Melatonin exerts its analgesic actions not by binding to opioid receptor subtypes but by increasing the release of β-endorphin an endogenous opioid

2005 ◽  
Vol 64 (6) ◽  
pp. 471-479 ◽  
Author(s):  
Shaik Shavali ◽  
Begonia Ho ◽  
Piyarat Govitrapong ◽  
Saiphon Sawlom ◽  
Amornpan Ajjimaporn ◽  
...  
Keyword(s):  
Opioid Receptor ◽  
Receptor Subtypes ◽  
Endogenous Opioid ◽  
Opioid Receptor Subtypes

Interleukin-6 is differently modulated by central opioid receptor subtypes

1997 ◽  
Vol 273 (3) ◽  
pp. R956-R959 ◽  
Author(s):  
M. Bertolucci ◽  
C. Perego ◽  
M. G. De Simoni
Keyword(s):  
Opioid Receptor ◽  
Fine Tuning ◽  
Opioid System ◽  
Receptor Subtypes ◽  
Receptor Blockade ◽  
Endogenous Opioid System ◽  
Endogenous Opioid ◽  
General Role ◽  
Opioid Receptor Subtypes ◽  
Mu Antagonist

The central endogenous opioid system is involved in the modulation of interleukin (IL)-6, an inflammatory cytokine that plays a major role in the acute phase response. The present study evaluates whether specific opioid receptor subtypes are selectively involved in this immunomodulatory action. IL-1 beta was administered either intracerebroventricularly or intraperitoneally at the dose of 400 ng to rats pretreated with the mu-antagonist beta-funaltrexamine, the delta-antagonist naltrindole, or the kappa-antagonist nor-binaltorphimine, each at the doses of 1, 10, and 100 micrograms/rat intracerebroventricularly. Serum IL-6 levels were measured 2 h later. The results show that mu-receptor blockade increases, whereas delta-receptor blockade decreases IL-6 induction, suggesting that the fine tuning exerted by opioids on the immune system may be achieved through a balance of opposing effects. Moreover the three antagonists affect IL-6 induction by central and peripheral IL-1 beta with a similar pattern, indicating that the brain endogenous opioid system plays a general role in the regulation of this cytokine.

Roles of opioid receptor subtypes in rats' feeding behavior

Appetite ◽  
1991 ◽  
Vol 17 (3) ◽  
pp. 239 ◽  
Author(s):  
Richard J. Bodnar ◽  
Nori Geary
Keyword(s):  
Feeding Behavior ◽  
Opioid Receptor ◽  
Receptor Subtypes ◽  
Opioid Receptor Subtypes

The Delta Opioid Receptor Subtypes and Pain Modulation

2003 ◽  
Author(s):  
Michael Ossipov ◽  
Josephine Lai ◽  
Todd Vanderah ◽  
Frank Porreca
Keyword(s):  
Opioid Receptor ◽  
Pain Modulation ◽  
Delta Opioid Receptor ◽  
Receptor Subtypes ◽  
Opioid Receptor Subtypes

scholarly journals Roles of opioid receptor subtypes in mediating alcohol-seeking induced by discrete cues and context

2009 ◽  
Vol 30 (4) ◽  
pp. 671-678 ◽  
Author(s):  
Peter W. Marinelli ◽  
Douglas Funk ◽  
Stephen Harding ◽  
Zhaoxia Li ◽  
Walter Juzytsch ◽  
...  
Keyword(s):  
Opioid Receptor ◽  
Receptor Subtypes ◽  
Opioid Receptor Subtypes ◽  
Alcohol Seeking
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