SUMMARYThis study was conducted to investigate the level of cardiac and oxidative stress markers in camels infected withTrypanosoma evansiand to explore the diagnostic and prognostic value of cardiac troponin I (cTnI) and creatine kinase-myocardial band (CK-MB) in response to infection. Seventy four dromedary camels with clinical and laboratory evidence of trypanosomosis and 20 healthy controls were included in this study. Serum cTnI, CK-MB, CK, malondialdehyde (MDA) and super oxide dismutase (SOD) were measured. The values of cTnI, CK-MB, CK and MDA were significantly higher, whereas SOD level was lower inT. evansiinfected camel. Successfully treated camels (n= 43) had lower levels of cTnI, CK-MB, CK and MDA, but higher level of SOD compared to camels with treatment failure. Both cTnI and CK-MB showed high degree of accuracy in predicting treatment outcome (successvsfailure). The area under the curve for cTnI and CK-MB was 0·98 and 0·93, respectively. However, cTnI showed better sensitivity and specificity than CK-MB (Se = 96·8%vs83·9% and Sp = 100%vs88·5%, respectively). These results suggest that cTnI and CK-MB could be used as diagnostic and prognostic biomarkers in camels infected withT. evansi.
Effect of iron supplementation on intestinal function
and oxidative stress in piglets with induced colitis