
Potassium Channels ◽  
Potassium Channel ◽  
Cancer Therapeutics ◽  
Ion Permeation ◽  
Cell Behaviors ◽  
Independent Functions ◽  
Channel Expression ◽  
Surface Localization ◽  
Cell Surface Localization ◽  
And Migration

Potassium channels are pore-forming transmembrane proteins that regulate a multitude of biological processes by controlling potassium flow across cell membranes. Aberrant potassium channel functions contribute to diseases such as epilepsy, cardiac arrhythmia, and neuromuscular symptoms collectively known as channelopathies. Increasing evidence suggests that cancer constitutes another category of channelopathies associated with dysregulated channel expression. Indeed, potassium channel–modulating agents have demonstrated antitumor efficacy. Potassium channels regulate cancer cell behaviors such as proliferation and migration through both canonical ion permeation–dependent and noncanonical ion permeation–independent functions. Given their cell surface localization and well-known pharmacology, pharmacological strategies to target potassium channel could prove to be promising cancer therapeutics.

scholarly journals Molecular Simulations of Ion Permeation in Potassium Channels

2017 ◽  
Vol 112 (3) ◽  
pp. 163a
Author(s):  
Wojciech Kopec ◽  
Bert de Groot
Keyword(s):  
Potassium Channels ◽  
Molecular Simulations ◽  
Ion Permeation

scholarly journals Ion Permeation in Potassium Channels Involves Direct Coulomb Knock-On between Ions

2015 ◽  
Vol 108 (2) ◽  
pp. 118a
Author(s):  
Ulrich Zachariae ◽  
David A. Kopfer ◽  
Chen Song ◽  
Tim Gruene ◽  
George M. Sheldrick ◽  
...  
Keyword(s):  
Potassium Channels ◽  
Ion Permeation
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