GLIM vs ESPEN criteria for the diagnosis of early malnutrition in oncological outpatients

This study aims to explore the association between malnutrition diagnosed according to both the Global Leadership Initiative of Malnutrition (GLIM) and the European Society of Clinical Nutrition and Metabolism (ESPEN) criteria and the onset of sarcopenia/severe sarcopenia, diagnosed according to the European Working Group on Sarcopenia in Older People 2 (EWGSOP2) criterion, in the sarcopenia and physical impairment with advancing age (SarcoPhAge) cohort during a four-year follow-up. Adjusted Cox-regression and Kaplan-Meier curves were performed. Among the 534 community-dwelling participants recruited in the SarcoPhAge study, 510 were free from sarcopenia at baseline, of whom 336 had complete data (186 women and 150 men, mean age of 72.5 ± 5.8 years) to apply the GLIM and ESPEN criteria. A significantly higher risk of developing sarcopenia/severe sarcopenia during the four-year follow-up based on the GLIM [sarcopenia: Adjusted hazard ratio (HR) = 3.23 (95% confidence interval (CI) 1.73–6.05); severe sarcopenia: Adjusted HR = 2.87 (95% CI 1.25–6.56)] and ESPEN [sarcopenia: Adjusted HR = 4.28 (95% CI 1.86–9.86); severe sarcopenia: Adjusted HR = 3.86 (95% CI 1.29–11.54)] criteria was observed. Kaplan-Meier curves confirmed this relationship (log rank p < 0.001 for all). These results highlighted the importance of malnutrition since it has been shown to be associated with an approximately fourfold higher risk of developing sarcopenia/severe sarcopenia during a four-year follow-up.

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P188 Evaluation of Global Leadership Initiative on Malnutrition (GLIM) criteria for the diagnosis of malnutrition in patients affected by inflammatory bowel disease (IBD) candidates for elective surgery

Journal of Crohn s and Colitis ◽

10.1093/ecco-jcc/jjz203.317 ◽

2020 ◽

Vol 14 (Supplement_1) ◽

pp. S232-S233

Author(s):

C Fiorindi ◽

M Cricchio ◽

F Ficari ◽

G Alpigiano ◽

S Scaringi ◽

...

Keyword(s):

Body Mass Index ◽

Inflammatory Bowel Disease ◽

Muscle Mass ◽

Body Mass ◽

Bowel Disease ◽

Elective Surgery ◽

Nutritional Risk ◽

Severe Malnutrition ◽

Inflammatory Bowel ◽

Espen Criteria

Abstract Background In inflammatory bowel disease (IBD), malnutrition has been associated with increased postoperative complications incidence, longer hospital stay and higher costs. ESPEN guidelines recommend that all IBD patients must be screened for malnutrition. Recently, so-called GLIM criteria were developed to uniform malnutrition diagnosis. Our aim was to determine the prevalence of malnutrition comparing the different malnutrition criteria. Methods The nutritional status of all IBD patients’ candidates to surgery in our Centre during 2019 was assessed. According to the GLIM criteria, the diagnosis of malnutrition is based on the presence of almost one phenotypic criteria (non-volitional weight loss, low body mass index and reduced muscle mass) and almost one aetiologic criteria (reduced food intake or assimilation; biochemical inflammation). The results were compared with that found adopting ESPEN 2015 criteria for malnutrition to evaluate their concordance. Results Fifty-three consecutive IBD patients [38 Crohn’s disease (CD) and 15 ulcerative colitis (UC)] were evaluated. The average values of Body Mass Index, Free Fat Mass Index ad Phase Angle were 22.69 kg/m2, 17.6 kg/m2 and 5.8° respectively. According to the Nutritional Risk Screening (NRS) test 40% (21 patients) of patients were at high nutritional risk. Forty-five per cent (24 patients) were malnourished according to GLIM criteria (14 with severe malnutrition and 10 with moderate malnutrition), while according to the ESPEN criteria only 26% (14 patients) (Table 1). The correlation between GLIM and ESPEN, calculated with the Cohen’s kappa coefficient (k) was moderate/good (k 0,605). Conclusion GLIM criteria indicate higher prevalence of malnutrition than ESPEN criteria. Interestingly, the same 14 patients malnourished for ESPEN have severe malnutrition (Stage 2) according to GLIM. Furthermore, seven malnourished patients according to GLIM criteria are not considered at nutritional risk according to NRS, probably because it does not consider the muscle mass loss. Patients with CD have a higher prevalence of aetiological factors, while UC patients have a higher prevalence of phenotypic factors. Malnutrition prevalence was higher in UC probably due to the ileostomy present before second-stage surgery 4 months after subtotal colectomy in acute severe cases. The concordance between GLIM and ESPEN 2015 appears moderate/good.

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GLIM versus ESPEN criteria for the diagnosis of early malnutrition in oncological outpatients.

Journal of Clinical Oncology ◽

10.1200/jco.2021.39.15_suppl.e24065 ◽

2021 ◽

Vol 39 (15_suppl) ◽

pp. e24065-e24065

Author(s):

Marta Gascon Ruiz ◽

Diego Casas-Deza ◽

Irene Torres ◽

Maria Zapata-Garcia ◽

Natalia Alonso Marin ◽

...

Keyword(s):

Cancer Patients ◽

Screening Tools ◽

Cross Sectional ◽

Patients With Cancer ◽

Oncological Patients ◽

Single Center Study ◽

Ambulatory Patients ◽

Diagnostic Capacity ◽

Espen Criteria ◽

Baseline Bmi

e24065 Background: Malnutrition is one of the most prevalent problems among oncological patients. It reduces the response to treatments and negatively impacts survival. In 2019, a consensus criteria for diagnosing malnutrition (GLIM criteria) were proposed by most scientific nutrition societies. The objective of our work is 1) to assess the diagnostic capacity of the GLIM criteria in ambulatory patients with cancer and 2) to compare the GLIM with the ESPEN criteria to evaluate the contributions of these new criteria with respect to the existing ones. Methods: Observational, cross-sectional, and single-center study carried out at the Medical Oncology Department in the Lozano Blesa Clinical Hospital in Zaragoza (Spain). One hundred and sixty-five outpatients with tumors in the upper gastrointestinal tract, head and neck, and colorectal locations were recruited. All of them received the MST, MUST, and Nutriscore screening tools along with the ESPEN and GLIM diagnostic criteria. Results: The prevalence of malnutrition was 46.7% according to the GLIM criteria and 21.2% using the ESPEN tool. Patients diagnosed by GLIM had a higher body mass index (BMI, 24.3 kg/m2) and muscle mass (MM, 16.1 kg/m2) than those diagnosed by ESPEN (21.2 kg/m² and 14.3 kg/m2 respectively, both p = 0.001). The MST, MUST, and Nutriscore tools had a higher degree of concordance with GLIM compared to ESPEN (MST 0.53 vs 0.26; MUST 0.36 vs 0.66; Nutriscore 0.28 vs 0.54). Conclusions: The found prevalence of malnutrition in cancer patients is higher using the GLIM instead of ESPEN criteria. This disparity can be explained at least in part by the difficulty of the ESPEN criteria for malnutrition to diagnose patients with high baseline BMI or MM. The use of criteria with greater sensitivity, such as the new GLIM criteria, could help early diagnosis and thus early intervention in cancer patients. [Table: see text]

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Effect of malnutrition on mortality with new espen criteria in patients with hematological malignancies

Clinical Nutrition ◽

10.1016/j.clnu.2018.06.1712 ◽

2018 ◽

Vol 37 ◽

pp. S197-S198 ◽

Cited By ~ 1

Author(s):

M. Yilmaz ◽

F.D. Atilla ◽

H. Uluer ◽

F. Sahin ◽

G. Saydam

Keyword(s):

Hematological Malignancies ◽

Espen Criteria

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Malnutrition at Admission Predicts In-Hospital Falls in Hospitalized Older Adults

Nutrients ◽

10.3390/nu12020541 ◽

2020 ◽

Vol 12 (2) ◽

pp. 541 ◽

Cited By ~ 3

Author(s):

Yuria Ishida ◽

Keisuke Maeda ◽

Tomoyuki Nonogaki ◽

Akio Shimizu ◽

Yosuke Yamanaka ◽

...

Keyword(s):

Cox Regression ◽

Hazard Ratio ◽

University Hospital ◽

Rank Test ◽

Kaplan Meier ◽

Disease Information ◽

Comorbidity Index ◽

Hospitalized Older Adults ◽

Espen Criteria ◽

Time Of Admission

Malnutrition leads to poor prognoses, including a predisposition to falls. Few studies have investigated the relationship between malnutrition and falls during hospitalization. This study aimed to determine malnutrition’s association with falls during hospitalization. A retrospective observational study was conducted. Patients aged ≥65 years that were admitted to and discharged from a university hospital between April 2018 and March 2019 were examined. Patients with independent basic activities of daily living were included. Diagnosis of malnutrition was based on the European Society for Clinical Nutrition and Metabolism (ESPEN) criteria at admission. Disease information such as the Charlson Comorbidity Index (CCI) and reasons for hospitalization were reviewed. Kaplan–Meier curve and multivariate Cox regression analyses were performed. Data from 6081 patients (mean age: 74.4 ± 6.1 years; males: 58.1%) were analyzed. The mean CCI was 2.3 ± 2.8 points. Malnutrition was detected in 668 (11.0%) and falls occurred in 55 (0.9%) patients. Malnourished patients experienced a higher fall rate than those without malnutrition (2.4% vs. 0.7%, log-rank test p < 0.001). In multivariate analysis, malnutrition had the highest hazard ratio for falls among covariates (hazard ratio 2.78, 95% confidence interval 1.51–5.00, p = 0.001). In conclusion, malnutrition at the time of admission to hospital predicts in-hospital falls.

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Concordance of the new ESPEN criteria with low phase angle in defining early stages of malnutrition in cardiac surgery

Clinical Nutrition ◽

10.1016/j.clnu.2017.08.007 ◽

2018 ◽

Vol 37 (5) ◽

pp. 1596-1601 ◽

Cited By ~ 4

Author(s):

Donata Ringaitiene ◽

Dalia Gineityte ◽

Vaidas Vicka ◽

Akvile Sabestinaite ◽

Andrius Klimasauskas ◽

...

Keyword(s):

Cardiac Surgery ◽

Phase Angle ◽

Early Stages ◽

Espen Criteria

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Nutritional Status and Bone Microarchitecture in a Cohort of Systemic Sclerosis Patients

Nutrients ◽

10.3390/nu12061632 ◽

2020 ◽

Vol 12 (6) ◽

pp. 1632

Author(s):

Sabrina Paolino ◽

Greta Pacini ◽

Carlotta Schenone ◽

Massimo Patanè ◽

Alberto Sulli ◽

...

Keyword(s):

Systemic Sclerosis ◽

Trabecular Bone Score ◽

Bone Microarchitecture ◽

Autonomic Nerve ◽

Quality Data ◽

Mineral Density ◽

Bone Status ◽

Immune System Activation ◽

Gi Symptoms ◽

Espen Criteria

Systemic sclerosis (SSc) is a connective tissue disease characterized by initial microvascular damage, immune system activation and progressive fibrosis with insufficiency of internal organs. Gastrointestinal (GI) involvement is characterized by atrophy of the smooth muscle and small bowel hypomotility, mainly resulting from an autonomic nerve dysfunction. These modifications significantly affect gut transit and nutrient absorption, thus leading to malnutrition deficit induced by malabsorption. Nutritional deficit induced by malabsorption might also lead to bone alterations. This study aims to evaluate the relationship between malnutrition and bone status. Thirty-six postmenopausal female patients fulfilling the ACR 2013 criteria for SSc underwent dual-energy X-ray absorptiometry scan (DXA) to detect quantitative lumbar spine bone mineral density (BMD) and trabecular bone score (TBS) analysis to detect bone quality. Data from DXA also allow to assess body composition and provide several quantitative parameters, including free fat mass index (FFMI) that identifies the patient with malnutrition (values <15 kg/m2 in women and 17 kg/m2 in men), according to the ESPEN criteria. Body mass index (BMI) was calculated for all SSc patients and every patient completed a diary reporting GI symptoms. Two groups of SSc patients with or without diagnosed malnutrition according to FFMI parameter were identified. Malnourished SSc patients showed significantly lower weight (p = 0.01) and BMI (p = 0.001), as well as lower serum levels of hemoglobin (p = 0.009), albumin (p = 0.002), PTH (p = 0.02) and 25OH-vitamin D (p = 0.008). DXA analysis showed significantly lower lumbar L1-L4 T-score (p = 0.009) and BMD values (p = 0.029) in malnourished SSc patients. Consistently, TBS values were significantly lower in malnourished patients (p = 0.008) and correlated with BMD (at any site) and serum albumin levels (p = 0.02). In addition, FFMI positively correlated with bone parameters as well as with symptoms of intestinal impairment in malnourished SSc patients. Finally, GI symptoms significantly correlated with BMD but not with TBS. This pilot study shows that in malnourished SSc patients (2015 ESPEN criteria: FFMI<15 kg/m2), an altered bone status significantly correlates with GI involvement, in terms of symptoms being mainly due to intestinal involvement together with the presence of selected serum biomarkers of malnutrition.

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