The genome of the minute marine rotifer Proales similis: Genome-wide identification of 401 G protein-coupled receptor (GPCR) genes

2021 ◽  
pp. 100861
Author(s):  
Duck-Hyun Kim ◽  
Min-Sub Kim ◽  
Atsushi Hagiwara ◽  
Jae-Seong Lee
Keyword(s):  
G Protein ◽  
G Protein Coupled Receptor ◽  
Genome Wide ◽  
G Protein Coupled ◽  
Marine Rotifer

scholarly journals Genome-Wide RNA Interference in Drosophila Cells Identifies G Protein-Coupled Receptor Kinase 2 as a Conserved Regulator of NF-κB Signaling

2010 ◽  
Vol 184 (11) ◽  
pp. 6188-6198 ◽  
Author(s):  
Susanna Valanne ◽  
Henna Myllymäki ◽  
Jenni Kallio ◽  
Martin Rudolf Schmid ◽  
Anni Kleino ◽  
...  
Keyword(s):  
Rna Interference ◽  
G Protein ◽  
Receptor Kinase ◽  
G Protein Coupled Receptor ◽  
Genome Wide ◽  
G Protein Coupled ◽  
Drosophila Cells

scholarly journals The G protein–coupled receptor GPR31 promotes membrane association of KRAS

2017 ◽  
Vol 216 (8) ◽  
pp. 2329-2338 ◽  
Author(s):  
Nicole Fehrenbacher ◽  
Israel Tojal da Silva ◽  
Craig Ramirez ◽  
Yong Zhou ◽  
Kwang-Jin Cho ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Plasma Membrane ◽  
Tumor Cells ◽  
G Protein ◽  
Secretory Pathway ◽  
Membrane Association ◽  
G Protein Coupled Receptor ◽  
Genome Wide ◽  
A Genome ◽  
G Protein Coupled

The product of the KRAS oncogene, KRAS4B, promotes tumor growth when associated with the plasma membrane (PM). PM association is mediated, in part, by farnesylation of KRAS4B, but trafficking of nascent KRAS4B to the PM is incompletely understood. We performed a genome-wide screen to identify genes required for KRAS4B membrane association and identified a G protein–coupled receptor, GPR31. GPR31 associated with KRAS4B on cellular membranes in a farnesylation-dependent fashion, and retention of GPR31 on the endoplasmic reticulum inhibited delivery of KRAS4B to the PM. Silencing of GPR31 expression partially mislocalized KRAS4B, slowed the growth of KRAS-dependent tumor cells, and blocked KRAS-stimulated macropinocytosis. Our data suggest that GPR31 acts as a secretory pathway chaperone for KRAS4B.

Vanadium compounds cause activation of G protein-coupled receptor signaling

2020 ◽  
Author(s):  
Debbie C. Crans ◽  
Duaa Althumairy ◽  
Heide Murakami ◽  
B. George Barisas ◽  
Deborah Roess
Keyword(s):  
G Protein ◽  
Receptor Signaling ◽  
G Protein Coupled Receptor ◽  
Vanadium Compounds ◽  
G Protein Coupled
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