Serum levels of monocyte chemoattractant protein-1 in periodontal health and disease

Cytokine ◽  
2009 ◽  
Vol 47 (2) ◽  
pp. 77-81 ◽  
Author(s):  
A.R. Pradeep ◽  
Happy Daisy ◽  
Parag Hadge
Keyword(s):  
Serum Levels ◽  
Periodontal Health ◽  
Monocyte Chemoattractant Protein 1 ◽  
Monocyte Chemoattractant ◽  
Monocyte Chemoattractant Protein ◽  
Health And Disease

Monocyte chemoattractant protein-1 serum levels in ovarian cancer patients

1999 ◽  
Vol 35 ◽  
pp. S242
Author(s):  
L. Hefler ◽  
C. Tempfer ◽  
G. Heinze ◽  
S. Leodolter ◽  
G. Sliutz ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cancer Patients ◽  
Serum Levels ◽  
Monocyte Chemoattractant Protein 1 ◽  
Monocyte Chemoattractant ◽  
Monocyte Chemoattractant Protein

Role of monocyte chemoattractant protein-1, stromal derived factor-1 and retinoic acid in pathophysiology of neuropathic pain in rats

2016 ◽  
Vol 27 (4) ◽  
Author(s):  
Enas Ahmed Hamed ◽  
Hanan Sayed Mohamed Farghaly ◽  
Asmaa Fathey Abdel Mola ◽  
Minerva Kamal Fahmi ◽  
Madiha Mohammed Makhlouf ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Retinoic Acid ◽  
Sciatic Nerve ◽  
Pain Treatment ◽  
Serum Levels ◽  
Monocyte Chemoattractant Protein 1 ◽  
Monocyte Chemoattractant ◽  
Monocyte Chemoattractant Protein ◽  
Stromal Cell Derived Factor

AbstractChemokines have been recently recognized to play a role in chronic pain syndromes’ pathophysiology. This study investigated the role of monocyte chemoattractant protein-1 (MCP-1), stromal cell derived factor-1 (SDF-1), and retinoic acid (RA) as targets for the therapeutic approach of neuropathic pain.A chronic constriction injury (CCI) model of neuropathic pain by unilateral ligation of left sciatic nerve was performed in adult female Wistar rats. The effects of doxycycline (Dox, 50 mg/kg/day i.p. for 7 days), single dose of bicyclam (5 mg/kg i.p.), RA (15 mg/kg/day i.p. for 7 days), and their combination(s) on behavioral tests of nociception (Von Frey filaments; paw pressure test) on days 0, 1, 3, 5, and 7 of operation were studied. Serum concentrations of MCP-1 and SDF-1 were measured by ELISA. Histological examination of the sciatic nerve was investigated.CCI of sciatic nerve significantly induced mechanical allodynia and hyperalgesia and an increase of MCP-1 and SDF-1 serum levels. Dox-treated groups (Dox, Dox+bicyclam, Dox+RA, Dox+bicyclam+RA) and bicyclam-treated groups (bicyclam, Dox+bicyclam, bicyclam+RA, Dox+bicyclam+RA) attenuated CCI-induced behavioral and biochemical changes. RA inhibited CCI-induced mechanical hyperalgesia but produced a time-dependent reversal of allodynia. Histological findings showed degenerative changes of sciatic nerve after CCI that were partially recovered in Dox-treated groups.These findings demonstrate an association between serum MCP-1 and SDF-1 concentrations and behavioral manifestations of neuropathic pain. RA administration decreased neuropathic pain (antihyperalgesic effect) but did not cause any improvement in sciatic nerve tissues, either alone or in combination with chemokine antagonists. Thus, chemokines may serve as potential targets for drug development in neuropathic pain treatment.

scholarly journals Monocyte chemoattractant protein-1 serum levels in ovarian cancer patients

1999 ◽  
Vol 81 (5) ◽  
pp. 855-859 ◽  
Author(s):  
L Hefler ◽  
C Tempfer ◽  
G Heinze ◽  
K Mayerhofer ◽  
G Breitenecker ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cancer Patients ◽  
Serum Levels ◽  
Monocyte Chemoattractant Protein 1 ◽  
Monocyte Chemoattractant ◽  
Monocyte Chemoattractant Protein

scholarly journals Serum Monocyte Chemoattractant Protein-1 in Pancreatic Cancer

2011 ◽  
Vol 2011 ◽  
pp. 1-6 ◽  
Author(s):  
Jennifer Sullivan ◽  
Qiaoke Gong ◽  
Terry Hyslop ◽  
Harish Lavu ◽  
Galina Chipitsyna ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Smoking Status ◽  
Recursive Partitioning ◽  
Serum Levels ◽  
Ductal Adenocarcinoma ◽  
Clinicopathological Parameters ◽  
Monocyte Chemoattractant Protein 1 ◽  
Monocyte Chemoattractant ◽  
Monocyte Chemoattractant Protein ◽  
Gender And Age

Background/Aims.Pancreatic ductal adenocarcinoma (PDA) has etiological association with chronic inflammation. Elevated circulating levels of inflammatory mediators, such as monocyte chemoattractant protein-1 (MCP-1), are found in obese individuals. We hypothesized that serum MCP-1 levels are elevated in obese PDA patients.Methods.ELISA was used to analyze MCP-1 serum levels in PDA (n=62) and intraductal papillary mucinous neoplasms (IPMN) (n=27). Recursive partitioning statistical analysis investigated the relationship between log MCP-1 and clinicopathological parameters.Results.Log MCP-1 values were significantly (P<0.05) elevated in patients with BMI ≥ 37.5. In patients with BMI < 37.5, average log MCP-1 values were significantly elevated in PDA patients when compared to IPMN patients. Within the IPMN group, higher log MCP-1 levels correlated with increased age. Recursive partitioning analysis of IPMN versus PDA revealed a strategy of predicting characteristics of patients who are more likely to have cancer. This strategy utilizes log MCP-1 as the primary factor and also utilizes smoking status, gender, and age.Conclusion.MCP-1 is a promising biomarker in pancreatic cancer. The potential of using MCP-1 to distinguish PDA from IPMN patients must be studied in larger populations to validate and demonstrate its eventual clinical utility.

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