scholarly journals Gastroprotective effect of the alkaloid boldine: Involvement of non-protein sulfhydryl groups, prostanoids and reduction on oxidative stress

2020 ◽  
Vol 327 ◽  
pp. 109166
Author(s):  
Thaise Boeing ◽  
Luisa Natália Bolda Mariano ◽  
Ana Caroline dos Santos ◽  
Bianca Tolentino ◽  
Angela Cadorin Vargas ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Sulfhydryl Groups ◽  
Gastroprotective Effect ◽  
Protein Sulfhydryl ◽  
Protein Sulfhydryl Groups

Lipopolysaccharide from Escherichia coli prevents indomethacin-induced gastric damage in rats: role of non-protein sulfhydryl groups and leukocyte adherence

2009 ◽  
Vol 58 (10) ◽  
pp. 717-723 ◽  
Author(s):  
Antoniella Souza Gomes ◽  
Henrique Paula Lemos ◽  
Jand Venes Rolim Medeiros ◽  
Fernando Queiroz Cunha ◽  
Marcellus Henrique Loiola Ponte Souza
Keyword(s):  
Escherichia Coli ◽  
Sulfhydryl Groups ◽  
Gastric Damage ◽  
Leukocyte Adherence ◽  
Protein Sulfhydryl ◽  
Protein Sulfhydryl Groups

Amifostine (Wr-2721) Prevents Indomethacin-Induced Gastric Damage in Rats: Role of Non-Protein Sulfhydryl Groups and Leukocyte Adherence

2006 ◽  
Vol 52 (1) ◽  
pp. 119-125 ◽  
Author(s):  
José Maurício S. C. Mota ◽  
Pedro M. G. Soares ◽  
Álvaro A. J. Menezes ◽  
Henrique P. Lemos ◽  
Fernando Q. Cunha ◽  
...  
Keyword(s):  
Sulfhydryl Groups ◽  
Gastric Damage ◽  
Leukocyte Adherence ◽  
Protein Sulfhydryl ◽  
Protein Sulfhydryl Groups

Accessibility of protein sulfhydryl groups to nitroxyl spin labels

1997 ◽  
Vol 408-409 ◽  
pp. 177-180 ◽  
Author(s):  
Marianna Török ◽  
Kálmán Hideg ◽  
László Dux ◽  
LászlóI. Horváth
Keyword(s):  
Sulfhydryl Groups ◽  
Spin Labels ◽  
Protein Sulfhydryl ◽  
Protein Sulfhydryl Groups

Estimation of protein sulfhydryl groups with 5,5′-[35S] dithio-bis(2-nitrobenzoate)

1974 ◽  
Vol 59 (2) ◽  
pp. 416-425 ◽  
Author(s):  
Peter M. Steinert ◽  
B.Suren Baliga ◽  
Hamish N. Munro
Keyword(s):  
Sulfhydryl Groups ◽  
Protein Sulfhydryl ◽  
Protein Sulfhydryl Groups

scholarly journals Protein Sulfhydryl Group Oxidation and Mixed-Disulfide Modifications in Stable and Unstable Human Carotid Plaques

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
Antonio Junior Lepedda ◽  
Angelo Zinellu ◽  
Gabriele Nieddu ◽  
Elisabetta Zinellu ◽  
Ciriaco Carru ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Protein Function ◽  
Sulfhydryl Group ◽  
Plaque Stability ◽  
Proteomic Approach ◽  
Oxidative Modifications ◽  
Protein Sulfhydryl ◽  
Unstable Plaques ◽  
Protein Sulfhydryl Groups ◽  
Human Carotid

Objectives. Oxidative stress has been implicated in the outcome of atherosclerotic plaques. However, at present, no data are available neither on the degree of plaque protein sulfhydryl groups oxidation nor on its relationship with plaque vulnerability. We investigated the entity of protein-SH oxidative modifications, focusing on low molecular weight thiols adduction, in human carotid plaque extracts in relation to plaque stability/instability.Methods. Plaque stability/instability was histologically assessed. The extent of protein-SH oxidative modifications was established by a differential proteomic approach on fluorescein-5-maleimide-labeled plaque extracts and corresponding plasma samples from 48 endarterectomized patients. The analysis on protein thiolation was performed by capillary zone electrophoresis.Results. We observed a higher protein-SH oxidation of both plasma-derived and topically expressed proteins in unstable plaques, partly due to higher levels of S-thiolation. Conversely, in plasma, none of the investigated parameters discriminated among patients with stable and unstable plaques.Conclusions. Our results suggest the presence of a more pronounced oxidative environment in unstable plaques. Identifying specific oxidative modifications and understanding their effects on protein function could provide further insight into the relevance of oxidative stress in atherosclerosis.

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