Sterol regulatory element binding protein (SREBP) -1 mediates oxidized low-density lipoprotein (oxLDL) induced macrophage foam cell formation through NLRP3 inflammasome activation

2019 ◽  
Vol 53 ◽  
pp. 316-326 ◽  
Author(s):  
Johnna F. Varghese ◽  
Rohit Patel ◽  
Umesh C.S. Yadav
Keyword(s):  
Foam Cell ◽  
Regulatory Element ◽  
Low Density Lipoprotein ◽  
Cell Formation ◽  
Density Lipoprotein ◽  
Foam Cell Formation ◽  
Inflammasome Activation ◽  
Macrophage Foam Cell ◽  
Element Binding Protein ◽  
Sterol Regulatory Element

Acrolein-conjugated low-density lipoprotein induces macrophage foam cell formation

2013 ◽  
Vol 227 (1) ◽  
pp. 51-57 ◽  
Author(s):  
Kenta Watanabe ◽  
Yuki Nakazato ◽  
Ryotaro Saiki ◽  
Kazuei Igarashi ◽  
Mitsukazu Kitada ◽  
...  
Keyword(s):  
Foam Cell ◽  
Low Density Lipoprotein ◽  
Cell Formation ◽  
Density Lipoprotein ◽  
Foam Cell Formation ◽  
Low Density ◽  
Macrophage Foam Cell

scholarly journals Evidence of Macrophage Foam Cell Formation by Very Low-Density Lipoprotein Receptor

Circulation ◽  
2001 ◽  
Vol 103 (8) ◽  
pp. 1142-1147 ◽  
Author(s):  
Shotaro Kosaka ◽  
Sadao Takahashi ◽  
Katsuhiko Masamura ◽  
Hideo Kanehara ◽  
Juro Sakai ◽  
...  
Keyword(s):  
Foam Cell ◽  
Low Density Lipoprotein ◽  
Cell Formation ◽  
Density Lipoprotein ◽  
Foam Cell Formation ◽  
Very Low Density Lipoprotein ◽  
Low Density ◽  
Lipoprotein Receptor ◽  
Macrophage Foam Cell ◽  
Density Lipoprotein Receptor

Celery Seed Extract Blocks Peroxide Injury in Macrophages via Notch1/NF-κB Pathway

2015 ◽  
Vol 43 (03) ◽  
pp. 443-455 ◽  
Author(s):  
Yanhong Si ◽  
Shoudong Guo ◽  
Yongqi Fang ◽  
Shucun Qin ◽  
Furong Li ◽  
...  
Keyword(s):  
Laser Scanning ◽  
Foam Cell ◽  
Low Density Lipoprotein ◽  
Cell Formation ◽  
Density Lipoprotein ◽  
Seed Extract ◽  
Foam Cell Formation ◽  
Macrophage Foam Cell ◽  
Raw264.7 Macrophages ◽  
Celery Seed

Oxidized low-density lipoprotein (ox-LDL)-induced macrophage foam cell formation and injury is one of the major atherogenic factors. This study is aimed to investigate the protective effect of celery seed extract (CSE) on ox-LDL-induced injury of macrophages and the underlying signaling pathway. RAW264.7 macrophages were pre-incubated with CSE for 24 h, followed by stimulation with ox-LDL. Oil red O staining and enzymatic colorimetry indicated CSE significantly lessened lipid droplets and total cholesterol (TC) content in ox-LDL-injured macrophages. ELISA revealed that CSE decreased the secretion of inflammatory cytokine TNF-α and IL-6 by 12–27% and 5–15% respectively. MTT assay showed CSE promoted cell viability by 16–40%. Cell apoptosis was also analyzed by flow cytometry and laser scanning confocal microscope and the data indicated CSE inhibited ox-LDL-induced apoptosis of macrophages. Meanwhile, western blot analysis showed CSE suppressed NF-κBp65 and notch1 protein expressions stimulated by ox-LDL in macrophages. These results suggest that CSE inhibits ox-LDL-induced macrophages injury via notch1/NF-κB pathway.

scholarly journals Fluid-Phase Pinocytosis of Native Low Density Lipoprotein Promotes Murine M-CSF Differentiated Macrophage Foam Cell Formation

PLoS ONE ◽  
2013 ◽  
Vol 8 (3) ◽  
pp. e58054 ◽  
Author(s):  
Manoj K. Barthwal ◽  
Joshua J. Anzinger ◽  
Qing Xu ◽  
Thomas Bohnacker ◽  
Matthias P. Wymann ◽  
...  
Keyword(s):  
Foam Cell ◽  
Low Density Lipoprotein ◽  
Cell Formation ◽  
Density Lipoprotein ◽  
Fluid Phase ◽  
Foam Cell Formation ◽  
Low Density ◽  
Macrophage Foam Cell ◽  
Native Low Density Lipoprotein
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