scholarly journals Gastric bypass surgery is associated with reduced subclinical myocardial injury and greater activation of the cardiac natriuretic peptide system than lifestyle intervention

2020 ◽  
Vol 86 ◽  
pp. 36-44
Author(s):  
Kristin M. Aakre ◽  
Torbjørn Omland ◽  
Njord Nordstrand ◽  
Espen S. Gjevestad ◽  
Kirsten B. Holven ◽  
...  
Keyword(s):  
Gastric Bypass ◽  
Natriuretic Peptide ◽  
Lifestyle Intervention ◽  
Myocardial Injury ◽  
Bypass Surgery ◽  
Gastric Bypass Surgery ◽  
Peptide System ◽  
Natriuretic Peptide System

scholarly journals Obesity-related cardiovascular risk factors after weight loss: a clinical trial comparing gastric bypass surgery and intensive lifestyle intervention

2010 ◽  
Vol 163 (5) ◽  
pp. 735-745 ◽  
Author(s):  
D Hofsø ◽  
N Nordstrand ◽  
L K Johnson ◽  
T I Karlsen ◽  
H Hager ◽  
...  
Keyword(s):  
Risk Factors ◽  
Type 2 Diabetes ◽  
Gastric Bypass ◽  
Cardiovascular Risk ◽  
Cardiovascular Risk Factors ◽  
Lifestyle Intervention ◽  
Bypass Surgery ◽  
Gastric Bypass Surgery ◽  
Surgery Group

ObjectiveWeight reduction improves several obesity-related health conditions. We aimed to compare the effect of bariatric surgery and comprehensive lifestyle intervention on type 2 diabetes and obesity-related cardiovascular risk factors.DesignOne-year controlled clinical trial (ClinicalTrials.gov identifier NCT00273104).MethodsMorbidly obese subjects (19–66 years, mean (s.d.) body mass index 45.1 kg/m2(5.6), 103 women) were treated with either Roux-en-Y gastric bypass surgery (n=80) or intensive lifestyle intervention at a rehabilitation centre (n=66). The dropout rate within both groups was 5%.ResultsAmong the 76 completers in the surgery group and the 63 completers in the lifestyle group, mean (s.d.) 1-year weight loss was 30% (8) and 8% (9) respectively. Beneficial effects on glucose metabolism, blood pressure, lipids and low-grade inflammation were observed in both groups. Remission rates of type 2 diabetes and hypertension were significantly higher in the surgery group than the lifestyle intervention group; 70 vs 33%,P=0.027, and 49 vs 23%,P=0.016. The improvements in glycaemic control and blood pressure were mediated by weight reduction. The surgery group experienced a significantly greater reduction in the prevalence of metabolic syndrome, albuminuria and electrocardiographic left ventricular hypertrophy than the lifestyle group. Gastrointestinal symptoms and symptomatic postprandial hypoglycaemia developed more frequently after gastric bypass surgery than after lifestyle intervention. There were no deaths.ConclusionsType 2 diabetes and obesity-related cardiovascular risk factors were improved after both treatment strategies. However, the improvements were greatest in those patients treated with gastric bypass surgery.

B-type natriuretic peptide increases after gastric bypass surgery and correlates with weight loss

2011 ◽  
Vol 25 (7) ◽  
pp. 2338-2343 ◽  
Author(s):  
Eric M. Changchien ◽  
Shushmita Ahmed ◽  
Francesca Betti ◽  
Jennifer Higa ◽  
Kate Kiely ◽  
...  
Keyword(s):  
Weight Loss ◽  
Gastric Bypass ◽  
Natriuretic Peptide ◽  
Bypass Surgery ◽  
Gastric Bypass Surgery

Does Lifestyle Intervention After Gastric Bypass Surgery Prevent Weight Regain? A Randomized Clinical Trial

2019 ◽  
Vol 29 (11) ◽  
pp. 3419-3431
Author(s):  
Susanna E. Hanvold ◽  
Kathrine J. Vinknes ◽  
Elin B. Løken ◽  
Anette Hjartåker ◽  
Ole Klungsøyr ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Gastric Bypass ◽  
Randomized Clinical Trial ◽  
Lifestyle Intervention ◽  
Weight Regain ◽  
Bypass Surgery ◽  
Gastric Bypass Surgery

scholarly journals Changes in B-Type Natriuretic Peptide and BMI Following Roux-en-Y Gastric Bypass Surgery

Diabetes Care ◽  
2014 ◽  
Vol 37 (4) ◽  
pp. e70-e71 ◽  
Author(s):  
Annis M. Marney ◽  
Nancy J. Brown ◽  
Robyn Tamboli ◽  
Naji Abumrad
Keyword(s):  
Gastric Bypass ◽  
Natriuretic Peptide ◽  
Bypass Surgery ◽  
Gastric Bypass Surgery

scholarly journals Dietary changes in obese patients undergoing gastric bypass or lifestyle intervention: a clinical trial

2012 ◽  
Vol 110 (1) ◽  
pp. 127-134 ◽  
Author(s):  
Line K. Johnson ◽  
Lene F. Andersen ◽  
Dag Hofsø ◽  
Erlend T. Aasheim ◽  
Kirsten B. Holven ◽  
...  
Keyword(s):  
Gastric Bypass ◽  
Lifestyle Intervention ◽  
Dietary Patterns ◽  
Bypass Surgery ◽  
Gastric Bypass Surgery ◽  
Saturated Fat ◽  
Whole Grains ◽  
Morbidly Obese ◽  
Obese Patients ◽  
Surgery Group

We compared changes in the dietary patterns of morbidly obese patients undergoing either laparoscopic gastric bypass surgery or a comprehensive lifestyle intervention programme. The present 1-year non-randomised controlled trial included fifty-four patients in the lifestyle group and seventy-two in the surgery group. Dietary intake was assessed by a validated FFQ. ANCOVA was used to adjust for between-group differences in sex, age, baseline BMI and baseline values of the dependent variables. Intakes of food groups and nutrients did not differ significantly between the intervention groups at baseline. At 1-year follow-up, the lifestyle group had a significantly higher daily intake of fruits and vegetables (561 (sd 198) v. 441 (sd 213) g, P= 0·002), whole grains (63 (sd 24) v. 49 (sd 16) g, P< 0·001) and fibre (28 (sd 6) v. 22 (sd 6) g, P< 0·001) than the surgery group and a lower percentage of total energy intake of saturated fat (12 (sd 3) v. 14 (sd 3) %, P< 0·001). The intake of red meat declined significantly within both groups, vegetables and fish intake were reduced significantly in the surgery group and added sugar was reduced significantly in the lifestyle group. The lifestyle patients improved their dietary patterns significantly (compared with the surgery group), increasing their intake of vegetables, whole grains and fibre and reducing their percentage intake of saturated fat (ANCOVA, all P< 0·001). In conclusion, lifestyle intervention was associated with more favourable dietary 1-year changes than gastric bypass surgery in morbidly obese patients, as measured by intake of vegetables, whole grains, fibre and saturated fat.

scholarly journals B-Type Natriuretic Peptide (BNP) and N-Terminal Pro-BNP in Obese Patients without Heart Failure: Relationship to Body Mass Index and Gastric Bypass Surgery

2006 ◽  
Vol 52 (4) ◽  
pp. 680-685 ◽  
Author(s):  
John V St. Peter ◽  
Guilford G Hartley ◽  
MaryAnn M Murakami ◽  
Fred S Apple
Keyword(s):  
Heart Failure ◽  
Body Mass Index ◽  
Gastric Bypass ◽  
Natriuretic Peptide ◽  
Bypass Surgery ◽  
Gastric Bypass Surgery ◽  
Obese Patients ◽  
Reference Limit ◽  
History Of ◽  
Upper Reference Limit

Abstract Background: Further investigations are warranted to better characterize variables that may confound the clinical interpretation of plasma natriuretic peptide measurements, which are increasingly recognized to have diagnostic and predictive importance. Methods: Blood samples (EDTA plasma) from patients (n = 206) attending clinics for the medical treatment and follow-up of obesity were analyzed for B-type natriuretic peptide (BNP; Bayer assay) and the N-terminal segment of its prohormone (NT-proBNP; Roche assay). Natriuretic peptide concentration ranges were evaluated in those without diagnosis of congestive heart failure (CHF) or chronic kidney disease (CKD). Results: BNP and NT-proBNP were directly correlated (r = 0.87; P = 0.01), with NT-proBNP concentrations higher relative to BNP. Of obese patients without CHF or CKD, 21.6% (40 of 185) had NT-proBNP concentrations greater than the published assay upper reference limit. Concentrations of both natriuretic peptides were higher in patients currently exposed to beta blockers, patients with the diagnosis of hypertension or type 2 diabetes, and patients with a history of gastric bypass surgery. An inverse relationship between body mass index (BMI) and both BNP and NT-proBNP was evident. According to the National Institutes of Health, National Heart, Lung, and Blood Institute classification, more than 95% of the participants sampled in this study were either obesity class 2 (35 kg/m2 &lt; BMI &lt; 39.9 kg/m2) or class 3 (BMI ≥40 kg/m2) Conclusions: A substantial proportion of obese patients without CHF or CKD have concentrations greater than the upper reference limit for NT-proBNP but not for simultaneously measured BNP. A history of gastric bypass surgery appeared to be a significant predictor of increased natriuretic peptide concentrations when assessed in a population of patients with class 2 or 3 obesity.

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