581 Arterial haemoglobin saturation reflected by changes in blood oxygen level-dependent signal intensity of the left ventricular blood pool

2011 ◽  
Vol 27 (5) ◽  
pp. S272
Author(s):  
K. Fischer ◽  
D.P. Guensch ◽  
J.A. Flewitt ◽  
M.G. Friedrich
Keyword(s):  
Signal Intensity ◽  
Blood Oxygen Level Dependent ◽  
Blood Pool ◽  
Left Ventricular ◽  
Blood Oxygen ◽  
Oxygen Level ◽  
Blood Oxygen Level ◽  
Dependent Signal

Utility of blood oxygen level dependent magnetic resonance imaging in the evaluation of tissue oxygenation patterns of prostate cancer.

2013 ◽  
Vol 31 (6_suppl) ◽  
pp. 198-198
Author(s):  
Bishoy A. Gayed ◽  
Rami Hallac ◽  
Ramy F. Youssef ◽  
Franto Francis ◽  
Qing Yuan ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Signal Intensity ◽  
Tissue Oxygenation ◽  
Blood Oxygen Level Dependent ◽  
Preoperative Imaging ◽  
Blood Oxygen ◽  
Oxygen Level ◽  
Blood Oxygen Level ◽  
Bold Mri ◽  
Pathologic Features

198 Background: Tumor hypoxia is associated with worse pathologic features and oncological outcomes. Blood Oxygen Level Dependent (BOLD) MRI evaluates changes in endogenous contrast generated by paramagnetic deoxy-hemoglobin to non-invasively evaluate tissue oxygenation. Prior attempts using carbogen-based (95%O2 + 5%CO2) imaging were limited by patient tolerance. We present the first-in-man evaluation of a novel oxygen breathing challenge technique to monitor tissue oxygenation with BOLD MRI in patients with prostate cancer. Methods: Following IRB approval, 10 patients with clinically localized prostate cancer scheduled for radical prostatectomy underwent preoperative imaging with a 3-Tesla MRI scanner. Images were acquired using a 6-element SENSE body transmit coil and endorectal receive coil. T2* signal intensity is dependent on the concentration of deoxy-hemoglobin. Signal intensity measurements were obtained at different time points. Shorter T2* times imply the presence of hypoxia. Dynamic T2* maps were acquired while subjects breathed air for 2 mins followed by oxygen (15 l/min). Results: 10 patients (median age: 59 years (range 48-73), median PSA 6.9 ng/ml (range 2.5-25), with prostate cancer (Gleason sum 6- 7, 8-9 in 7 and 3 patients respectively) underwent BOLD MRI within 3 weeks of definitive management with a robotic assisted laparoscopic prostatectomy. All patients tolerated BOLD MRI with oxygen challenge without difficulty. Evaluation of BOLD MRI revealed wide variation in T2* values within the prostates from a median of 14.7 ± .71 ms to 44.5 ± 3.3ms. Surrounding muscle T2* values were similar for all patients, indicating that heterogeneous values were specific to each patient’s prostate. Shorter T2* values were seen in Gleason 6-7 than Gleason 8- 9 cancers, indicating more hypoxic areas in these tumors. HIF-1α staining was strongly positive in all tumors. Conclusions: BOLD MRI with oxygen challenge is well tolerated in patients and is a feasible noninvasive technique to study tissue oxygenation in tumors. Differential oxygenation patterns of prostates appear to correlate with pathological features. Further testing is needed to validate these findings.

scholarly journals Aberrant blood-oxygen-level-dependent signal oscillations across frequency bands characterize the alcoholic brain

2017 ◽  
Vol 23 (2) ◽  
pp. 824-835 ◽  
Author(s):  
Jui-Yang Hong ◽  
Eva M. Müller-Oehring ◽  
Adolf Pfefferbaum ◽  
Edith V. Sullivan ◽  
Dongjin Kwon ◽  
...  
Keyword(s):  
Blood Oxygen Level Dependent ◽  
Blood Oxygen ◽  
Oxygen Level ◽  
Blood Oxygen Level ◽  
Frequency Bands ◽  
Dependent Signal

scholarly journals Blood oxygen level-dependent signal responses in corticolimbic ‘emotions’ circuitry of lactating rats facing intruder threat to pups

2009 ◽  
Vol 30 (5) ◽  
pp. 934-945 ◽  
Author(s):  
Benjamin C. Nephew ◽  
Martha K. Caffrey ◽  
Ada C. Felix-Ortiz ◽  
Craig F. Ferris ◽  
Marcelo Febo
Keyword(s):  
Blood Oxygen Level Dependent ◽  
Blood Oxygen ◽  
Oxygen Level ◽  
Blood Oxygen Level ◽  
Dependent Signal

scholarly journals Cognitive control associated with irritability induction: an autobiographical recall fMRI study

2010 ◽  
Vol 32 (2) ◽  
pp. 109-118 ◽  
Author(s):  
Carlos T. Cerqueira ◽  
Jorge R. C. Almeida ◽  
João R. Sato ◽  
Clarice Gorenstein ◽  
Valentim Gentil ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Cognitive Control ◽  
Blood Oxygen Level Dependent ◽  
Anterior Cingulate ◽  
Auditory Presentation ◽  
Imaging Method ◽  
Blood Oxygen ◽  
Oxygen Level ◽  
Blood Oxygen Level ◽  
Dependent Signal

OBJECTIVE: Despite the relevance of irritability emotions to the treatment, prognosis and classification of psychiatric disorders, the neurobiological basis of this emotional state has been rarely investigated to date. We assessed the brain circuitry underlying personal script-driven irritability in healthy subjects (n = 11) using functional magnetic resonance imaging. METHOD: Blood oxygen level-dependent signal changes were recorded during auditory presentation of personal scripts of irritability in contrast to scripts of happiness or neutral emotional content. Self-rated emotional measurements and skin conductance recordings were also obtained. Images were acquired using a 1,5T magnetic resonance scanner. Brain activation maps were constructed from individual images, and between-condition differences in the mean power of experimental response were identified by using cluster-wise nonparametric tests. RESULTS: Compared to neutral scripts, increased blood oxygen level-dependent signal during irritability scripts was detected in the left subgenual anterior cingulate cortex, and in the left medial, anterolateral and posterolateral dorsal prefrontal cortex (cluster-wise p-value < 0.05). While the involvement of the subgenual cingulate and dorsal anterolateral prefrontal cortices was unique to the irritability state, increased blood oxygen level-dependent signal in dorsomedial and dorsal posterolateral prefrontal regions were also present during happiness induction. CONCLUSION: Irritability induction is associated with functional changes in a limited set of brain regions previously implicated in the mediation of emotional states. Changes in prefrontal and cingulate areas may be related to effortful cognitive control aspects that gain salience during the emergence of irritability.

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