Use of inhaled loxapine in acute psychiatric agitation

2016 ◽  
Vol 33 (S1) ◽  
pp. s228-s228
Author(s):  
S. Ovejero ◽  
M. Iza ◽  
S. Vallejo ◽  
C. Vera ◽  
A. Sedano ◽  
...  
Keyword(s):  
Rating Scale ◽  
Psychiatric Inpatient ◽  
Physical Restraint ◽  
Inpatient Unit ◽  
Young Mania ◽  
Non Invasive ◽  
Psychiatric Inpatient Unit ◽  
Syndrome Scale ◽  
Competing Interest ◽  
Negative Syndrome

ObjectivesThe aim of this work is to study the efficacy of loxapine inhalation powder on agitated patients in a psychiatric inpatient unit.MethodsNineteen patients sample, with an average age of 39.4 years old, diagnosed with schizophrenia, bipolar disorder or schizoaffective disorder. Patients inhaled loxapine 10 mg, using the staccato system, when they suffered a psychomotor agitation. The clinical efficacy was measured as a change from baseline in the Positive and Negative Syndrome Scale-Excited Component (PANSS-EC) and in the Young Mania Rating Scale (YMRS) one hour after the administration of loxapine.ResultsA mean of 9.8 points reduction (22.6 at baseline and 12.7 one hour after the administration) was found on the PANSS-EC (t-test, P < .001) and 68.4% of the patients were considered responders as they obtained a reduction of at least 40% of the basal score. On 10 of the total of the agitated patients showed an improvement of the psychomotor excitement, and this allowed the clinicians to remove the physical restraint; on 6 of the agitated patients the physical restraint could be avoided during the whole treatment; and 3 of the patients experienced a reduction of the excitement. The reduction on PANNS-EC on the latest group was not statistically significant (t-test, P = .121).ConclusionsInhaled loxapine was a non-invasive, rapid and effective alternative treatment for acute agitation in a psychiatric inpatient unit. It resulted more effective on mild and moderate cases; not been significantly effective on the severe cases of agitation.Disclosure of interestThe authors have not supplied their declaration of competing interest.

Συχνότητα των ήπιων νευρολογικών σημείων σε ασθενείς με σχιζοφρενικού τύπου ψύχωση

2012 ◽  
Author(s):  
Παναγιώτης Παναγιωτίδης
Keyword(s):  
Trait Anxiety ◽  
Rating Scale ◽  
Depression Scale ◽  
Hand Preference ◽  
T Test ◽  
State Trait Anxiety Inventory ◽  
Greek Version ◽  
Young Mania ◽  
Syndrome Scale ◽  
Negative Syndrome

Η παρά τη κλίνη εξέταση των νευρολογικών διαταραχών, μέσω μίας τυπικής νευρολογικής κλινικής εξέτασης θεωρείται ως μία άμεση και ανέξοδη μέθοδος για την αξιολόγηση της εγκεφαλικής δυσλειτουργίας στη σχιζοφρένεια. Κατά τη διάρκεια των τελευταίων σαράντα ετών οι ερευνητικές εργασίες αναφέρουν συστηματικά την αυξημένη παρουσία των ήπιων νευρολογικών σημείων (ΗΝΣ) στους ασθενείς με σχιζοφρένεια, σε σύγκριση με τον υγιή πληθυσμό ή τους μη-ψυχωτικούς ψυχιατρικούς ασθενείς. Ωστόσο, η λειτουργική τους συσχέτιση παραμένει ασαφής και η ειδικότητά τους έχει συχνά αμφισβητηθεί, αν και υπάρχουν ενδείξεις μίας σχετικής ειδικότητας ως προς τη διάγνωση ή τη συμπτωματολογία. Παράγοντες όπως οι ανεπιθύμητες ενέργειες των νευροληπτικών φαρμάκων, το φύλο, η ηλικία ή το οικογενειακό ψυχιατρικό ιστορικό, θεωρείται ότι επηρεάζουν τα αποτελέσματα της νευρολογικής εκτίμησης, ενώ μόνο ένας σχετικά μικρός αριθμός ερευνών αναφέρει δεδομένα μίας μακροχρόνιας παρακολούθησης των ΗΝΣ σε έναν επαρκή αριθμό ατόμων προκειμένου να αξιολογηθεί μία πιθανή έκπτωση των νευρολογικών λειτουργιών. Η παρούσα μελέτη προσπάθησε να διερευνήσει τη συχνότητα και τη φύση των ΗΝΣ σε ασθενείς με σχιζοφρένεια, καθώς και σε μία ομάδα υγιών μαρτύρων. Στοχεύσαμε στη διερεύνηση των διαφορών μεταξύ των μελετώμενων πληθυσμών και των συσχετίσεων μεταξύ συγκεκριμένων ομάδων νευρολογικών σημείων και κλινικών, κοινωνικοδημογραφικών και θεραπευτικών χαρακτηριστικών του πληθυσμού των ασθενών, κατά την αρχική εκτίμηση, καθώς και μετά την πάροδο δώδεκα μηνών. Συνολικά εντάχθηκαν στη μελέτη 133 νοσηλευόμενοι και εξωτερικοί ασθενείς. Οι διαγνώσεις τέθηκαν βάση της ελληνικής έκδοσης 5.0.0. της σύντομης διεθνούς νευροψυχιατρικής συνέντευξης (Mini International Neuropsychiatric Interview, MINI Greek version 5.0.0.). Επιπλέον, 122 υγιείς μάρτυρες συμπεριλήφθηκαν στη μελέτη και αντιστοιχήθηκαν ως προς το φύλο και την ηλικία με τον πληθυσμό των ασθενών. Όλοι οι ενταχθέντες στη μελέτη υποβλήθηκαν αρχικά σε νευρολογική εξέταση εστιασμένη στη διερεύνηση των ΗΝΣ, βάση της Neurological Evaluation Scale (NES) κλίμακας. Τα εξωπυραμιδικά συμπτώματα εκτιμήθηκαν με τις κλίμακες Simpson-Angus Rating Scale (SARS) και Extrapyramidal Symptoms Rating Scale (ESRS). Τα ανευρεθέντα κλινικά συμπτώματα του πληθυσμού της μελέτης αξιολογήθηκαν με τις κλίμακες Positive And Negative Syndrome Scale (PANSS), Calgary Depression Scale for Schizophrenia (CDSS), State-Trait Anxiety Inventory form Y (STAI-T and STAI-S) και Young Mania Rating Scale (YMRS). Τέλος, η εκτίμηση της γενικής λειτουργικότητας έγινε βάση των οδηγιών της Αμερικάνικης Ψυχιατρικής Εταιρείας (κλίμακα GAF), ενώ η προτίμηση χρήσης των χεριών εκτιμήθηκε με την κλίμακα Annett Hand Preference Questionnaire (AHPQ). Για λόγους στατιστικής ανάλυσης υιοθετήθηκε τιμή p τέτοια ώστε να είναι επαρκής για πολλαπλές συγκρίσεις και ορίστηκε σε επίπεδο p<0.001. Για την ανάλυση των δεδομένων χρησιμοποιήθηκε το t-test για ένα δείγμα, η δοκιμασία x2, η δοκιμασία t-test για ανεξάρτητα δείγματα και ο συντελεστής συσχέτισης Pearson, όπου αυτό απαιτείτο. Συμπεράσματα: Τα ήπια νευρολογικά σημεία είναι εξαιρετικά συχνά σε ασθενείς με σχιζοφρένεια (90%), ενώ μάλλον σπάνια σε υγιείς μάρτυρες (12%), εύρημα κοινό σε όλες τις υποομάδες στις οποίες κατηγοριοποιούνται. Η παρουσία τους έχει μορφή δομικών χαρακτηριστικών (trait-like), με σταθερότητα στο χρόνο, και είναι ανεξάρτητα από κοινωνικοδημογραφικούς παράγοντες, κλινικά χαρακτηριστικά της νόσου και την υπάρχουσα φαρμακοθεραπεία, αν και η ύπαρξή τους ενδεχομένως υποδεικνύει νόσο με φτωχότερη έκβαση. Δε φαίνεται να επιδεινώνονται με το πέρασμα της ηλικίας, τουλάχιστον μέχρι την ηλικία των 65 ετών.

scholarly journals The Presentation and Treatment Response of Catatonia in Patients Admitted to the Psychiatric Inpatient Unit at Jimma University Medical Center, Ethiopia

2020 ◽  
Vol 2020 ◽  
pp. 1-6
Author(s):  
Yimenu Yitayih ◽  
Elias Tesfaye ◽  
Kristina Adorjan
Keyword(s):  
Low Income ◽  
Rating Scale ◽  
Medical Center ◽  
Psychiatric Inpatient ◽  
Inpatient Unit ◽  
Response To Treatment ◽  
Symptom Profile ◽  
Psychiatric Inpatient Unit ◽  
Common Diagnosis ◽  
Jimma University

Background. Catatonia is among the most mysterious and poorly understood neuropsychiatric syndrome. It is underresearched and virtually forgotten but still a frequent neuropsychiatric phenotype in both developed and low-income countries. Catatonia is associated with a number of medical complications like pulmonary embolism, dehydration, or pneumonia if it is not treated and managed adequately. In Ethiopia, however, almost no studies are available to describe the symptoms and the response to treatment in patients with catatonia. The aim of this retrospective study was therefore to describe the symptom profile of catatonia and to evaluate the treatment and outcome of catatonia in patients admitted to the psychiatric inpatient unit at Jimma University, Ethiopia. Method. Detailed treatment records of all inpatients were reviewed for the period from May 2018 to April 2019. All patients with catatonia at the inpatient unit of Jimma University Medical Center were assessed with the Bush-Francis Catatonia Rating Scale (BFCRS), and all comorbid psychiatric diagnoses were made according to the criteria of the Diagnostic Statistical Manual V. The presence and severity of catatonia were assessed by using the BFCRS at baseline and at discharge from the hospital. Result. In the course of one year, a total of 18 patients with the diagnosis of catatonia were admitted. The mean age of the participants was 22.8 years (SD 5.0; range: 15 to 34 years). The most common diagnosis associated with catatonia was schizophrenia (n=12; 66.7%), followed by severe depressive disorders (n=4; 22.2%). Mutism, posture, and withdrawal were registered in all patients (n=18, 100%). All patients received an injection of diazepam and had improved at discharge. Conclusion. Our study provides further evidence that catatonia is most commonly associated with schizophrenia, followed by major depressive disorder, and that mutism, posturing, and withdrawal are the most common signs and symptoms of catatonia.

scholarly journals Delusions in a Sample of Patients with Schizophrenia and Bipolar Disorder: The same or different?

QJM ◽  
2020 ◽  
Vol 113 (Supplement_1) ◽  
Author(s):  
H M E Azzam ◽  
M A Hamed ◽  
Y A Elhawary ◽  
A H A Mohammed
Keyword(s):  
Bipolar Disorder ◽  
Negative Symptoms ◽  
Rating Scale ◽  
Psychotic Symptoms ◽  
University Hospitals ◽  
Young Mania ◽  
Syndrome Scale ◽  
Psychotic Features ◽  
Negative Syndrome ◽  
Depressive Episodes

Abstract Background Growing evidences indicate that there is overlapping between schizophrenia (SCZ) and bipolar disorder (BP) in neurobiology, phenomenology or even in changing of diagnosis from schizophrenia to bipolar disorder or vice versa. Psychotic symptoms can be observed during manic or depressive episodes in bipolar disorder. While manic or depressive episodes can be observed between or during psychotic episodes in schizophrenia. Aim of the work To describe delusional types present in both groups of study sample: a group of patients with schizophrenia and a group of patients with bipolar disorder accompanied by psychotic features. Also to compare between types of delusions in patients with schizophrenia and patients with bipolar disorder accompanied by psychotic features. Patients and Methods total 80 patients (40 in group of Schizophrenia and 40 in group of bipolar disorder accompanied by psychotic features) were selected as convenient sampling from patients during the first two weeks of their admission in the Institute of Psychiatry, Ain Shams University Hospitals. Nature and types of the delusions were assessed by using Scale for the Assessment of Negative Symptoms (SANS), Positive and Negative Syndrome Scale (PANSS) and Young Mania Rating Scale (YMRS) in study period from 1st of October 2017 till 1st of April 2018. Results Delusion of persecution is the commonest delusion in group of SCZ (37.5%), while delusion of grandiosity is the commonest delusion in group of BP accompanied by psychotic features (32.5%). Monothematic delusions are doubling frequent in group of BP accompanied by psychotic features (75%) if it compared to group of SCZ (35%). Non systematized delusions are the dominant in group of SCZ (45%) while most delusions in other group are some systematized (45%). Delusions of most patients in group of SCZ are incongruent with mood (77.5%). While delusions of most patients in group of BP accompanied by psychotic features are congruent with mood (65%). The presence of delusion is positively correlated to higher score of: SANS (in both groups), PANSS (in both groups) and YMRS (in BP accompanied by psychotic features). Conclusion delusions of schizophrenia are different in nature and types when it compared to delusions of bipolar disorder.

Participant Reactions to Suicide-Focused Research

Crisis ◽  
2020 ◽  
Vol 41 (5) ◽  
pp. 367-374
Author(s):  
Sarah P. Carter ◽  
Brooke A. Ammerman ◽  
Heather M. Gebhardt ◽  
Jonathan Buchholz ◽  
Mark A. Reger
Keyword(s):  
Medical Records ◽  
Research Study ◽  
Small Sample Size ◽  
Psychiatric Inpatient ◽  
Small Sample ◽  
Inpatient Unit ◽  
Online Laboratory ◽  
Psychiatric Inpatient Unit ◽  
Before And After ◽  
Participant Reactions

Abstract. Background: Concerns exist regarding the perceived risks of conducting suicide-focused research among an acutely distressed population. Aims: The current study assessed changes in participant distress before and after participation in a suicide-focused research study conducted on a psychiatric inpatient unit. Method: Participants included 37 veterans who were receiving treatment on a psychiatric inpatient unit and completed a survey-based research study focused on suicide-related behaviors and experiences. Results: Participants reported no significant changes in self-reported distress. The majority of participants reported unchanged or decreased distress. Reviews of electronic medical records revealed no behavioral dysregulation and minimal use of as-needed medications or changes in mood following participation. Limitations: The study's small sample size and veteran population may limit generalizability. Conclusion: Findings add to research conducted across a variety of settings (i.e., outpatient, online, laboratory), indicating that participating in suicide-focused research is not significantly associated with increased distress or suicide risk.

scholarly journals The experience of parents faced with the admission of their adolescent to a child and adolescent psychiatric inpatient unit. A qualitative study with focus groups

2021 ◽  
Author(s):  
Beatriz Merayo-Sereno ◽  
Aránzazu Fernández-Rivas ◽  
Keyth Lany de Oliveira-Silva ◽  
Francisco-Javier Sánchez-Andérez ◽  
Eva Sesma-Pardo ◽  
...  
Keyword(s):  
Focus Groups ◽  
Psychiatric Hospitalization ◽  
Emotional Experience ◽  
Psychiatric Inpatient ◽  
Health Behavior Change ◽  
Child And Adolescent ◽  
Inpatient Unit ◽  
Entire Family ◽  
Parental Experience ◽  
Psychiatric Inpatient Unit

AbstractThe admission of an adolescent to a child and adolescent psychiatric inpatient unit has a serious impact on the entire family unit. The emotional experience of those primary caregivers has been scarcely studied qualitatively despite being recommended by previous research. This study aims to examine the experience of parents of adolescents with mental health needs that required psychiatric hospitalization in a child and adolescent unit. Qualitative cross-sectional research was carried out under the recommendations of Grounded Theory with three Focus Groups of parents (N = 22) of adolescents who required psychiatric hospitalization in a child and adolescent ward. The COREQ quality criteria were applied. The parental experience implies a high level of emotional suffering modulated by feelings of guilt, stigma, parental awareness of their child’s illness and the passage of time. The use of Prochaska’s and Diclemente’s trans-theoretical model of health behavior change is useful in understanding the parental experience.

scholarly journals FAMILY EXPECTATIONS ABOUT A PSYCHIATRIC INPATIENT UNIT

2015 ◽  
Vol 24 (4) ◽  
pp. 984-992 ◽  
Author(s):  
Gustavo Costa de Oliveira ◽  
Jacó Fernando Schneider ◽  
Cíntia Nasi ◽  
Marcio Wagner Camatta ◽  
Agnes Olschowsky
Keyword(s):  
Social Relations ◽  
Psychiatric Inpatient ◽  
Family Care ◽  
Inpatient Unit ◽  
University Hospital ◽  
Family Expectations ◽  
Phenomenological Sociology ◽  
Psychiatric Inpatient Unit ◽  
The Social ◽  
The Family

ABSTRACT We aimed to understand the expectations of families about a Psychiatric Inpatient Unit in the perspective of Alfred Schutz's phenomenological sociology. This is a qualitative and phenomenological research, with families of patients at a psychiatric inpatient unit of a university hospital in the state of Rio Grande do Sul, Brazil. Data were collected through phenomenological interviews, and the analysis was constructed in the light of phenomenological sociology. The results show that the expectations of the family in the Psychiatric Inpatient Unit are related to the interpretation and experiences they have in the world of everyday life; that these expectations should be valued in patient and family care; and that they may integrate the family in care for the patient. We hope to contribute so that professionals and managers reflect about the importance of understanding the expectations of families on a Unit, aiming to implement more effective health actions, based on the social relations among the subjects.

scholarly journals Duration of untreated psychosis of first-episode psychotic disorders in Yogyakarta, Indonesia

2019 ◽  
Vol 7 (2) ◽  
pp. 61-64
Author(s):  
Carla R. Marchira ◽  
Irwan Supriyanto
Keyword(s):  
Psychotic Disorders ◽  
Rating Scale ◽  
First Episode ◽  
Medical Facility ◽  
Duration Of Untreated Psychosis ◽  
Global Assessment Of Functioning ◽  
Global Functioning ◽  
Syndrome Scale ◽  
Negative Syndrome ◽  
Gaf Scores

Introduction: Duration of untreated psychosis (DUP) is an important predictor for prognosis in first episode of psychotic disorders. Caregivers often seek help from alternative healers first and health professional later. These would delay proper treatments for the patients, resulting in more severe symptoms and lower functioning on their visit to medical facility. The present study aims to find the association between DUP, symptoms severity, and global functioning in patients with first-episode psychotic disorders. Methods: We identified 100 patients with first episode of psychotic disorders and their caregivers. The instruments used were Brief Psychotic Rating Scale (BPRS), Positive and Negative Syndrome Scale (PANSS), Premorbid Schizoid-Schizotypal Traits (PSST), and Global Assessment of Functioning (GAF). Results: There were no significant association between BPRS, PANSS, PSST, and GAF scores and DUP in our subjects. Nevertheless, we found that men had significantly longer DUP compared to women. Conclusion: We found significant association between sex and DUP in this study. Longer DUP leads to delayed treatments and poorer prognosis. Further study is required to confirm our finding.

scholarly journals Patient access to psychiatric records: experience in an in-patient unit

1995 ◽  
Vol 19 (2) ◽  
pp. 87-90 ◽  
Author(s):  
Nick Kosky ◽  
Tom Burns
Keyword(s):  
Educational Attainment ◽  
Maintenance Treatment ◽  
Junior Doctor ◽  
Psychiatric Inpatient ◽  
Inpatient Unit ◽  
Therapeutic Relationships ◽  
Patient Access ◽  
Psychiatric Inpatient Unit ◽  
Lower Educational Attainment

Forty of 46 consecutive admissions to a psychiatric inpatient unit were encouraged to read their admission notes and discuss them with the Junior doctor. The offer was withheld for two patients with organic impairment. Twenty-eight patients (including 12 on compulsory admissions) accepted the offer. The 12 who refused were characterised by overall lower educational attainment. Diagnosis raised only a few problems, prognosis and maintenance treatment being the focus of most discussions. There was no evidence of a deterioration in the quality of notes or therapeutic relationships as a consequence of access. Only in one case was the exercise judged ‘harmful’, but ‘useful or essential’ in 22. Possible benefits for both patients and doctor are explored.

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