Zinc-releasing calcium phosphate cements for bone substitute materials

2016 ◽  
Vol 42 (15) ◽  
pp. 17310-17316 ◽  
Author(s):  
V. Graziani ◽  
M. Fosca ◽  
A.A. Egorov ◽  
Yu.V. Zobkov ◽  
A.Yu. Fedotov ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Bone Substitute ◽  
Calcium Phosphate Cements ◽  
Bone Substitute Materials ◽  
Substitute Materials

Novel injectable calcium phosphate/chitosan composites for bone substitute materials

2006 ◽  
Vol 2 (5) ◽  
pp. 557-565 ◽  
Author(s):  
Hua Liu ◽  
Hong Li ◽  
Wenjun Cheng ◽  
Yuan Yang ◽  
Minying Zhu ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Bone Substitute ◽  
Bone Substitute Materials ◽  
Substitute Materials

Development of calcium phosphate cement using chitosan and citric acid for bone substitute materials

Biomaterials ◽  
2002 ◽  
Vol 23 (4) ◽  
pp. 1091-1101 ◽  
Author(s):  
Atsuro Yokoyama ◽  
Satoru Yamamoto ◽  
Takao Kawasaki ◽  
Takao Kohgo ◽  
Masanori Nakasu
Keyword(s):  
Citric Acid ◽  
Calcium Phosphate ◽  
Calcium Phosphate Cement ◽  
Bone Substitute ◽  
Bone Substitute Materials ◽  
Substitute Materials

New Generation of Synthetic, Bioresorbable and Injectable Calcium Phosphate Bone Substitute Materials: Alpha-bsm®, Beta-bsmTM and Gamma-bsmTM

2009 ◽  
Vol 2 ◽  
pp. 39-55 ◽  
Author(s):  
Aliassghar Tofighi ◽  
A. Rosenberg ◽  
M. Sutaria ◽  
S. Balata ◽  
J. Chang
Keyword(s):  
Compressive Strength ◽  
Calcium Phosphate ◽  
Body Temperature ◽  
Calcium Phosphate Cement ◽  
Bone Substitute ◽  
Room Temperature ◽  
Phosphate Solution ◽  
Bone Substitute Materials ◽  
Low Crystalline ◽  
Substitute Materials

Alpha-bsm® is a first generation self-setting, injectable and moldable apatitic calcium phosphate cement (CPC) based on amorphous calcium phosphate (ACP). ACP was prepared using low temperature double decomposition technique, from a calcium solution (0.16 M), and phosphate solution (0.26 M) in a basic (pH~13) media. ACP was than stabilized using three crystal growth inhibitors (CO32-, Mg2+, P2O74-), freeze-dried, and heated (450 °C, 1h) to remove additional moisture and some inhibitors. Dicalcium phosphate dehydrate (DCPD) was also prepared using wet chemistry at room temperature from calcium and phosphate solution, respectively, 0.3 M and 0.15 M. ACP and DCPD powder were combined at a 1:1 ratio and ground to produce Alpha-bsm® bone cement. The cement is supplied as a powder and when mixed with an appropriate amount (0.8 ml/g) of physiological saline at room temperature, forms an injectable putty-like paste. The paste has a working time of about 45 minutes at room temperature, when stored in a moist environment. The setting reaction proceeds isothermically at body temperature (37°C) in less than 20 minutes, forming a hardened, porous (total porosity 50 to 60%), low crystalline (40% comparing with HA), apatitic calcium phosphate cement with a compressive strength range of 10 to 12 MPa. Extensive pre-clinical studies (rabbit radius critical sized defect, canine tibia osteotomy, sheep tibia, primate fibula fracture healing, and primate fibula critical size defect) demonstrate that Alpha-bsm® undergoes remodeling in conjunction with new bone formation. The next generation of Bone Substitute Materials (Beta-bsmTM and Gamma-bsm TM) are formulated based on the Alpha-bsm® chemistry but differ in powder processing (e.g. milling) technique. These materials are also self-setting, injectable and/or moldable apatitic calcium phosphate cements with improved handling and mechanical properties. The setting & hardening reaction of these new CPCs proceeds isothermically in less than 5 minutes at 37°C and once hardened demonstrate a compressive strength of 30 to 50 MPa. The final product (after full conversion) is a low crystalline (40% compared with Hydroxyapatite), calcium deficient (Ca/P atomic ratio = 1.45) carbonated apatite similar to the composition and structure of natural bone mineral (crystal size: length = 26 nm, width thickness = 8 nm). A desirable feature of these cements is their high surface chemistry (with specific surface area of about 180-200 m2/g) which is ideal for remodeling and controlled release of growth factors. A pilot rabbit critically sized femoral defect study comparing the three synthetic family products demonstrate that they share similar remodeling and resorption characteristics up to 52 weeks. Physico-chemical and mechanical performance of these next generation CPCs are favorable when compared with existing CPCs in the market, specifically material working time (at room temperature), cohesivity in a wet environment and fast setting & hardening rate (at body temperature).

Effect of Silicon-Doped Calcium Phosphate Bone Substitutes on Bone Formation and Osteoblastic Phenotype Expression In Vivo

2014 ◽  
Vol 614 ◽  
pp. 31-34 ◽  
Author(s):  
Christine Knabe ◽  
Marco Lopez Heredia ◽  
Dirk Barnemitz ◽  
Antje Genzel ◽  
Fabian Peters ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Bone Formation ◽  
Bone Substitute ◽  
Bone Repair ◽  
Critical Size ◽  
Potassium Phosphate ◽  
Critical Size Defects ◽  
Bone Substitute Materials ◽  
Silicon Doped ◽  
Substitute Materials

This study evaluates the effect of two novel particulate silicon-doped calcium phosphate graft materials as compared to the currently clinically used material β-TCP on osteogenesis and bone formation after implantation in critical-size defects the sheep scapula. These materials were developed in order to create biodegradable bone substitute materials that degrade rapidly, but still stimulate osteogenesis at the same time, thereby resulting in bone repair and regeneration with fully functional bone tissue. All bone substitute materials studied facilitated excellent bony regeneration of critical-size defects in the sheep scapula. Of the three grafting materials studied, the calcium alkali orthophosphate material with the crystalline phase Ca2KNa (PO4)2, with a small amorphous portion containing magnesium potassium phosphate and a small addition of sodium magnesium silicate had the greatest stimulatory effect on bone formation and expression of osteogenic markers, while exhibiting the highest biodegradability.

Calcium phosphate-based composites as injectable bone substitute materials: A review

2010 ◽  
Vol 9999B ◽  
pp. NA-NA ◽  
Author(s):  
Kah Ling Low ◽  
Soon Huat Tan ◽  
Sharif Hussein Sharif Zein ◽  
Judith A. Roether ◽  
Viviana Mouriño ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Bone Substitute ◽  
Bone Substitute Materials ◽  
Substitute Materials

Influence of Phase Composition on Degradation and Resorption of Biphasic Calcium Phosphate Ceramics

2007 ◽  
Vol 361-363 ◽  
pp. 1043-1046 ◽  
Author(s):  
Helmar Mayr ◽  
Susanne Schlüfter ◽  
Rainer Detsch ◽  
Günter Ziegler
Keyword(s):  
Phase Composition ◽  
Calcium Phosphate ◽  
Bone Substitute ◽  
Biphasic Calcium Phosphate ◽  
Microscopic Analysis ◽  
Raw 264.7 Cells ◽  
Degradation Behaviour ◽  
Calcium Phosphate Ceramics ◽  
Bone Substitute Materials ◽  
Substitute Materials

In this study the degradation behaviour of pure hydroxyapatite (HA), pure tricalcium phosphate (β-TCP) and four biphasic calcium phosphate ceramics was studied to gain information about the influence of the phase composition on this property with the aim to tailor individually adapted bone substitute materials. The chemical dissolution of each ceramic composition was measured by its release of calcium ions into a buffered solution. With decreasing HA content in the ceramics the degradation rate increased. Cell experiments were carried out with stimulated osteoclast-like RAW 264.7 cells. Using biochemical, genetic and microscopic analysis, the differentiation of the cells on the ceramic samples was studied. The monocytic precursor cells differentiated into osteoclast-like cells on all ceramics. The strongest cell differentiation into osteoclast-like cells was found on ceramics with HA/β-TCP ratios of 80/20, 60/40 and 40/60. Cells on these ceramics had many nuclei and the largest cell size. As a result of resorption, lacunas were found on all ceramics except β-TCP. All these experimental results proved the influence of the phase composition on degradation and resorption of calcium phosphate ceramics. Biphasic calcium phosphate ceramics with HA/β-TCP ratios of 80/20 and 60/40 exhibited the most promising properties to serve as synthetic bone substitute materials because for integration in the physiological bone remodeling process the implanted bone substitute materials should have optimized dissolution and resorption properties.

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