Recent advances in 1,8-naphthalimide-based small-molecule fluorescent probes for organelles imaging and tracking in living cells

Here we report a small molecule probe for single molecule localisation microscopy (SMLM) of tubulin in living and fixed cells. We explored a series of constructs composed of taxanes and spontaneously blinking far-red dye hydroxymethyl silicon-rhodamine (HMSiR). We found that the linker length profoundly affects the probe permeability and off-targeting. The best performing probe, HMSiR-tubulin, is composed of cabazitaxel and 6'-regioisomer of HMSiR bridged by a C6 linker. Microtubule diameters of <50 nm can be routinely measured in SMLM experiments on living and fixed cells. HMSiR-tubulin also performs well in 3D stimulated emission depletion (STED) microscopy, allowing a complementary use of both nanoscopy methods for investigating microtubule functions in living cells.

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Recent progresses in small-molecule enzymatic fluorescent probes for cancer imaging

Chemical Society Reviews ◽

10.1039/c7cs00862g ◽

2018 ◽

Vol 47 (18) ◽

pp. 7140-7180 ◽

Cited By ~ 261

Author(s):

Hong-Wen Liu ◽

Lanlan Chen ◽

Chengyan Xu ◽

Zhe Li ◽

Haiyang Zhang ◽

...

Keyword(s):

Small Molecule ◽

Fluorescent Probes ◽

Cancer Imaging ◽

Design Strategies ◽

Recent Advances

An overview of recent advances in small-molecule enzymatic fluorescent probes for cancer imaging, including design strategies and cancer imaging applications.

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Recent advances in mitochondria- and lysosomes-targeted small-molecule two-photon fluorescent probes

Chinese Chemical Letters ◽

10.1016/j.cclet.2017.09.026 ◽

2017 ◽

Vol 28 (10) ◽

pp. 1943-1951 ◽

Cited By ~ 45

Author(s):

Peng Ning ◽

Wenjuan Wang ◽

Man Chen ◽

Yan Feng ◽

Xiangming Meng

Keyword(s):

Small Molecule ◽

Fluorescent Probes ◽

Two Photon ◽

Recent Advances

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Recent advances in 4-hydroxy-1,8-naphthalimide-based small-molecule fluorescent probes

Coordination Chemistry Reviews ◽

10.1016/j.ccr.2021.214153 ◽

2021 ◽

Vol 448 ◽

pp. 214153

Author(s):

Hanchuang Zhu ◽

Caiyun Liu ◽

Meijun Su ◽

Xiaodi Rong ◽

Yan Zhang ◽

...

Keyword(s):

Small Molecule ◽

Fluorescent Probes ◽

Recent Advances

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Small-molecule Bifunctional Fluorescent Probes for the Differential Detection of Multiple Guests

Current Organic Synthesis ◽

10.2174/1570179416666190419213812 ◽

2019 ◽

Vol 16 (4) ◽

pp. 485-497 ◽

Cited By ~ 1

Author(s):

Pei-Pei Jia ◽

Shu-Ting Jiang ◽

Lin Xu

Keyword(s):

Real Time ◽

Small Molecule ◽

Fluorescent Probes ◽

Design Principles ◽

Differential Detection ◽

Recent Advances ◽

Multiple Analytes ◽

Real Time Applications

During the last few years, the preparation of bifunctional fluorescent probes, which exhibit dierential response towards multiple analytes, has attracted considerable attention since they are cost-eective and highly desirable for real-time applications. This review focuses on the recent advances in the design principles, recognition mechanisms,and applications of multifunctional fluorescent probes for the differential detection of multiple guests.

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Förster resonance energy transfer (FRET)-based small-molecule sensors and imaging agents

Chemical Society Reviews ◽

10.1039/c9cs00318e ◽

2020 ◽

Vol 49 (15) ◽

pp. 5110-5139 ◽

Cited By ~ 12

Author(s):

Luling Wu ◽

Chusen Huang ◽

Ben P. Emery ◽

Adam C. Sedgwick ◽

Steven D. Bull ◽

...

Keyword(s):

Energy Transfer ◽

Small Molecule ◽

Fluorescent Probes ◽

Resonance Energy Transfer ◽

Resonance Energy ◽

Forster Resonance Energy Transfer ◽

Förster Resonance Energy Transfer ◽

Imaging Agents ◽

Recent Advances ◽

Förster Resonance

In this tutorial review, we will explore recent advances in the construction and application of Förster resonance energy transfer (FRET)-based small-molecule fluorescent probes.

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