Andrographolide protects against isoproterenol-induced myocardial infarction in rats through inhibition of L-type Ca2+ and increase of cardiac transient outward K+ currents

2021 ◽  
pp. 174194
Author(s):  
Seyi Elijah Elasoru ◽  
Paula Rhana ◽  
Tatiane de Oliveira Barreto ◽  
Dayane Lorena Naves de Souza ◽  
José Evaldo Rodrigues de Menezes-Filho ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
K Currents

scholarly journals AKAP150 participates in calcineurin/NFAT activation during the down-regulation of voltage-gated K+ currents in ventricular myocytes following myocardial infarction

2016 ◽  
Vol 28 (7) ◽  
pp. 733-740 ◽  
Author(s):  
Madeline Nieves-Cintrón ◽  
Dinesh Hirenallur-Shanthappa ◽  
Patrick J. Nygren ◽  
Simon A. Hinke ◽  
Mark L. Dell'Acqua ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Ventricular Myocytes ◽  
Down Regulation ◽  
Voltage Gated ◽  
Nfat Activation ◽  
K Currents

scholarly journals NFATc3-Induced Reductions in Voltage-Gated K + Currents After Myocardial Infarction

2004 ◽  
Vol 94 (10) ◽  
pp. 1340-1350 ◽  
Author(s):  
Charles F. Rossow ◽  
Elina Minami ◽  
Eric G. Chase ◽  
Charles E. Murry ◽  
L.F. Santana
Keyword(s):  
Myocardial Infarction ◽  
Voltage Gated ◽  
K Currents

Myocardial infarction in rat eliminates regional heterogeneity of AP profiles, I to K+currents, and [Ca2+]i transients

2002 ◽  
Vol 283 (3) ◽  
pp. H1157-H1168 ◽  
Author(s):  
Roger Kaprielian ◽  
Rajan Sah ◽  
Tin Nguyen ◽  
Alan D. Wickenden ◽  
Peter H. Backx
Keyword(s):  
Myocardial Infarction ◽  
Regional Differences ◽  
Ventricular Myocytes ◽  
Interventricular Septum ◽  
Free Wall ◽  
Right Ventricular Free Wall ◽  
Regional Heterogeneity ◽  
Intracellular Ca ◽  
The Right ◽  
K Currents

Transient outward K+ current density ( I to) has been shown to vary between different regions of the normal myocardium and to be reduced in heart disease. In this study, we measured regional changes in action potential duration (APD), I to, and intracellular Ca2+ concentration ([Ca2+]i) transients of ventricular myocytes derived from the right ventricular free wall (RVW) and interventricular septum (SEP) 8 wk after myocardial infarction (MI). At +40 mV, I to density in sham-operated hearts was significantly higher ( P < 0.01) in the RVW (15.0 ± 0.8 pA/pF, n = 47) compared with the SEP (7.0 ± 1.1 pA/pF, n = 18). After MI, I to density was not reduced in SEP myocytes but was reduced ( P < 0.01) in RVW myocytes (8.7 ± 1.0 pA/pF, n = 26) to levels indistinguishable from post-MI SEP myocytes. These changes in I to density correlated with Kv4.2 (but not Kv4.3) protein expression. By contrast, Kv1.4 expression was significantly higher in the RVW compared with the SEP and increased significantly after MI in RVW. APD measured at 50% or 90% repolarization was prolonged, whereas peak [Ca2+]i transients amplitude was higher in the SEP compared with the RVW in sham myocytes. These regional differences in APD and [Ca2+]i transients were eliminated by MI. Our results demonstrate that the significant regional differences in I to density, APD, and [Ca2+]i between RVW and SEP are linked to a variation in Kv4.2 expression, which largely disappears after MI.

An electron microscopic study of the intra-myocardial lesions in cases of acute myocardial infarction

1978 ◽  
Vol 36 (2) ◽  
pp. 484-485
Author(s):  
Masahiro Ono ◽  
Kaoru Aihara ◽  
Gompachi Yajima
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Coronary Vessels ◽  
Vascular Wall ◽  
Vascular Changes ◽  
Electron Microscopic ◽  
Main Trunk ◽  
Mechanical Destruction ◽  
Transmission Electron ◽  
Myocardial Lesions

The pathogenesis of the arteriosclerosis in the acute myocardial infarction is the matter of the extensive survey with the transmission electron microscopy in experimental and clinical materials. In the previous communication,the authors have clarified that the two types of the coronary vascular changes could exist. The first category is the case in which we had failed to observe no occlusive changes of the coronary vessels which eventually form the myocardial infarction. The next category is the case in which occlusive -thrombotic changes are observed in which the myocardial infarction will be taken placed as the final event. The authors incline to designate the former category as the non-occlusive-non thrombotic lesions. The most important findings in both cases are the “mechanical destruction of the vascular wall and imbibition of the serous component” which are most frequently observed at the proximal portion of the coronary main trunk.

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