Hepatocyte growth factor installs a survival platform for colorectal cancer cell invasive growth and overcomes p38 MAPK-mediated apoptosis

2006 ◽  
Vol 18 (11) ◽  
pp. 1967-1976 ◽  
Author(s):  
Michela Fassetta ◽  
Lorenza D'Alessandro ◽  
Nadia Coltella ◽  
Maria Flavia Di Renzo ◽  
Andrea Rasola
Keyword(s):  
Colorectal Cancer ◽  
Growth Factor ◽  
Hepatocyte Growth Factor ◽  
P38 Mapk ◽  
Cancer Cell ◽  
Colorectal Cancer Cell ◽  
Invasive Growth ◽  
Hepatocyte Growth

Effect of Geldanamycin on the Glioma Cell Invasion Induced by Hepatocyte Growth Factor

2014 ◽  
Vol 1033-1034 ◽  
pp. 224-228
Author(s):  
Yan Xia Sun ◽  
Guang Yu Zhou ◽  
Li Li ◽  
Xue Mei Han
Keyword(s):  
Growth Factor ◽  
Hepatocyte Growth Factor ◽  
Cell Invasion ◽  
Culture System ◽  
Glioma Cell ◽  
Glioma Cells ◽  
Glioma Cell Line ◽  
Invasive Growth ◽  
Transwell Culture ◽  
Hepatocyte Growth

To investigate the effect of geldanamycin (GDM) on the invasion ability of glioma cell induced by hepatocyte growth factor (HGF). Malignant glioma cell line U251-MG and U87-MG were cultured’and the capability of cell invasion was detected using a Transwell culture system. HGF significantly promoted the invasion ability of both U251-MG and U87-MG cells as compared with the normal control (NC) (P < 0.05). Forty eight hours after GDM treatment, the invasive growth of glioma cells was significantly decreased as compared with either NC or HGF group (P < 0.05). When cells were exposed to GDM plus HGF for 48 h, the cell invasion capability was greatly reduced as compared with either NC or HGF group (P < 0.05). The number of invaded cells in GDM plus HGF group was similar to that of GDM group.GDM can inhibit the invasion ability of glioma cells induced by HGF.

Serum hepatocyte growth factor as a prognostic marker for stage II or III colorectal cancer patients

2009 ◽  
Vol 125 (7) ◽  
pp. 1657-1662 ◽  
Author(s):  
Yuji Toiyama ◽  
Chikao Miki ◽  
Yasuhiro Inoue ◽  
Yoshinaga Okugawa ◽  
Kouji Tanaka ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Growth Factor ◽  
Hepatocyte Growth Factor ◽  
Cancer Patients ◽  
Prognostic Marker ◽  
Stage Ii ◽  
Colorectal Cancer Patients ◽  
Hepatocyte Growth

scholarly journals p38 MAPK Is Involved in Activin A- and Hepatocyte Growth Factor-mediated Expression of Pro-endocrine Gene Neurogenin 3 in AR42J-B13 Cells

2003 ◽  
Vol 278 (24) ◽  
pp. 21693-21700 ◽  
Author(s):  
Takeshi Ogihara ◽  
Hirotaka Watada ◽  
Rei Kanno ◽  
Fuki Ikeda ◽  
Takashi Nomiyama ◽  
...  
Keyword(s):  
Growth Factor ◽  
Hepatocyte Growth Factor ◽  
P38 Mapk ◽  
Activin A ◽  
Neurogenin 3 ◽  
Hepatocyte Growth
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