PB 1 In vivo assessment of neurodegeneration in the brain by serial longitudinal diffusion tensor imaging – an application to amyotrophic lateral sclerosis

2017 ◽  
Vol 128 (10) ◽  
pp. e315
Author(s):  
H.P. Müller ◽  
I. Kobor ◽  
U. Bogdahn ◽  
A.C. Ludolph ◽  
A. Khomenko ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Diffusion Tensor Imaging ◽  
Diffusion Tensor ◽  
Longitudinal Diffusion ◽  
The Brain ◽  
Lateral Sclerosis ◽  
In Vivo Assessment

scholarly journals Imaging the pathoanatomy of amyotrophic lateral sclerosis in vivo: targeting a propagation-based biological marker

2017 ◽  
Vol 89 (4) ◽  
pp. 374-381 ◽  
Author(s):  
Jan Kassubek ◽  
Hans-Peter Müller ◽  
Kelly Del Tredici ◽  
Dorothée Lulé ◽  
Martin Gorges ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Rating Scale ◽  
Diffusion Tensor ◽  
Biological Marker ◽  
Longitudinal Diffusion ◽  
Individual Level ◽  
Disease Patterns ◽  
The Individual ◽  
Lateral Sclerosis

ObjectiveNeuropathological studies in amyotrophic lateral sclerosis (ALS) have shown a dissemination in a regional sequence in four anatomically defined patterns. The aim of this retrospective study was to see whether longitudinal diffusion tensor imaging (DTI) data support the pathological findings.MethodsThe application of DTI analysis to fibre structures that are prone to be involved at each neuropathological pattern of ALS was performed in a monocentre sample of 67 patients with ALS and 31 controls that obtained at least one follow-up scan after a median of 6 months.ResultsAt the group level, longitudinal ALS data showed significant differences for the stage-related tract systems. At the individual level, 27% of the longitudinally scanned patients with ALS showed an increase in ALS stage, while the remaining were stable or were at the highest ALS stage. Longitudinal fractional anisotropy changes in the respective tract systems correlated significantly with the slope of the revised ALS functional rating scale.InterpretationThe DTI-based protocol was able to image the disease patterns of ALS in vivo cross-sectionally and longitudinally, in support of DTI as a technical marker to image ALS stages.

Longitudinal Diffusion Tensor Imaging of the Motor Network in Amyotrophic Lateral Sclerosis (P04.157)

Neurology ◽  
2012 ◽  
Vol 78 (Meeting Abstracts 1) ◽  
pp. P04.157-P04.157
Author(s):  
E. Verstraete ◽  
R. Walhout ◽  
M. van de Heuvel ◽  
L. Van den Berg
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Diffusion Tensor Imaging ◽  
Diffusion Tensor ◽  
Longitudinal Diffusion ◽  
Motor Network ◽  
Lateral Sclerosis

scholarly journals Longitudinal diffusion tensor imaging in amyotrophic lateral sclerosis

2012 ◽  
Vol 13 (1) ◽  
pp. 141 ◽  
Author(s):  
Carsten Keil ◽  
Tino Prell ◽  
Thomas Peschel ◽  
Viktor Hartung ◽  
Reinhard Dengler ◽  
...  
Keyword(s):  
Amyotrophic Lateral Sclerosis ◽  
Diffusion Tensor Imaging ◽  
Diffusion Tensor ◽  
Longitudinal Diffusion ◽  
Lateral Sclerosis
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