Association of weather, air pollutants, and seasonal influenza with chronic obstructive pulmonary disease hospitalization risks

Abstract Background Previous studies have shown inconsistent results regarding the impact of traffic pollution on the prevalence of chronic obstructive pulmonary disease (COPD). Therefore, using frequency matching and propensity scores, we explored the association between traffic pollution and COPD in a cohort of 8284 residents in a major agricultural county in Taiwan. Methods All subjects completed a structured questionnaire interview and health checkups. Subjects with COPD were identified using Taiwan National Health Insurance Research Databases. A hybrid kriging/LUR model was used to identify levels of traffic-related air pollutants (PM2.5 and O3). Multiple logistic regression models were used to calculate the prevalence ratios (PRs) of COPD and evaluate the role played by traffic-related indices between air pollutants and COPD. The distributed lag nonlinear model was applied in the analysis; we excluded current or ever smokers to perform the sensitivity analysis. Results Increased PRs of COPD per SD increment of PM2.5 were 1.10 (95% CI 1.05–1.15) and 1.25 (95% CI 1.13–1.40) in the population with age and sex matching as well as propensity-score matching, respectively. The results of the sensitivity analysis were similar between the single and two pollutant models. PM2.5 concentrations were significantly associated with traffic flow including sedans, buses, and trucks (p < 0.01). The higher road area and the higher PM2.5 concentrations near the subject’s residence correlated with a greater risk of developing COPD (p for interaction < 0.01). Conclusions Our results suggest that long-term exposure to traffic-related air pollution may be positively associated with the prevalence of COPD. Graphical abstract

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Immunogenicity of trivalent seasonal influenza vaccine in patients with chronic obstructive pulmonary disease

Human Vaccines & Immunotherapeutics ◽

10.1080/21645515.2021.1911515 ◽

2021 ◽

pp. 1-6

Author(s):

Yan Li ◽

Ying Ma ◽

Zhijie An ◽

Chenyan Yue ◽

Yamin Wang ◽

...

Keyword(s):

Chronic Obstructive Pulmonary Disease ◽

Influenza Vaccine ◽

Pulmonary Disease ◽

Seasonal Influenza ◽

Chronic Obstructive ◽

Obstructive Pulmonary Disease ◽

Seasonal Influenza Vaccine

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Association Between Air Pollutants and Hospitalization with Chronic Obstructive Pulmonary Disease in Ganzhou, China

10.21203/rs.3.rs-789568/v1 ◽

2021 ◽

Author(s):

Xingye Zhou ◽

Chenwei Li ◽

Yanfang Gao ◽

Chuanfei Zhou ◽

Xiaokang Zhang

Keyword(s):

Chronic Obstructive Pulmonary Disease ◽

Pulmonary Disease ◽

Air Pollutants ◽

Hospitalized Patients ◽

Additive Models ◽

Quality Data ◽

Chronic Obstructive ◽

Obstructive Pulmonary Disease ◽

Copd Patients ◽

Lag Effect

Abstract Background. The evidence of the harm of air pollutants to respiratory health in inland cities in southern China is relatively limited. Therefore, it is necessary to explore the relationship between air pollutants and the number of hospitalized patients with chronic obstructive pulmonary disease (COPD) in this area.Method. The number of inpatients with COPD, air quality data and meteorological data in the First Affiliated Hospital of Gannan Medical University in Ganzhou City from 2016 to 2020 were collected. Generalized additive models were used to analyze the lagged effects of air pollutants and their health effects on the number of hospitalizations for COPD.Results. Among a variety of pollutants, the air pollutants PM2.5, PM10, NO2 and O3 in Ganzhou City have a significant impact on the number of hospitalized patients with COPD. Using PM2.5 as an example, the single day lag effect and cumulative lag effect reached their maximum at lag 6 day and lag 12 day, respectively, at which time the number of hospitalizations due to COPD increased by 2.82% and 6.60%, respectively. After adjusting for other pollutants, it was found that the impact of PM2.5 on the number of hospitalizations of COPD patients did not change much. Compared with the cold season, the changes of PM2.5, PM10 and O3 in warm season have a greater impact on the number of inpatients with COPD.Conclusions. The increased concentrations of PM2.5, PM10, NO2 and O3 in Ganzhou may increase the risk of COPD patients, which is one of the reasons for the increase in the number of COPD hospitalizations.

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Control of Chronic Obstructive Pulmonary Disease in Urban Populations: Findings From a Cross-Sectional Prevalence Survey in Shenzhen, China

10.21203/rs.3.rs-373932/v1 ◽

2021 ◽

Author(s):

Le-Cai Ji ◽

Jin-Feng Yin ◽

Chun-Rong Lu ◽

Hong-Yun Guan ◽

Wei-Guo Tan ◽

...

Keyword(s):

Risk Factors ◽

Chronic Obstructive Pulmonary Disease ◽

Pulmonary Disease ◽

Air Pollutants ◽

Early Stage ◽

Chronic Obstructive ◽

Cross Sectional ◽

Urban Populations ◽

Obstructive Pulmonary Disease ◽

Increased Risk

Abstract Background Lower is the prevalence of chronic obstructive pulmonary disease (COPD) among urban populations, but still high is the total burden. Limited evidence on the patients’ characteristics has been offered to guide the control of the disease in city settings. Methods We conducted a prevalence cross-sectional survey of COPD among residents aged ≥ 40 years in an emerging city Shenzhen, China. The multi-stage stratified random sampling method was applied to enroll eligible participants from September, 2018 to June, 2019. Tested by spirometry, individuals were diagnosed with COPD if the post-bronchodilator FEV1/FVC ratio was less than 0.7. Patients’ demographic and clinical characteristics, as well as estimates of the exposure to air pollutants, were included in the univariable and multivariable logistic regression models to assess the risk factors for COPD. Results A total of 4157 individuals were invited to participate in this survey and 3591 who had available spirometry results and epidemiological data were enrolled in the final analysis. The estimated standardized prevalence of COPD among residents over 40 years old in Shenzhen was 5.92% (95% confidential intervals 4.05–8.34). Risk factors for COPD included elder age (adjusted odds ratio 1.206, 95% CI 1.120–1.299 per 10-year increase), smoking over 20 pack-years (1.968, 1.367–2.832), history of chronic bronchitis (1.733, 1.036-2.900) or asthma (4.920, 2.425–9.982), and exposure to higher annual minimum concentrations of ambient SO2 (1.156, 1.053–1.270 per 1-µg/m3 increase). Among 280 spirometry-diagnosed patients, most (221, 78.93%) patients were classified as mild COPD (GOLD stage I). The COPD assessment tests showed 24.7% (58/235) patients had severe symptoms with a total score ≥ 10, and 82.6% (194/235) were clinically symptomatic with a total score ≥ 2. Conclusions This survey found a low prevalence of COPD in Shenzhen and most patients had mild symptoms, thus recommended screening using spirometry in primary health care to detect early-stage COPD. Increased risk from the exposure to air pollutants also indicated the urgent need for environmental improvement in city settings.

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Influenza Vaccine Effectiveness in Preventing Hospitalizations in Older Patients With Chronic Obstructive Pulmonary Disease

The Journal of Infectious Diseases ◽

10.1093/infdis/jiz419 ◽

2019 ◽

Vol 221 (1) ◽

pp. 42-52 ◽

Cited By ~ 1

Author(s):

Andrea S Gershon ◽

Hannah Chung ◽

Joan Porter ◽

Michael A Campitelli ◽

Sarah A Buchan ◽

...

Keyword(s):

Chronic Obstructive Pulmonary Disease ◽

Older Adults ◽

Influenza Vaccine ◽

Influenza Vaccination ◽

Pulmonary Disease ◽

Seasonal Influenza ◽

Vaccine Effectiveness ◽

Chronic Obstructive ◽

Obstructive Pulmonary Disease ◽

Seasonal Influenza Vaccine

Abstract Background Annual influenza immunization is recommended for people with chronic obstructive pulmonary disease (COPD) by all major COPD clinical practice guidelines. We sought to determine the seasonal influenza vaccine effectiveness (VE) against laboratory-confirmed influenza-associated hospitalizations among older adults with COPD. Methods We conducted a test-negative study of influenza VE in community-dwelling older adults with COPD in Ontario, Canada using health administrative data and respiratory specimens collected from patients tested for influenza during the 2010–11 to 2015–16 influenza seasons. Influenza vaccination was ascertained from physician and pharmacist billing claims. Multivariable logistic regression was used to estimate the adjusted odds ratio of influenza vaccination in people with, compared to those without, laboratory-confirmed influenza. Results Receipt of seasonal influenza vaccine was associated with an adjusted 22% (95% confidence interval [CI], 15%–27%) reduction in laboratory-confirmed influenza-associated hospitalization. Adjustment for potential misclassification of vaccination status increased this to 43% (95% CI, 35%–52%). Vaccine effectiveness was not found to vary by patient- or influenza-related variables. Conclusions During the studied influenza seasons, influenza vaccination was at least modestly effective in reducing laboratory-confirmed influenza-associated hospitalizations in people with COPD. The imperfect effectiveness emphasizes the need for better influenza vaccines and other preventive strategies.

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