The emerging role of transport systems in liver function tests

2012 ◽  
Vol 675 (1-3) ◽  
pp. 1-5 ◽  
Author(s):  
Bruno Stieger ◽  
Michal Heger ◽  
Wilmar de Graaf ◽  
Gustav Paumgartner ◽  
Thomas van Gulik
Keyword(s):  
Liver Function ◽  
Liver Function Tests ◽  
Transport Systems ◽  
Function Tests

scholarly journals Safety and Yield of Diagnostic ERCP in Liver Transplant Patients with Abnormal Liver Function Tests

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
Jayapal Ramesh ◽  
Nipun Reddy ◽  
Hwasoon Kim ◽  
Klaus Mönkemüller ◽  
Shyam Varadarajulu ◽  
...  
Keyword(s):  
Liver Function ◽  
Liver Transplant ◽  
Liver Function Tests ◽  
Abnormal Liver Function ◽  
Biliary Stones ◽  
Organ Rejection ◽  
Transplant Patients ◽  
Function Tests ◽  
Biliary Pathology

Background. Abnormal liver enzymes postorthotopic liver transplant (OLT) may indicate significant biliary pathology or organ rejection. There is very little known in the literature regarding the current role of diagnostic ERCP in this scenario. Aim. To review the utility of diagnostic ERCP in patients presenting with abnormal liver function tests in the setting of OLT. Methods. A retrospective review of diagnostic ERCPs in patients with OLT from 2002 to 2013 from a prospectively maintained, IRB approved database. Results. Of the 474 ERCPs performed in OLT patients, 210 (44.3%; 95% CI 39.8–48.8) were performed for abnormal liver function tests during the study period. Majority of patients were Caucasian (83.8%), male (62.4%) with median age of 55 years (IQR 48–62 years). Biliary cannulation was successful in 99.6% of cases and findings included stricture in 45 (21.4 %); biliary stones/sludge in 23 (11%); biliary dilation alone in 31 (14.8%); and normal in 91 (43.3%). Three (1.4%) patients developed mild, self-limiting pancreatitis; one patient (0.5%) developed cholangitis and two (1%) had postsphincterotomy bleeding. Multivariate analyses showed significant association between dilated ducts on imaging with a therapeutic outcome. Conclusion. Diagnostic ERCP in OLT patients presenting with liver function test abnormalities is safe and frequently therapeutic.

Cohort Multicenter Study on the Role of Medications in Parenteral Nutrition–Related Alteration of Liver Function Tests in Adults

2020 ◽  
Author(s):  
Javier Mateu‐de Antonio ◽  
María Teresa Miana‐Mena ◽  
Eva Martínez‐Bernabé ◽  
Juan González‐Valdivieso ◽  
David Berlana ◽  
...  
Keyword(s):  
Liver Function ◽  
Parenteral Nutrition ◽  
Multicenter Study ◽  
Liver Function Tests ◽  
Function Tests

Role of Liver Function Tests in Monitoring Anticonvulsant Use

CNS Drugs ◽  
1998 ◽  
Vol 10 (5) ◽  
pp. 321-328 ◽  
Author(s):  
Dieter Schmidt ◽  
Hartmut Siemes
Keyword(s):  
Liver Function ◽  
Liver Function Tests ◽  
Function Tests

scholarly journals Role of Liver Function Tests in Detecting Methotrexate-Induced Liver Damage in Sarcoidosis

2003 ◽  
Vol 163 (5) ◽  
pp. 615 ◽  
Author(s):  
Robert P. Baughman ◽  
Allison Koehler ◽  
Pablo A. Bejarano ◽  
Elyse E. Lower ◽  
Fredrick L. Weber
Keyword(s):  
Liver Function ◽  
Liver Damage ◽  
Liver Function Tests ◽  
Function Tests

scholarly journals Role of the Standard ‘Liver Function Tests’ in Current Clinical Practice

1989 ◽  
Vol 26 (6) ◽  
pp. 463-471 ◽  
Author(s):  
P J Johnson
Keyword(s):  
Liver Function ◽  
Liver Diseases ◽  
Liver Function Tests ◽  
Current Therapy ◽  
Main Role ◽  
Non Invasive ◽  
Function Tests ◽  
Precise Diagnosis ◽  
Near Future

A prerequisite of current therapy in liver disease is precise diagnosis. The rapid increase in the number of tests available—immunological, virological, histological and radiological—testifies to this, and reflects the inadequacy of the ‘standard’ liver function tests (LFTs). The LFTs are, however, in contrast to these more sophisticated tests, observer independent and despite their lack of specificity, several characteristic patterns of abnormality can be recognised which direct the physician to the most appropriate definitive investigation. The cheapness and non-invasive nature of the LFTs makes them particularly appropriate for monitoring the course of liver diseases once the diagnosis has been established and this, together with screening for hepatotoxicity of newly developed drugs, is now their main role. A second generation of liver function tests based on the capacity of the liver to eliminate various test compounds may come closer to offering a true estimate of liver function. More accurate methods of measuring the various bilirubin fractions, particularly bilirubin conjugates may also become available in the near future and provide more sensitive tests of liver dysfunction.

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