Melatonin inhibits prostaglandin E2- and sodium nitroprusside-induced ion secretion in rat distal colon

2008 ◽  
Vol 581 (1-2) ◽  
pp. 164-170 ◽  
Author(s):  
Libor Mrnka ◽  
Miroslav Hock ◽  
Markéta Rybová ◽  
Jiří Pácha
Keyword(s):  
Prostaglandin E2 ◽  
Sodium Nitroprusside ◽  
Distal Colon ◽  
Ion Secretion ◽  
Rat Distal Colon

Somatostatin receptor subtype 2 mediates somatostatin inhibition of ion secretion in rat distal colon

1996 ◽  
Vol 111 (2) ◽  
pp. 325-333 ◽  
Author(s):  
G Warhurst ◽  
NB Higgs ◽  
H Fakhoury ◽  
AC Warhurst ◽  
J Garde ◽  
...  
Keyword(s):  
Somatostatin Receptor ◽  
Distal Colon ◽  
Receptor Subtype ◽  
Ion Secretion ◽  
Rat Distal Colon ◽  
Somatostatin Receptor Subtype 2

Histamine-induced ion secretion across rat distal colon: Involvement of histamine H1 and H2 receptors

2006 ◽  
Vol 546 (1-3) ◽  
pp. 161-170 ◽  
Author(s):  
Gerhard Schultheiss ◽  
Britta Hennig ◽  
Walter Schunack ◽  
Gundula Prinz ◽  
Martin Diener
Keyword(s):  
Distal Colon ◽  
Ion Secretion ◽  
H2 Receptors ◽  
Rat Distal Colon

Adenosine A3 receptor expression in peplidergic neural circuits of the rat distal colon

2001 ◽  
Vol 120 (5) ◽  
pp. A177-A177
Author(s):  
S SHARP ◽  
J YU ◽  
J GUZMAN ◽  
J XUE ◽  
H COOKE ◽  
...  
Keyword(s):  
Neural Circuits ◽  
Distal Colon ◽  
Receptor Expression ◽  
Adenosine A3 Receptor ◽  
Rat Distal Colon

Fibre-free diet leads to impairment of neuronally mediated muscle contractile response in rat distal colon

2006 ◽  
Vol 18 (12) ◽  
pp. 1093-1101 ◽  
Author(s):  
r. mitsui ◽  
s.-i. karaki ◽  
y. kubo ◽  
y. sugiura ◽  
a. kuwahara
Keyword(s):  
Contractile Response ◽  
Distal Colon ◽  
Rat Distal Colon ◽  
Muscle Contractile

Dietary fish oils decrease bradykinin-induced secretion in rat distal colon

1997 ◽  
Vol 17 (4) ◽  
pp. 693-702 ◽  
Author(s):  
Kumiko Yamazaki ◽  
Takaji Yajima ◽  
Tamotsu Kuwata
Keyword(s):  
Distal Colon ◽  
Fish Oils ◽  
Rat Distal Colon ◽  
Dietary Fish

Bicarbonate secretion in rat distal colon in vitro: a measurement technique

1988 ◽  
Vol 254 (3) ◽  
pp. C383-C390 ◽  
Author(s):  
G. M. Feldman ◽  
S. F. Berman ◽  
R. L. Stephenson
Keyword(s):  
Short Circuit ◽  
Distal Colon ◽  
Apparent Permeability ◽  
Chemical Gradients ◽  
Acid Generation ◽  
Rat Distal Colon ◽  
Tissue Surfaces ◽  
Apparent Permeability Coefficient ◽  
Transepithelial Voltage

To study HCO3- secretion in rat distal colon, we utilized a technique that permits control of electrical and chemical transepithelial gradients. With symmetrical solutions (pH 7.4, [HCO3-] 25 mM, and CO2 tension 40 mmHg) bathing both tissue surfaces and under short-circuit conditions, HCO3- secretion remained stable for greater than 4 h at 1 mueq. h-1.cm-2. As the mucosal solution was alkalinized, the serosal solution was acidified at 3.1 mueq.h-1.cm-2. Ninety-four percent of serosal acidification was accounted for by the rate of metabolic lactic acid generation and transepithelial HCO3- secretion. Clamping transepithelial voltage reversibly affected net HCO3- secretion, and a linear relationship existed between clamped mucosal voltage and net HCO3- flux (r = 0.99); mucosal voltage of -68 mV completely inhibited net secretion. The apparent permeability coefficient of the colon to HCO3- is 2.8 X 10(-6) cm/s. One millimolar ouabain completely inhibited net HCO3- secretion. Acetazolamide (10(-4) M) inhibited secretion by approximately 50%, whereas a 10(-3) M concentration inhibited secretion by 90%. These data demonstrate that net colonic HCO3- secretion can be measured without imposed electrical and chemical gradients and that this flux is voltage sensitive and depends on carbonic anhydrase and Na+-K+-ATPase activities.

scholarly journals Diverting colostomy induces mucosal and muscular atrophy in rat distal colon.

Gut ◽  
1994 ◽  
Vol 35 (9) ◽  
pp. 1275-1281 ◽  
Author(s):  
P Kissmeyer-Nielsen ◽  
H Christensen ◽  
S Laurberg
Keyword(s):  
Muscular Atrophy ◽  
Distal Colon ◽  
Rat Distal Colon ◽  
Diverting Colostomy
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