Reply to the comment to our article titled: “Association of metabolic syndrome with low birth weight of birth, intake hypercaloric diets and acanthosis nigricans in childhood and teens with overweight and obesity”

2017 ◽  
Vol 64 (10) ◽  
pp. 568-569
Author(s):  
Marlen Velazquez-Bautista ◽  
Joana Jazmín López-Sandoval ◽  
Mercedes González-Hita ◽  
Eduardo Vázquez-Valls ◽  
Iris Z. Cabrera-Valencia ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Acanthosis Nigricans ◽  
Overweight And Obesity

Association of metabolic syndrome with low birth weight, intake of high-calorie diets and acanthosis nigricans in children and adolescents with overweight and obesity

2017 ◽  
Vol 64 (1) ◽  
pp. 11-17 ◽  
Author(s):  
Marlen Velazquez-Bautista ◽  
Joana Jazmín López-Sandoval ◽  
Mercedes González-Hita ◽  
Eduardo Vázquez-Valls ◽  
Iris Zamihara Cabrera-Valencia ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Children And Adolescents ◽  
Acanthosis Nigricans ◽  
Overweight And Obesity ◽  
High Calorie

scholarly journals Metabolic Syndrome in Italian Obese Children and Adolescents: Stronger Association with Central Fat Depot than with Insulin Sensitivity and Birth Weight

2011 ◽  
Vol 2011 ◽  
pp. 1-6 ◽  
Author(s):  
Claudia Brufani ◽  
Danilo Fintini ◽  
Ugo Giordano ◽  
Alberto Enrico Tozzi ◽  
Fabrizio Barbetti ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Birth Weight ◽  
Insulin Sensitivity ◽  
Low Birth Weight ◽  
Children And Adolescents ◽  
Central Obesity ◽  
Obese Children ◽  
Obesity Index ◽  
Central Fat ◽  
Fat Depot

Aim. To evaluate whether body fat distribution, birth weight, and family history for diabetes (FHD) were associated with metabolic syndrome (MetS) in children and adolescents.Methods. A total of 439 Italian obese children and adolescents (5–18 years) were enrolled. Subjects were divided into 2 groups: prepubertal and pubertal. MetS was diagnosed according to the adapted National Cholesterol Education Program criteria. Birth weight percentile, central obesity index (measured by dual-energy X-ray absorptiometry), insulin sensitivity (ISI), and disposition index were evaluated. Multivariate logistic regression models were used to determine variables associated with MetS.Results. The prevalence of MetS was 17%, with higher percentage in adolescents than in children (21 versus 12%). In the overall population, central obesity index was a stronger predictor of MetS than insulin sensitivity and low birth weight. When the two groups were considered, central fat depot remained the strongest predictor of MetS, with ISI similarly influencing the probability of MetS in the two groups and birth weight being negatively associated to MetS only in pubertal individuals. Neither FHD nor degree of fatness was a significant predictor of MetS.Conclusion. Simple clinical parameters like increased abdominal adiposity and low birth weight could be useful tools to identify European obese adolescents at risk for metabolic complications.

scholarly journals Born with low birth weight in rural Southern India: what are the metabolic consequences 20 years later?

2012 ◽  
Vol 166 (4) ◽  
pp. 647-655 ◽  
Author(s):  
Nihal Thomas ◽  
Louise G Grunnet ◽  
Pernille Poulsen ◽  
Solomon Christopher ◽  
Rachaproleu Spurgeon ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Glucose Tolerance ◽  
Indian Population ◽  
Oral Glucose ◽  
Predisposing Factor ◽  
Normal Birth ◽  
The Metabolic Syndrome

ObjectiveLow birth weight (LBW) is common in the Indian population and may represent an important predisposing factor for type 2 diabetes (T2D) and the metabolic syndrome. Intensive metabolic examinations in ethnic LBW Asian Indians have been almost exclusively performed in immigrants living outside India. Therefore, we aimed to study the metabolic impact of being born with LBW in a rural non-migrant Indian population.Subjects and methodsOne hundred and seventeen non-migrant, young healthy men were recruited from a birth cohort in a rural part of south India. The subjects comprised 61 LBW and 56 normal birth weight (NBW) men, with NBW men acting as controls. Subjects underwent a hyperinsulinaemic euglycaemic clamp, i.v. and oral glucose tolerance tests and a dual-energy X-ray absorptiometry scan. The parents' anthropometric status and metabolic parameters were assessed.ResultsMen with LBW were shorter (167±6.4 vs 172±6.0 cm,P<0.0001), lighter (51.9±9 vs 55.4±7 kg,P=0.02) and had a reduced lean body mass (42.1±5.4 vs 45.0±4.5 kg,P=0.002) compared with NBW controls. After adjustment for height and weight, the LBW subjects had increased diastolic blood pressure (77±6 vs 75±6 mmHg,P=0.01). Five LBW subjects had impaired glucose tolerance.In vivoinsulin secretion and peripheral insulin action were similar in both the groups. Mothers of the LBW subjects were 3 cm shorter than the control mothers.ConclusionOnly subtle features of the metabolic syndrome and changes in body composition among LBW rural Indians were found. Whether other factors such as urbanisation and ageing may unmask more severe metabolic abnormalities may require a long-term follow-up.

Obesity, hormonal and metabolic abnormalities in adolescent girls with polycystic ovary syndrome

2013 ◽  
Vol 154 (31) ◽  
pp. 1226-1234
Author(s):  
László Ságodi ◽  
Béla Lombay ◽  
Ildikó Vámosi ◽  
László Barkai
Keyword(s):  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Body Mass Index ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Polycystic Ovary Syndrome ◽  
Adolescent Girls ◽  
Polycystic Ovary ◽  
Metabolic Abnormalities ◽  
Ovary Syndrome

Introduction: Polycystic ovary syndrome is associated with metabolic abnormalities, such as dyslipidemia, obesity, glucose intolerance, which are also components of the metabolic syndrome. Central obesity and insulin resistance appear to play an important role in the pathogenesis of polycystic ovary syndrome, perhaps via subsequent steroidogenic dysregulation. Aim: The aim of the authors was to assess metabolic and hormonal abnormalities in adolescent girls with polycystic ovary syndrome. Method: The study included 52 adolescents diagnosed with polycystic ovary syndrome based on the Rotterdam criteria. Anthropometric, hormonal and metabolic parameters were evaluated among all subjects. 20 healthy, age-matched, non-obese, regularly menstruating girls were used as controls. Of the 52 patients, 15 patients were born with low-birth-weight and 37 patients were born with normal birth weight. Oral glucose tolerance test was performed in all patients and controls. The age of patients was 16.8±3.1 years, and the age of controls was 16.95±2.1 years. Results: Among patients with polycystic ovary syndrome the prevalence of overweight and obesity was 35% (n = 18), while impaired fasting glucose occurred in one patient, impaired glucose tolerance in 8 patients, insulin resistance in 25 patients and metabolic syndrome in 12 patients. Serum triglyceride levels in patients and controls were 1.4±0.8 and 0.9±0.3 mmol/l, respectively (p<0.05), while fasting blood glucose, total cholesterol, HDL and LDL cholesterol were not different in the two groups. Metabolic abnormalities and obesity were more severe and more frequent in patients with low-birth-weight compared to those born with normal weight. There was a negative correlation between birth weight and body mass index SDS values and a positive correlation between fasting insulin levels and body mass index SDS (r = 0.37) in patients born with low-birth-weight. Conclusions: Abnormal glucose metabolism is frequently present in adolescents with polycystic ovary syndrome. It is possible that early diagnosis of polycystic ovary syndrome in adolescences may prevent some of the long-term complications associated with this syndrome. Orv. Hetil., 2013, 154, 1226–1234.

Does Low Birth Weight Predict Obesity/Overweight and Metabolic Syndrome in Elementary School Children?

2008 ◽  
Vol 39 (8) ◽  
pp. 796-802 ◽  
Author(s):  
Valeria Hirschler ◽  
Jimena Bugna ◽  
Maria Roque ◽  
Tomás Gilligan ◽  
Claudio Gonzalez
Keyword(s):  
Metabolic Syndrome ◽  
Elementary School ◽  
Birth Weight ◽  
Low Birth Weight ◽  
School Children ◽  
Elementary School Children

Components of the Metabolic Syndrome in Early Childhood in Very-Low-Birth-Weight Infants

2014 ◽  
Vol 81 (1) ◽  
pp. 43-49 ◽  
Author(s):  
Miranda de Jong ◽  
Harrie N. Lafeber ◽  
Anneke Cranendonk ◽  
Mirjam M. van Weissenbruch
Keyword(s):  
Metabolic Syndrome ◽  
Early Childhood ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Very Low Birth Weight ◽  
Low Birth Weight Infants ◽  
The Metabolic Syndrome

scholarly journals Influence of birth weight on gene regulators of lipid metabolism and utilization in subcutaneous adipose tissue and skeletal muscle of neonatal pigs

Reproduction ◽  
2009 ◽  
Vol 138 (3) ◽  
pp. 609-617 ◽  
Author(s):  
P J Williams ◽  
N Marten ◽  
V Wilson ◽  
J C Litten-Brown ◽  
A M Corson ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Metabolic Syndrome ◽  
Adipose Tissue ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Subcutaneous Adipose Tissue ◽  
Morphological Changes ◽  
Fatty Acid Binding ◽  
Obesity And Diabetes ◽  
Subcutaneous Adipose

Epidemiological studies suggest that low-birth weight infants show poor neonatal growth and increased susceptibility to metabolic syndrome, in particular, obesity and diabetes. Adipose tissue development is regulated by many genes, including members of the peroxisome proliferator-activated receptor (PPAR) and the fatty acid-binding protein (FABP) families. The aim of this study was to determine the influence of birth weight on key adipose and skeletal muscle tissue regulating genes. Piglets from 11 litters were ranked according to birth weight and 3 from each litter assigned to small, normal, or large-birth weight groups. Tissue samples were collected on day 7 or 14. Plasma metabolite concentrations and the expression ofPPARG2,PPARA,FABP3, andFABP4genes were determined in subcutaneous adipose tissue and skeletal muscle. Adipocyte number and area were determined histologically. Expression ofFABP3and4was significantly reduced in small and large, compared with normal, piglets in adipose tissue on day 7 and in skeletal muscle on day 14. On day 7,PPARAandPPARG2were significantly reduced in adipose tissue from small and large piglets. Adipose tissue from small piglets contained more adipocytes than normal or large piglets. Birth weight had no effect on adipose tissue and skeletal muscle lipid content. Low-birth weight is associated with tissue-specific and time-dependent effects on lipid-regulating genes as well as morphological changes in adipose tissue. It remains to be seen whether these developmental changes alter an individual's susceptibility to metabolic syndrome.

From Cradle to Classroom: High Birth Weight and Cognitive Outcomes

2010 ◽  
Vol 13 (2) ◽  
Author(s):  
Resul Cesur ◽  
Inas Rashad Kelly
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
The United States ◽  
Overweight And Obesity ◽  
Cognitive Outcomes ◽  
Policy Implications ◽  
High Birth Weight ◽  
Overweight Child ◽  
Negative Effects ◽  
Lower Test

While the effects of low birth weight have long been explored, the literature on the effects of high birth weight is sparse. However, with increasing obesity rates in the United States, high birth weight has become a potential concern, and has been associated in the medical literature with an increased likelihood of becoming an overweight child, adolescent, and subsequently an obese adult. Overweight and obesity, in turn, are associated with a host of negative effects, including lower test scores in school and lower labor market prospects when adults. If studies only focus on low birth weight, they may underestimate the effects of ensuring that mothers receive adequate support during pregnancy. This study finds that cognitive outcomes are adversely affected not only by low birth weight (<2500 grams) but also by high birth weight (>4500 grams). Our results have policy implications in terms of provision of support for pregnant women.

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