scholarly journals Aboriginal people with chronic HCV: The role of community health nurses for improving health-related quality of life

2020 ◽  
Vol 27 (3) ◽  
pp. 250-257
Author(s):  
Amineh Rashidi ◽  
Peter Higgs ◽  
Susan Carruthers
Author(s):  
Akio Miyasaka ◽  
Yuichi Yoshida ◽  
Akiko Suzuki ◽  
Yasuhiro Takikawa

Abstract Purpose Long-term effects on patient health-related quality of life (HRQoL) after direct-acting antiviral (DAA) treatment for hepatitis C virus (HCV) are unknown. We assessed the impact of DAA-mediated HCV clearance on HRQoL from DAA initiation to 1 year after confirmed sustained virological response at 24 weeks post-treatment (SVR24). Methods HRQoL was evaluated using the eight-item Short Form Health Survey (SF-8). Chronic HCV-infected patients were treated for 12 weeks with sofosbuvir-based DAAs. SF-8 was administered at baseline, treatment cessation, SVR24, and 1-year post-SVR24. Results A total of 109 chronic HCV-infected patients were enrolled. The average SF-8 scores were higher than the Japanese national standard values for bodily pain (BP) and mental health at baseline and for general health at 1-year post-SVR24. None of the SF-8 scores differed significantly between baseline and 1-year post-SVR24. Regarding age, sex, liver status, and treatment regimen, the SF-8 scores at 1-year post-SVR24 were affected by only age; individuals aged < 65 years had significantly higher physical component score (PCS), physical functioning, role physical, and BP scores than older individuals. In the multivariable analysis, only age of ≥ 65 years was significantly associated with influencing PCS at 1-year post-SVR24. However, no significant factors were identified for mental component score. Conclusion Upon long-term assessment, although more factors trended higher than national standard values at 1-year post-SVR24 than at baseline, there were no significant changes within factors. As PCS tended to be associated with age, patients aged ≥ 65 years should be carefully monitored for PCS.


2004 ◽  
Vol 114 (4) ◽  
pp. 845-850 ◽  
Author(s):  
Hubert Chen ◽  
Patricia P. Katz ◽  
Mark D. Eisner ◽  
Edward H. Yelin ◽  
Paul D. Blanc

2008 ◽  
Vol 14 (7) ◽  
pp. 977-983 ◽  
Author(s):  
àngela Vidal ◽  
Esther Gómez-Gil ◽  
Miquel Sans ◽  
Maria J. Portella ◽  
Manel Salamero ◽  
...  

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