Interleukin-10 promoter polymorphisms and asthma risk: A meta-analysis

Introduction: Diabetic nephropathy (DN) is a leading cause of chronic kidney disease (CKD) in diabetes patients. There is ample evidence that the inflammatory pathways are central to both diabetes and DN. Several studies that examined the link between the interleukin-10 (IL10) polymorphisms and DN risk yielded conflicting results. Objectives: The purpose of this meta-analysis is to evaluate the associations between IL10 promoter polymorphisms and DN risk. Methods: A bibliographic search was carried out on PubMed, Google scholar and Web of Science from the beginning until July 30, 2020. Association between IL10 promoter variants (-1082 A>G, -819 C>T and -592 C>A) and DN risk were assessed by considering diabetes without nephropathy (DWN) as well as healthy controls. Data were retrieved and the pooled odds ratio (OR) with 95% confidence interval (CI) was calculated. Results: For the IL10 -1082 A> G analysis, a total of 4 studies with DWN controls (682 cases and 529 controls) and 5 studies with healthy controls (1025 cases and 1625 controls) were considered. For the IL10 -819 C> T analysis, a total of three studies with DWN controls (9619 cases and 445 controls) and 5 studies with healthy controls (1005 cases and 1537 controls) were considered. For the IL10 -592 C> T analysis, a total of 5 studies with DWN controls (819 cases and 645 controls) and 5 studies with healthy controls (1005 cases and 1537 controls) were considered. In addition, there was no evidence of publication bias for IL10 promoter variants. No substantial association was observed between IL10 promoter variants and DN risk. Conclusion: Our study signifies that polymorphisms of IL10 -1082 A>G, -819 C>T and -592 C>A are not linked with DN risk.

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Association of three promoter polymorphisms in interleukin-10 gene with cancer susceptibility in the Chinese population: a meta-analysis

Oncotarget ◽

10.18632/oncotarget.18220 ◽

2017 ◽

Vol 8 (37) ◽

pp. 62382-62399 ◽

Cited By ~ 2

Author(s):

Ping Wang ◽

Junling An ◽

Yanfeng Zhu ◽

Xuedong Wan ◽

Hongzhen Zhang ◽

...

Keyword(s):

Chinese Population ◽

Cancer Susceptibility ◽

Meta Analysis ◽

Interleukin 10 ◽

Promoter Polymorphisms

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Association of interleukin-10 gene promoter polymorphisms with recurrent miscarriage: a meta-analysis

American Journal of Reproductive Immunology ◽

10.1111/aji.12531 ◽

2016 ◽

Vol 76 (2) ◽

pp. 172-180 ◽

Cited By ~ 3

Author(s):

Duo Su ◽

Yeye Zhang ◽

Qingqin Wang ◽

Jing Wang ◽

Baoquan Jiao ◽

...

Keyword(s):

Recurrent Miscarriage ◽

Meta Analysis ◽

Gene Promoter ◽

Interleukin 10 ◽

Promoter Polymorphisms

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The association of three promoter polymorphisms in interleukin-10 gene with the risk for colorectal cancer and hepatocellular carcinoma: A meta-analysis

Scientific Reports ◽

10.1038/srep30809 ◽

2016 ◽

Vol 6 (1) ◽

Cited By ~ 1

Author(s):

Yan-Hui Shi ◽

Dong-Mei Zhao ◽

Yue-Fei Wang ◽

Xue Li ◽

Man-Ru Ji ◽

...

Keyword(s):

Colorectal Cancer ◽

Hepatocellular Carcinoma ◽

Meta Analysis ◽

Interleukin 10 ◽

Promoter Polymorphisms

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Interleukin-18 Polymorphisms Deficiency Association with Asthma Risk: An Update Meta-analysis

Iranian Journal of Allergy Asthma and Immunology ◽

10.18502/ijaai.v18i3.1118 ◽

2019 ◽

Author(s):

Huan LIU ◽

Yu Feng ◽

Wei Zhang ◽

Xiao-Dong Deng ◽

Ying Ma ◽

...

Keyword(s):

Publication Bias ◽

Meta Analysis ◽

Interleukin 18 ◽

Promoter Polymorphisms ◽

Random Effects Models ◽

Asthma Risk ◽

Genotype Frequencies ◽

Fixed And Random Effects ◽

Matching Criteria ◽

Strength Of Association

Growing evidence indicated conflicting results that Interleukin-18 (IL-18) promoter polymorphisms rs1946518 (A-607C), rs187238 (G-137C) and rs549908 (A-105C) were associated with asthma risk. The aim of this study is to comprehensively evaluate the IL-18 polymorphisms and asthma by a systematic review and meta-analysis. A total of 12 studies testing the association between these polymorphisms and asthma were examined (8 studies for A-607C, 8 studies for G-137C, and 4 studies for A-105C) in the update meta-analysis, up to Dec 30, 2017. Summary odds ratios (ORs) and 95% confidence intervals (CI) were used to estimate the strength of association between each polymorphism and asthma using fixed- and random-effects models when appropriate. Heterogeneity and publication bias were evaluated. The meta-analysis results indicated that any allele frequencies of the IL-18 polymorphisms (A-607C, G-137C and A-105C) was not associated with asthma risk (p>0.05). And no statistically significant association was observed between genotype frequencies of these polymorphisms and asthma under different genetic models (p>0.05). Subgroup analysis results were similar to the main analysis by ethnicity, sample size, genotyping methods, matching criteria and quality score. There was no evidence of publication bias. The present meta-analysis suggests that IL-18 polymorphisms (A-607C, G-137C and A-105C) were unlikely to be associated with asthma risk.

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