scholarly journals Hepatitis E Virus, A Diagnosis to Consider in Drug Induced Liver Injury Assessment

2017 ◽  
Vol 39 (8) ◽  
pp. e56-e57
Author(s):  
J. Sanabria-Cabrera ◽  
R. Sanjuan-Jiménez ◽  
C. Stephens ◽  
M. Robles-Díaz ◽  
A. Ortega-Alonso ◽  
...  
Keyword(s):  
Liver Injury ◽  
Hepatitis E Virus ◽  
Hepatitis E ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
Injury Assessment

The role of hepatitis E virus testing in drug-induced liver injury

2007 ◽  
Vol 26 (10) ◽  
pp. 1429-1435 ◽  
Author(s):  
H. R. DALTON ◽  
H. J. FELLOWS ◽  
W. STABLEFORTH ◽  
M. JOSEPH ◽  
P. H. THURAIRAJAH ◽  
...  
Keyword(s):  
Liver Injury ◽  
Hepatitis E Virus ◽  
Hepatitis E ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
Virus Testing

scholarly journals Incidence and prevalence of acute hepatitis E virus infection in patients with suspected Drug‐Induced Liver Injury in the Spanish DILI Registry

2020 ◽  
Author(s):  
Judith Sanabria‐Cabrera ◽  
Rocío Sanjuán‐Jiménez ◽  
Encarnación Clavijo ◽  
Inmaculada Medina‐Cáliz ◽  
Andrés González‐Jiménez ◽  
...  
Keyword(s):  
Liver Injury ◽  
Virus Infection ◽  
Acute Hepatitis ◽  
Hepatitis E Virus ◽  
Hepatitis E ◽  
Suspected Drug ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
Acute Hepatitis E

scholarly journals The Unmet Needs of Hepatitis E Virus Diagnosis in Suspected Drug-Induced Liver Injury in Limited Resource Setting

2021 ◽  
Vol 12 ◽  
Author(s):  
Mohamed A. El-Mokhtar ◽  
Haidi Karam-Allah Ramadan ◽  
Marwa M. Thabet ◽  
Alaa S. Abd-Elkader ◽  
Magdy Fouad ◽  
...  
Keyword(s):  
Liver Injury ◽  
Liver Function ◽  
Hepatitis E Virus ◽  
Limited Resource ◽  
High Sensitivity ◽  
Hepatitis E ◽  
Median Viral Load ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
Resource Setting

Background: Currently, there are no specific biomarkers for drug-induced liver injury (DILI), and the diagnosis of DILI is based mainly on the exclusion of other causes of liver dysfunction and the recognition of potential causative drugs. Hepatitis E virus (HEV) diagnosis is not routinely enrolled in many countries, and HEV infection could be misdiagnosed as DILI.Methodology: We retrospectively analyzed plasma samples (n = 80) collected from suspected DILI for HEV markers such as anti-HEV IgM, anti-HEV IgG, and HEV RNA. Anti-HEV antibodies were assessed using commercial ELISA kits. HEV RNA was tested by RT-qPCR targeting HEV ORF2/3, the receiver operating characteristic (ROC) curve was plotted, and a putative threshold for liver function parameters was determined.Results: Out of 80 samples, 12 samples were positive for anti-HEV IgM and anti-HEV IgG, and HEV RNA was detected in seven samples. The median viral load was 3.46 × 103 IU/ml, and the isolated viruses belonged to HEV genotype 1. The level of liver enzymes such as alanine transaminase (ALT) and aspartate transaminase (AST), but not alkaline phosphatase (ALP), was significantly higher in HEV confirmed cases than in non-HEV confirmed cases. We identified a plasma ALT level of at least 415.5 U/L and AST level of at least 332 U/L; ALT/ALP ratio of at least 5.08 could be used as a guide for the patients diagnosed as DILI to be tested for HEV infection. The previous liver function parameters showed high sensitivity and good specificity.Conclusion: Hepatitis E virus was detected in suspected DILI cases. The diagnosis of DILI is not secure until HEV testing is done. Liver function parameters can be used as a guide for HEV testing in suspected DILI cases in countries with limited resources.

scholarly journals A case of acute hepatitis E virus infection with clinical features indistinguishable from drug-induced liver injury

Kanzo ◽  
2005 ◽  
Vol 46 (8) ◽  
pp. 512-515 ◽  
Author(s):  
Masaya IWAMURO ◽  
Mitsuhiko KAWAGUCHI ◽  
Ryo TERADA ◽  
Toshiya OHSAWA ◽  
Kazuhide YAMAMOTO ◽  
...  
Keyword(s):  
Liver Injury ◽  
Virus Infection ◽  
Acute Hepatitis ◽  
Clinical Features ◽  
Hepatitis E Virus ◽  
Hepatitis E ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
Acute Hepatitis E

Hepatitis E masquerading as drug-induced liver injury

Hepatology ◽  
2012 ◽  
Vol 56 (6) ◽  
pp. 2420-2423 ◽  
Author(s):  
Emerson Y. Chen ◽  
Karl Baum ◽  
William Collins ◽  
Arthur Löve ◽  
Michael Merz ◽  
...  
Keyword(s):  
Liver Injury ◽  
Hepatitis E ◽  
Drug Induced ◽  
Drug Induced Liver Injury

scholarly journals Acute Hepatitis E Infection Accounts for Some Cases of Suspected Drug-Induced Liver Injury

2011 ◽  
Vol 141 (5) ◽  
pp. 1665-1672.e9 ◽  
Author(s):  
Timothy J. Davern ◽  
Naga Chalasani ◽  
Robert J. Fontana ◽  
Paul H. Hayashi ◽  
Petr Protiva ◽  
...  
Keyword(s):  
Liver Injury ◽  
Acute Hepatitis ◽  
Hepatitis E ◽  
Suspected Drug ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
Acute Hepatitis E
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