The influence of NK alloreactivity on matched unrelated donor and HLA identical sibling haematopoietic stem cell transplantation

2009 ◽  
Vol 21 (5) ◽  
pp. 531-537 ◽  
Author(s):  
Campbell S Witt
Keyword(s):  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Haematopoietic Stem Cell Transplantation ◽  
Haematopoietic Stem Cell ◽  
Unrelated Donor ◽  
Matched Unrelated Donor

scholarly journals CCR5gene polymorphism affects the risk of GvHD after haematopoietic stem cell transplantation from an unrelated donor

2015 ◽  
Vol 171 (2) ◽  
pp. 285-288 ◽  
Author(s):  
Katarzyna Bogunia-Kubik ◽  
Sylwia Mizia ◽  
Anna Gronkowska ◽  
Jacek Nowak ◽  
Sławomira Kyrcz-Krzemień ◽  
...  
Keyword(s):  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Haematopoietic Stem Cell Transplantation ◽  
Haematopoietic Stem Cell ◽  
Unrelated Donor

scholarly journals Chronic-graft-versus-host-disease-related polymyositis: a 17-months-old child with a rare and late complication of haematopoietic stem cell transplantation.

2020 ◽  
Vol 12 (1) ◽  
pp. e2020002
Author(s):  
Matteo Chinello ◽  
Rita Balter ◽  
Massimiliano De Bortoli ◽  
Virginia Vitale ◽  
Ada Zaccaron ◽  
...  
Keyword(s):  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Graft Versus Host Disease ◽  
Haematopoietic Stem Cell Transplantation ◽  
Haematopoietic Stem Cell ◽  
High Dose ◽  
Unrelated Donor ◽  
Host Disease ◽  
Graft Versus Host

Background: Chronic graft versus host disease (cGVHD) occurs in 20-30% of paediatric patients receiving haemopoietic stem cell transplantation (HSCT). Neuromuscular disorders such as polymyositis are considered a rare and distinctive but non-diagnostic manifestation of cGVHD and, in absence of other characteristic signs and symptoms, biopsy is highly recommended to exclude other causes. Case report: We report a case of a 17-months-old child affected by hemophagocytic lymphohistiocytosis who underwent a matched unrelated donor haematopoietic stem cell transplantation (HSCT). She developed a severe cGVHD-related polymyositis that was successfully treated with high-dose steroid therapy, rituximab and sirolimus. Conclusions: This is the first case of cGVHD-related-polymyositis described in a pediatric patient which was successfully treated with rituximab.

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