scholarly journals Cell–cell contact and signaling in the muscle stem cell niche

2021 ◽  
Vol 73 ◽  
pp. 78-83
Author(s):  
Allison P. Kann ◽  
Margaret Hung ◽  
Robert S. Krauss
Author(s):  
Omid Mashinchian ◽  
Addolorata Pisconti ◽  
Emmeran Le Moal ◽  
C. Florian Bentzinger

2017 ◽  
Vol 145 ◽  
pp. S173
Author(s):  
Meryem Baghdadi ◽  
David Castel ◽  
So-ichiro Fukada ◽  
David Birk ◽  
Frederic Relaix ◽  
...  

2011 ◽  
Vol 15 (10) ◽  
pp. 2269-2272 ◽  
Author(s):  
Florina M. Bojin ◽  
Oana I. Gavriliuc ◽  
Mirabela I. Cristea ◽  
Gabriela Tanasie ◽  
Carmen S. Tatu ◽  
...  

2021 ◽  
Vol 1 (10) ◽  
Author(s):  
Svenja C. Schüler ◽  
Simon Dumontier ◽  
Jonathan Rigaux ◽  
C. Florian Bentzinger

Aging Cell ◽  
2008 ◽  
Vol 7 (4) ◽  
pp. 590-598 ◽  
Author(s):  
Suchitra D. Gopinath ◽  
Thomas A. Rando

2020 ◽  
Author(s):  
Dhanushika Ratnayake ◽  
Phong D. Nguyen ◽  
Fernando J. Rossello ◽  
Verena C. Wimmer ◽  
Abdulsalam I. Isiaku ◽  
...  

AbstractSkeletal muscle is paradigmatic of a regenerative tissue that repairs itself via the activation of a resident stem cell1. Termed the satellite cell, these normally quiescent cells are induced to proliferate by ill-defined wound-derived signals2. Identifying the source and nature of these pro-regenerative cues has been hampered by an inability to visualise the complex cellular interactions that occur within the wound environment. We therefore developed a zebrafish muscle injury model to systematically capture satellite cell interactions within the injury site, in real time, throughout the repair process. This analysis identified that a specific subset of macrophages ‘dwells’ within the injury, establishing a transient but obligate stem cell niche required for stem cell proliferation. Single cell profiling identified specific signals secreted from dwelling macrophages that include the cytokine, Nicotinamide phosphoribosyltransferase (NAMPT/Visfatin/PBEF). Here we show that NAMPT secretion from the macrophage niche is required for muscle regeneration, acting through the C-C motif chemokine receptor type 5 (CCR5) expressed on muscle stem cells. This analysis reveals that along with their well-described ability to modulate the pro-inflammatory and anti-inflammatory phases of wound repair, specific macrophage populations also provide a transient stem cell-activating niche, directly supplying pro-proliferative cues that govern the timing and rate of muscle stem cell-mediated repair processes.


2016 ◽  
Vol 22 (8) ◽  
pp. 837-838 ◽  
Author(s):  
Matthew Timothy Tierney ◽  
Alessandra Sacco

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