scholarly journals Telomere length: A possible link between phthalate exposure and cancer development?

EBioMedicine ◽  
2016 ◽  
Vol 6 ◽  
pp. 6-7 ◽  
Author(s):  
Qiuyin Cai
Keyword(s):  
Telomere Length ◽  
Cancer Development ◽  
Phthalate Exposure

scholarly journals Telomeres and Cancer

Life ◽  
2021 ◽  
Vol 11 (12) ◽  
pp. 1405
Author(s):  
Hueng-Chuen Fan ◽  
Fung-Wei Chang ◽  
Jeng-Dau Tsai ◽  
Kao-Min Lin ◽  
Chuan-Mu Chen ◽  
...  
Keyword(s):  
Telomere Length ◽  
Molecular Mechanisms ◽  
Telomere Maintenance ◽  
Cancer Development ◽  
Telomere Elongation ◽  
Metabolism Pathway ◽  
Length Regulation ◽  
Telomere Length Regulation ◽  
Genome Protection

Telomeres cap the ends of eukaryotic chromosomes and are indispensable chromatin structures for genome protection and replication. Telomere length maintenance has been attributed to several functional modulators, including telomerase, the shelterin complex, and the CST complex, synergizing with DNA replication, repair, and the RNA metabolism pathway components. As dysfunctional telomere maintenance and telomerase activation are associated with several human diseases, including cancer, the molecular mechanisms behind telomere length regulation and protection need particular emphasis. Cancer cells exhibit telomerase activation, enabling replicative immortality. Telomerase reverse transcriptase (TERT) activation is involved in cancer development through diverse activities other than mediating telomere elongation. This review describes the telomere functions, the role of functional modulators, the implications in cancer development, and the future therapeutic opportunities.

scholarly journals Short Telomere Length as a Biomarker Risk of Lung Cancer Development Induced by High Radon Levels: A Pilot Study

2018 ◽  
Vol 15 (10) ◽  
pp. 2152 ◽  
Author(s):  
Narongchai Autsavapromporn ◽  
Pitchayaponne Klunklin ◽  
Chalat Threeratana ◽  
Wirote Tuntiwechapikul ◽  
Masahiro Hosoda ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Telomere Length ◽  
Cancer Patients ◽  
Indoor Radon ◽  
Cancer Development ◽  
Chiang Mai ◽  
Lung Cancer Patients ◽  
Average Value ◽  
Depth Study ◽  
One Year

Long-term exposure to radon has been determined to be the second leading cause of lung cancer after tobacco smoking. However, an in-depth study of this topic has not been explicitly carried out in Chiang Mai (Thailand). This paper presents the results of an indoor radon level measurement campaign in dwellings of Chiang Mai using total of 110 detectors (CR-39) during one year. The results show that the average radon levels varied from 35 to 219 Bq/m3, with an overall average of 57 Bq/m3. The finding also shows that the average value is higher than the global average value of 39 Bq/m3. In addition, to examine the cause of lung cancer development among people with risk of chronic exposure to radon during their lifetime, 35 non-smoker lung cancer patients and 33 healthy nonsmokers were analyzed for telomere length. As expected, telomere length was significantly shorter in lung cancer patients than in healthy nonsmokers. Among healthy nonsmokers, the telomere length was significantly shorter in a high radon group than in an unaffected low radon group. To the best of our knowledge, our research provides the first attempt in describing the shortened telomeres in areas with high levels of environmental radon that might be related to lung cancer development.

scholarly journals Blood Telomere Length Attrition and Cancer Development in the Normative Aging Study Cohort

EBioMedicine ◽  
2015 ◽  
Vol 2 (6) ◽  
pp. 591-596 ◽  
Author(s):  
Lifang Hou ◽  
Brian Thomas Joyce ◽  
Tao Gao ◽  
Lei Liu ◽  
Yinan Zheng ◽  
...  
Keyword(s):  
Telomere Length ◽  
Cancer Development ◽  
Study Cohort ◽  
Normative Aging Study ◽  
Aging Study ◽  
Normative Aging

scholarly journals Prenatal phthalate exposure and placental telomere length

2022 ◽  
Vol 226 (1) ◽  
pp. S559
Author(s):  
Rebecca J. Mahn ◽  
Sara G. Brubaker ◽  
Shilpi S. Mehta-Lee ◽  
David L. Keefe
Keyword(s):  
Telomere Length ◽  
Phthalate Exposure

Increased serum MMP-2, MMP-7, MMP-9, TIMP-1 and TIMP-2 levels in colorectal cancer development

2011 ◽  
Vol 49 (05) ◽  
Author(s):  
I Hritz ◽  
Z Varga ◽  
M Juhász ◽  
P Miheller ◽  
Z Tulassay ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Development

Relationship between telomere length and dyslipidemia in patients with Cushing's syndrome

2013 ◽  
Author(s):  
Anna Aulinas ◽  
Ramirez Maria Jose ◽  
Barahona Maria Jose ◽  
Eugenia Mato ◽  
Olga Bell ◽  
...  
Keyword(s):  
Telomere Length ◽  
Cushing’S Syndrome ◽  
Cushing's Syndrome

Metaplasia — A Transdifferentiatlon Process that Facilitates Cancer Development: The Model of Gastric Intestinal Metaplasia

2006 ◽  
Vol 12 (1-2) ◽  
pp. 3-26 ◽  
Author(s):  
Patricia Mesquita ◽  
Raquel Almeida ◽  
Nuno Lunet ◽  
Celso A. Reis ◽  
Luis Filipe Santos Silva ◽  
...  
Keyword(s):  
Intestinal Metaplasia ◽  
Cancer Development ◽  
Gastric Intestinal Metaplasia
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