Metabolic compensation activates pro-survival mTORC1 signaling upon 3-phosphoglycerate dehydrogenase inhibition in osteosarcoma

Richa Rathore; Katharine E. Caldwell; Charles Schutt; Caitlyn B. Brashears; Bethany C. Prudner; William R. Ehrhardt; Cheuk Hong Leung; Heather Lin; Najat C. Daw; Hannah C. Beird; Abigail Giles; Wei-Lien Wang; Alexander J. Lazar; John S.A. Chrisinger; J. Andrew Livingston; Brian A. Van Tine

doi:10.1016/j.celrep.2020.108678

Metabolic compensation activates pro-survival mTORC1 signaling upon 3-phosphoglycerate dehydrogenase inhibition in osteosarcoma

Cell Reports ◽

10.1016/j.celrep.2020.108678 ◽

2021 ◽

Vol 34 (4) ◽

pp. 108678

Author(s):

Richa Rathore ◽

Katharine E. Caldwell ◽

Charles Schutt ◽

Caitlyn B. Brashears ◽

Bethany C. Prudner ◽

...

Keyword(s):

Metabolic Compensation ◽

Mtorc1 Signaling ◽

Phosphoglycerate Dehydrogenase

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Decision letter for "FAK promotes early osteoprogenitor cell proliferation by enhancing mTORC1 signaling"

10.1002/jbmr.4029/v1/decision1 ◽

2019 ◽

Keyword(s):

Cell Proliferation ◽

Osteoprogenitor Cell ◽

Mtorc1 Signaling

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SAD-A Promotes Pancreatic ß-Cell Proliferation by Regulating ß-Cell Cycle as a Downstream Target of mTORC1 Signaling

Diabetes ◽

10.2337/db18-53-or ◽

2018 ◽

Vol 67 (Supplement 1) ◽

pp. 53-OR

Author(s):

JIA NIE ◽

NICOLAS MUSI ◽

YUGUANG SHI

Keyword(s):

Cell Cycle ◽

Cell Proliferation ◽

Downstream Target ◽

Mtorc1 Signaling

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2195-P: Identification of the Regulatory Mechanism of mTORC1 Signaling Activity in Pancreatic Beta Cells in GCN2 Knockout Mice

Diabetes ◽

10.2337/db19-2195-p ◽

2019 ◽

Vol 68 (Supplement 1) ◽

pp. 2195-P

Author(s):

MICHIYO KUDO ◽

SHUN-ICHIRO ASAHARA ◽

AYUMI KANNO ◽

YOSHIAKI KIDO

Keyword(s):

Beta Cells ◽

Knockout Mice ◽

Pancreatic Beta Cells ◽

Regulatory Mechanism ◽

Mtorc1 Signaling ◽

Signaling Activity

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Faculty Opinions recommendation of mTORC1 signaling under hypoxic conditions is controlled by ATM-dependent phosphorylation of HIF-1α.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.6741956.6906054 ◽

2010 ◽

Author(s):

Enrico Avvedimento

Keyword(s):

Hypoxic Conditions ◽

Mtorc1 Signaling

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Faculty Opinions recommendation of Differential response of skeletal muscles to mTORC1 signaling during atrophy and hypertrophy.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.717990746.793473239 ◽

2013 ◽

Author(s):

Aaron Russell

Keyword(s):

Skeletal Muscles ◽

Differential Response ◽

Mtorc1 Signaling ◽

Atrophy And Hypertrophy

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Faculty Opinions recommendation of Rheb/mTORC1 signaling promotes kidney fibroblast activation and fibrosis.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718008927.793476846 ◽

2013 ◽

Author(s):

Ines Armando

Keyword(s):

Fibroblast Activation ◽

Mtorc1 Signaling ◽

Kidney Fibroblast

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Faculty Opinions recommendation of REDD1 enhances protein phosphatase 2A-mediated dephosphorylation of Akt to repress mTORC1 signaling.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718505432.793499740 ◽

2014 ◽

Author(s):

Rony Seger ◽

Zhong Yao

Keyword(s):

Protein Phosphatase ◽

Protein Phosphatase 2A ◽

Mtorc1 Signaling ◽

Phosphatase 2A

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Faculty Opinions recommendation of Effect of age on basal muscle protein synthesis and mTORC1 signaling in a large cohort of young and older men and women.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.725380242.793518281 ◽

2016 ◽

Author(s):

James Timmons ◽

Iain Gallagher

Keyword(s):

Protein Synthesis ◽

Muscle Protein ◽

Muscle Protein Synthesis ◽

Older Men ◽

Large Cohort ◽

Men And Women ◽

Mtorc1 Signaling ◽

Older Men And Women ◽

Effect Of Age

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Faculty Opinions recommendation of Metformin Inhibits Hepatic mTORC1 Signaling via Dose-Dependent Mechanisms Involving AMPK and the TSC Complex.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.727210868.793539922 ◽

2017 ◽

Author(s):

Anthony Means ◽

Brian York ◽

Maricarmen Planas-Silva

Keyword(s):

Mtorc1 Signaling ◽

Dose Dependent

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Faculty Opinions recommendation of Critical roles of mTORC1 signaling and metabolic reprogramming for M-CSF-mediated myelopoiesis.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.727891058.793535319 ◽

2017 ◽

Author(s):

Lisa Borghesi

Keyword(s):

Metabolic Reprogramming ◽

Mtorc1 Signaling

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