P.0158 Psychosis risk candidate ZNF804A - a key player in synaptic functioning by regulating local protein synthesis?

2021 ◽  
Vol 53 ◽  
pp. S115
Author(s):  
L. Sichlinger ◽  
A. Aabdien ◽  
P. Raval ◽  
L. Tanangonan ◽  
A. Vernon ◽  
...  
Keyword(s):  
Protein Synthesis ◽  
Local Protein Synthesis ◽  
Psychosis Risk ◽  
Local Protein

scholarly journals W84. PSYCHOSIS RISK CANDIDATE ZNF804A - A KEY PLAYER IN SYNAPTIC FUNCTIONING BY REGULATING LOCAL PROTEIN SYNTHESIS?

2021 ◽  
Vol 51 ◽  
pp. e188-e189
Author(s):  
Laura Sichlinger ◽  
Afra Aabdien ◽  
Pooja Raval ◽  
Anthony Vernon ◽  
Deepak Srivastava
Keyword(s):  
Protein Synthesis ◽  
Local Protein Synthesis ◽  
Psychosis Risk ◽  
Local Protein

Dendritic ribosomes suggest local protein synthesis during estrous synaptogenesis

Neuroreport ◽  
2003 ◽  
Vol 14 (10) ◽  
pp. 1357-1360 ◽  
Author(s):  
J. Brian McCarthy ◽  
Teresa A. Milner
Keyword(s):  
Protein Synthesis ◽  
Local Protein Synthesis ◽  
Local Protein

Hippocampal long term memory: Effect of the cholinergic system on local protein synthesis

2013 ◽  
Vol 106 ◽  
pp. 246-257 ◽  
Author(s):  
Daniele Lana ◽  
Francesca Cerbai ◽  
Jacopo Di Russo ◽  
Francesca Boscaro ◽  
Ambra Giannetti ◽  
...  
Keyword(s):  
Protein Synthesis ◽  
Memory Effect ◽  
Cholinergic System ◽  
Long Term Memory ◽  
Term Memory ◽  
Local Protein Synthesis ◽  
Local Protein

scholarly journals Differential requirement of F-actin and microtubule cytoskeleton in cue-induced local protein synthesis in axonal growth cones

2015 ◽  
Vol 10 (1) ◽  
pp. 3 ◽  
Author(s):  
Michael Piper ◽  
Aih Lee ◽  
Francisca van Horck ◽  
Heather McNeilly ◽  
Trina Lu ◽  
...  
Keyword(s):  
Protein Synthesis ◽  
Axonal Growth ◽  
Growth Cones ◽  
Microtubule Cytoskeleton ◽  
Local Protein Synthesis ◽  
Local Protein

Translating regeneration: Local protein synthesis in the neuronal injury response

2019 ◽  
Vol 139 ◽  
pp. 26-36 ◽  
Author(s):  
Sandip Koley ◽  
Meir Rozenbaum ◽  
Mike Fainzilber ◽  
Marco Terenzio
Keyword(s):  
Protein Synthesis ◽  
Neuronal Injury ◽  
Injury Response ◽  
Local Protein Synthesis ◽  
Local Protein

scholarly journals Local protein synthesis of neuronal MT1-MMP for agrin-induced presynaptic development

Development ◽  
2021 ◽  
Vol 148 (10) ◽  
Author(s):  
Jun Yu ◽  
Marilyn Janice Oentaryo ◽  
Chi Wai Lee
Keyword(s):  
Protein Synthesis ◽  
Neuronal Development ◽  
Neuromuscular Junctions ◽  
Neuronal Cell ◽  
Time Lapse ◽  
Protein Synthesis Inhibitor ◽  
Synthesis Inhibitor ◽  
Local Protein Synthesis ◽  
Presynaptic Differentiation ◽  
Local Protein

ABSTRACT Upon the stimulation of extracellular cues, a significant number of proteins are synthesized distally along the axon. Although local protein synthesis is crucial for various stages throughout neuronal development, its involvement in presynaptic differentiation at developing neuromuscular junctions remains unknown. By using axon severing and microfluidic chamber assays, we first showed that treatment of a protein synthesis inhibitor, cycloheximide, inhibits agrin-induced presynaptic differentiation in cultured Xenopus spinal neurons. Newly synthesized proteins are prominently detected, as revealed by the staining of click-reactive cell-permeable puromycin analog O-propargyl-puromycin, at agrin bead-neurite contacts involving the mTOR/4E-BP1 pathway. Next, live-cell time-lapse imaging demonstrated the local capturing and immobilization of ribonucleoprotein granules upon agrin bead stimulation. Given that our recent study reported the roles of membrane-type 1 matrix metalloproteinase (MT1-MMP) in agrin-induced presynaptic differentiation, here we further showed that MT1-MMP mRNA is spatially enriched and locally translated at sites induced by agrin beads. Taken together, this study reveals an essential role for axonal MT1-MMP translation, on top of the well-recognized long-range transport of MT1-MMP proteins synthesized from neuronal cell bodies, in mediating agrin-induced presynaptic differentiation.

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