scholarly journals Integrated Epigenome, Exome, and Transcriptome Analyses Reveal Molecular Subtypes and Homeotic Transformation in Uterine Fibroids

Cell Reports ◽  
2019 ◽  
Vol 29 (12) ◽  
pp. 4069-4085.e6 ◽  
Author(s):  
Jitu Wilson George ◽  
Huihui Fan ◽  
Benjamin Johnson ◽  
Tyler James Carpenter ◽  
Kelly Katherine Foy ◽  
...  
Keyword(s):  
Molecular Subtypes ◽  
Uterine Fibroids ◽  
Homeotic Transformation ◽  
Transcriptome Analyses

scholarly journals Integrated epigenome, exome and transcriptome analyses reveal molecular subtypes and homeotic transformation in uterine fibroids

2018 ◽  
Author(s):  
Jitu W. George ◽  
Huihui Fan ◽  
Benjamin K. Johnson ◽  
Anindita Chatterjee ◽  
Amanda L. Patterson ◽  
...  
Keyword(s):  
Epigenetic Modification ◽  
Uterine Fibroids ◽  
Unknown Etiology ◽  
Integrated Analysis ◽  
Homeotic Transformation ◽  
Expression Of Genes ◽  
Whole Exome ◽  
Smooth Muscle Tumors ◽  
The Usa ◽  
Transcriptome Analyses

ABSTRACTUterine fibroids are benign myometrial smooth muscle tumors of unknown etiology that when symptomatic are the most common indication for hysterectomy in the USA. We conducted an integrated analysis of fibroids and adjacent normal myometria by whole exome sequencing, Infinium MethylationEPIC array, and RNA-sequencing. Unsupervised clustering by DNA methylation segregated normal myometria from fibroids, and further separated the fibroids into subtypes marked byMED12mutation,HMGA2activation (HMGA2hi) andHMGA1activation (HMGA1hi). Upregulation ofHMGA2expression inHMGA2hi fibroids did not always appear to be dependent on translocation, as has been historically described, and was associated with hypomethylation in theHMGA2gene body. Furthermore, we found that expression ofHOXA13was highly upregulated in fibroids and that overexpression ofHOXA13in a myometrial cell line induced expression of genes classically associated with uterine fibroids. Transcriptome analyses of the most differentially expressed genes between cervix and myometrium also showed that uterine fibroids and normal cervix clustered together and apart from normal myometria. Together, our integrated analysis shows a role for epigenetic modification in fibroid biology and strongly suggests that homeotic transformation of myometrium cells to a more cervical phenotype is important for the etiology of the disease.

372: Identification of Molecular Subtypes and Prognostic Markers in Renal Cell Carcinomas Using CDNA Microarray

2005 ◽  
Vol 173 (4S) ◽  
pp. 102-102 ◽  
Author(s):  
Hongjuan Zhao ◽  
Eric Bair ◽  
Robert Tibshirani ◽  
Börje Ljungberg ◽  
James D. Brooks
Keyword(s):  
Cdna Microarray ◽  
Renal Cell ◽  
Prognostic Markers ◽  
Molecular Subtypes ◽  
Renal Cell Carcinomas

History of uterine fibroids reported by California women

2008 ◽  
Author(s):  
Zipora Weinbaum ◽  
Terri Throfinnson
Keyword(s):  
Uterine Fibroids ◽  
History Of

Ayurvedic management of uterine fibroids: a case report

2019 ◽  
Vol 12 (6) ◽  
pp. 257-260
Author(s):  
Shubhashree MN ◽  
Doddamani SH ◽  
Bhavya BM ◽  
Bharali B K
Keyword(s):  
Case Report ◽  
Uterine Fibroids

Modern approaches to the prevention and treatment of alterations in reproductive health in women with somatoform disorders and autonomic homeostasis

2016 ◽  
pp. 98-101
Author(s):  
Vl.V. Podolsky ◽  
◽  
V.V. Podolsky ◽  
Keyword(s):  
Reproductive Health ◽  
Hormonal Regulation ◽  
Preventive Measures ◽  
Somatoform Disorders ◽  
Emotional Health ◽  
Uterine Fibroids ◽  
Reproductive Function ◽  
Epidemiological Studies ◽  
Prevention And Treatment ◽  
Artificial Abortion

The objective: the developing of a system of preventive measures and principles of pregravid preparation for women with somatoform disorders and violation of autonomic homeostasis (VAH), in which observed changes in reproductive health (CRH) in the shape of states after undergoing artificial abortion, infertility and uterine fibroids. Patients and methods. Conducted clinical and epidemiological studies in the population of women of fertile age (WFA) allowed identifying for further examination of women with CRH in the form of state after undergoing artificial abortion, infertility and uterine fibroids in women with VAH. Further women were examined, in particular the conducted clinical and instrumental methods of research; determined the state of autonomic homeostasis and psycho emotional health of the biotopes of the organism, immunity; analyzed the hormonal regulation of the menstrual cycle; performed genetic studies and determined the morphofunctional state of reproductive system. Results. The most frequent complications during pregnancy in women who had CRH in history in the form of abortions, infertility and uterine fibroids and in the background of the PAF, there was a threat of interruption of pregnancy (often in I and II trimester – 56%) and preterm delivery (21%). The study of the catamnesis of further reproductive health found that in the case of well-conducted therapeutic measures in women undergoing artificial abortion, had infertility and uterine leiomyoma in the background of VAH, restore reproductive function, and in 82% of cases occurred a pregnancy. Conclusion. The the provided study of reproductive health, and state of various organs and systems of fertile aged women with somatoform disorders and violations of the autonomic homeostasis allowed to develop preventive measures for these women and pregravid preparation with the inclusion to the therapy Magnesium and vitamins (Magne-В6®). Key words: somatoform disorders, violation of autonomic homeostasis, changes in reproductive health, prevention and treatment, women of fertile age, Magne-В6®.

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