Inferior mesenteric artery lymph node metastasis in rectal cancer treated with neoadjuvant chemoradiotherapy: Incidence, prediction and prognostic impact

2017 ◽  
Vol 43 (1) ◽  
pp. 85-91 ◽  
Author(s):  
Y. Sun ◽  
P. Chi ◽  
H. Lin ◽  
X. Lu ◽  
Y. Huang ◽  
...  
2010 ◽  
Vol 18 (3) ◽  
pp. 704-710 ◽  
Author(s):  
Jeonghyun Kang ◽  
Hyuk Hur ◽  
Byung Soh Min ◽  
Nam Kyu Kim ◽  
Kang Young Lee

2021 ◽  
Vol 8 ◽  
Author(s):  
Bin Chen ◽  
Xing Liu ◽  
Yiyi Zhang ◽  
Jinfu Zhuang ◽  
Yong Peng ◽  
...  

Background: The objective of this study is to assess the prognostic value of lymph node metastasis distribution (LND) in locally advanced rectal cancer (LARC) after neoadjuvant chemoradiotherapy (nCRT).Methods: This study included 179 patients with pathological stage III LARC who underwent nCRT followed by radical surgery. LND was classified into three groups: LND1, lymph node metastasis at the mesorectum (140/179, 78.2%); LND2, lymph node metastasis along the inferior mesenteric artery trunk nodes (26/179, 14.5%); LND3, lymph node metastasis at the origin of the IMA (13/179, 7.3%). Clinicopathologic characteristics were analyzed to identify independent prognostic factors.Result: LND showed better stratification for 3-year DFS (LND1 66.8, LND2 50, and LND3 15.4%, P < 0.01) compared to the ypN (3-year DFS: N1 59.9 and N2 60.3%, P = 0.34) and ypTNM (3-year DFS: IIIA 68.6%, IIIB 57.5%, and IIIC 53.5, P = 0.19) staging systems. Similar results were found for 3-year LRFS and DMFS. According to multivariate survival analysis, LND was shown to be an independent prognostic factor for DFS, LRFS, and DMFS in patients with positive lymph nodes (P < 0.01, in all cases).Conclusion: LND is an independent prognostic factor in stage III rectal cancer after nCRT. LND can be used as a supplementary indicator for the ypTNM staging system in patients with LARC after nCRT.


2011 ◽  
Vol 17 (1) ◽  
pp. 63-68 ◽  
Author(s):  
Hiroshi Kitamura ◽  
Fumiyasu Takei ◽  
Sachiyo Nishida ◽  
Takashi Muranaka ◽  
Naoya Masumori ◽  
...  

2005 ◽  
Vol 40 (7) ◽  
pp. 858-861 ◽  
Author(s):  
Yutaka J. Kawamura ◽  
Masako Sakuragi ◽  
Kazutomo Togashi ◽  
Masaki Okada ◽  
Hideo Nagai ◽  
...  

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