NLX-112, a highly selective 5-HT 1A receptor agonist, mediates analgesia and antidepressant-like activity in rats via spinal cord and prefrontal cortex 5-HT 1A receptors, respectively

2018 ◽  
Vol 1688 ◽  
pp. 1-7 ◽  
Author(s):  
A. Newman-Tancredi ◽  
L. Bardin ◽  
A. Auclair ◽  
F. Colpaert ◽  
R. Depoortère ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Prefrontal Cortex ◽  
Receptor Agonist

Rapid anxiolytic effects of 5-HT4 receptor agonist involves prefrontal cortex-brainstem neural circuit recruitment

2019 ◽  
Vol 29 ◽  
pp. S204-S205 ◽  
Author(s):  
C. Faye ◽  
R. Hen ◽  
B.P. Guiard ◽  
C.A. Denny ◽  
A.M. Gardier ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Receptor Agonist ◽  
Neural Circuit

The very-high-efficacy 5-HT1A receptor agonist, F 13640, preempts the development of allodynia-like behaviors in rats with spinal cord injury

2003 ◽  
Vol 478 (2-3) ◽  
pp. 131-137 ◽  
Author(s):  
Wei-Ping Wu ◽  
Jing-Xia Hao ◽  
Xiao-Jun Xu ◽  
Zsuzsanna Wiesenfeld-Hallin ◽  
Wouter Koek ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Receptor Agonist ◽  
High Efficacy ◽  
Cord Injury ◽  
Very High

Investigation of the effectiveness of a ghrelin receptor agonist to stimulate the defecation centre in spinal cord injured rats

2011 ◽  
Vol 163 (1-2) ◽  
pp. 58
Author(s):  
J.B. Furness ◽  
D.M. Ferens ◽  
M.D. Habgood ◽  
N.R. Saunders ◽  
D.J. Brown ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Receptor Agonist ◽  
Ghrelin Receptor ◽  
Ghrelin Receptor Agonist ◽  
Spinal Cord Injured

The α7 nicotinic receptor agonist SSR180711 increases activity regulated cytoskeleton protein (Arc) gene expression in the prefrontal cortex of the rat

2007 ◽  
Vol 418 (2) ◽  
pp. 154-158 ◽  
Author(s):  
Søren E. Kristensen ◽  
Morten S. Thomsen ◽  
Henrik H. Hansen ◽  
Daniel B. Timmermann ◽  
Anders Hay-Schmidt ◽  
...  
Keyword(s):  
Gene Expression ◽  
Prefrontal Cortex ◽  
Nicotinic Receptor ◽  
Receptor Agonist ◽  
Cytoskeleton Protein ◽  
Arc Gene

scholarly journals Analgesic and Antidepressant Effects of Oltipraz on Neuropathic Pain in Mice by Modulating Microglial Activation

2019 ◽  
Vol 8 (6) ◽  
pp. 890 ◽  
Author(s):  
Andrés Felipe Díaz ◽  
Sara Polo ◽  
Núria Gallardo ◽  
Sergi Leánez ◽  
Olga Pol
Keyword(s):  
Spinal Cord ◽  
Neuropathic Pain ◽  
Prefrontal Cortex ◽  
Emotional Disorders ◽  
Microglial Activation ◽  
Antioxidant Properties ◽  
Heme Oxygenase 1 ◽  
Related Factor ◽  
Nuclear Factor ◽  
Antidepressant Effects

Nerve injury provokes microglial activation, contributing to the sensory and emotional disorders associated with neuropathic pain that do not completely resolve with treatment. In C57BL/6J mice with neuropathic pain induced by chronic constriction of the sciatic nerve (CCI), we evaluated the effects of oltipraz, an antioxidant and anticancer compound, on (1) allodynia and hyperalgesia, (2) microglial activation and pain signaling pathways, (3) oxidative stress, and (4) depressive-like behaviors. Twenty-eight days after surgery, we assessed the effects of oltipraz on the expression of CD11b/c (a microglial marker), phosphoinositide 3-kinase (PI3K)/ phosphorylated protein kinase B (p-Akt), nuclear factor-κB (NF-κB) transcription factor, and mitogen activated protein kinases (MAPK) in the spinal cord, hippocampus, and prefrontal cortex. Our results show that oltipraz alleviates neuropathic pain by inhibiting microglial activation and PI3K/p-Akt, phosphorylated inhibitor of κBα (p-IκBα), and MAPK overexpression, and by normalizing and/or enhancing the expression of antioxidant proteins, nuclear factor erythroid derived-2-related factor 2 (Nrf2), heme oxygenase 1 (HO-1), and NAD(P)H:quinone oxidoreductase-1 (NQO1) in the spinal cord. The inhibition of microglial activation and induction of the Nrf2/HO-1/NQO1 signaling pathway in the hippocampus and/or prefrontal cortex may explain the antidepressant effects of oltipraz during neuropathic pain. These data demonstrate the analgesic and antidepressant effects of oltipraz and reveal its protective and antioxidant properties during chronic pain.

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