2-Hydroxyoleic acid regulates cell signaling pathways by a specific modification of plasma membrane biophysical properties

2011 ◽  
Vol 164 ◽  
pp. S11
Author(s):  
Gwendolyn Barceló-Coblijn ◽  
M. Laura Martin ◽  
Rodrigo F.M. de Almeida ◽  
Maria Antònia Noguera-Salvà ◽  
Amaia Marcilla-Etxenike ◽  
...  
Keyword(s):  
Plasma Membrane ◽  
Cell Signaling ◽  
Signaling Pathways ◽  
Biophysical Properties ◽  
Specific Modification ◽  
Cell Signaling Pathways

Palmitoylation of prohibitin at cysteine 69 facilitates its membrane translocation and interaction with Eps 15 homology domain protein 2 (EHD2)

2010 ◽  
Vol 88 (3) ◽  
pp. 553-558 ◽  
Author(s):  
Sudharsana Rao Ande ◽  
Suresh Mishra
Keyword(s):  
Plasma Membrane ◽  
Cell Signaling ◽  
Signaling Pathways ◽  
Tyrosine Phosphorylation ◽  
Lipid Raft ◽  
Plasma Membranes ◽  
Cell Types ◽  
Membrane Translocation ◽  
Domain Protein ◽  
Cell Signaling Pathways

Plasma membrane translocation of specific cytosolic proteins plays an important role in cell signaling pathways. We have recently shown that prohibitin (PHB) , a protein present in the plasma membranes of various cell types, interacts with Eps 15 homology domain protein 2 (EHD2), a lipid raft protein. However, the mechanism involved in membrane translocation of PHB is not known.We report that PHB undergoes palmitoylation at cysteine 69 (Cys69), and that this palmitoylation is required for PHB's membrane translocation. Furthermore, we demonstrate that membrane translocation of PHB facilitates tyrosine phosphorylation and its interaction with EHD2. Thus, the palmitoylation and membrane translocation of PHB and its interaction with EHD2 may play a role in cell signaling.

Cell signaling pathways as molecular targets to eliminate AML stem cells

2021 ◽  
Vol 160 ◽  
pp. 103277
Author(s):  
Ana Carolina B. da C. Rodrigues ◽  
Rafaela G.A. Costa ◽  
Suellen L.R. Silva ◽  
Ingrid R.S.B. Dias ◽  
Rosane B. Dias ◽  
...  
Keyword(s):  
Stem Cells ◽  
Cell Signaling ◽  
Signaling Pathways ◽  
Molecular Targets ◽  
Cell Signaling Pathways

scholarly journals Dietary polyphenols suppress chronic inflammation by modulation of multiple inflammation-associated cell signaling pathways

2021 ◽  
pp. 108634
Author(s):  
Ibrahim Jantan ◽  
Md. Areeful Haque ◽  
Laiba Arshad ◽  
Hemavathy Harikrishnan ◽  
Abdi Wira Septama ◽  
...  
Keyword(s):  
Cell Signaling ◽  
Signaling Pathways ◽  
Chronic Inflammation ◽  
Dietary Polyphenols ◽  
Cell Signaling Pathways

RAGE Activation by S100P in Colon Cancer Stimulates Growth, Migration, and Cell Signaling Pathways

2007 ◽  
Vol 50 (8) ◽  
pp. 1230-1240 ◽  
Author(s):  
Maren K. Fuentes ◽  
Shraddha S. Nigavekar ◽  
Thiruvengadam Arumugam ◽  
Craig D. Logsdon ◽  
Ann Marie Schmidt ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cell Signaling ◽  
Signaling Pathways ◽  
Cell Signaling Pathways

scholarly journals The crosstalk between EGF, IGF, and Insulin cell signaling pathways - computational and experimental analysis

2009 ◽  
Vol 3 (1) ◽  
pp. 88 ◽  
Author(s):  
Rafal Zielinski ◽  
Pawel F Przytycki ◽  
Jie Zheng ◽  
David Zhang ◽  
Teresa M Przytycka ◽  
...  
Keyword(s):  
Cell Signaling ◽  
Signaling Pathways ◽  
Experimental Analysis ◽  
Cell Signaling Pathways
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