Reduced pretreatment ovarian reserve in premenopausal female patients with Hodgkin lymphoma or non-Hodgkin-lymphoma—evaluation by using antimüllerian hormone and retrieved oocytes

Objective: To study the importance of immunological screening (CH50, C3, C4) to determine the correlation between the ovarian reserve and complement pathway. Design: A cross-sectional multivariate study. Setting: Single tertiary referral center. Patients: 40 Women with infertility diagnosis who underwent In Vitro Fertilization (IVF). Intervention(s): Basal blood samples collected to measure complement pathway and antimüllerian hormone. Main Outcome Measure(s): To correlate complement pathways (CH50 levels) with AMH. Results: The complement system and ovarian reserve were studied in 40 women aged from 28-48 years (mean=37.87 years), finding the values of CH50 65-268 CAE (mean=153.2 CAE), C3 13.9- 183mg/dl (mean=128.52mg/dl), C4 11.5-106mg/dl (mean=29.86mg/dl), AMH 0.10-3.9ng/dl (mean=1.32ng/dl). A multivariate analysis comparison was also conducted yielding significant results: negative correlation between AMH and age (Spearman correlation -0.6; P=0.001), as well as between AMH and CH50 (Spearman correlation -0.4; P=0.0129). Conclusion: High CH50 levels are correlated with an AMH decrease and it could be accordingly associated with age-related chronic inflammation. Capsule: High levels of CH50 are correlated with a decrease in AMH levels and could also be considered as a marker of poor response in IVF cycles.

Download Full-text

Potential Mechanisms for Racial and Ethnic Differences in Antimüllerian Hormone and Ovarian Reserve

International Journal of Endocrinology ◽

10.1155/2013/818912 ◽

2013 ◽

Vol 2013 ◽

pp. 1-7 ◽

Cited By ~ 29

Author(s):

Reshef Tal ◽

David B. Seifer

Keyword(s):

Ethnic Groups ◽

Racial Differences ◽

Ethnic Differences ◽

Ovarian Reserve ◽

Pubertal Timing ◽

Reproductive Potential ◽

Racial And Ethnic Differences ◽

Antimullerian Hormone ◽

Antimüllerian Hormone ◽

Racial Ethnic

Accumulating evidence suggests that reproductive potential and function may be different across racial and ethnic groups. Racial differences have been demonstrated in pubertal timing, infertility, outcomes after assisted reproductive technology (ART) treatment, and reproductive aging. Recently, racial differences have also been described in serum antimüllerian hormone (AMH), a sensitive biomarker of ovarian reserve, supporting the notion that ovarian reserve differs between racial/ethnic groups. The existence of such racial/ethnic differences in ovarian reserve, as reflected by AMH, may have important clinical implications for reproductive endocrinologists. However, the mechanisms which may underlie such racial differences in ovarian reserve are unclear. Various genetic factors and environmental factors such as obesity, smoking, and vitamin D deficiency which have been shown to correlate with serum AMH levels and also display significant racial/ethnic variations are discussed in this review. Improving our understanding of racial differences in ovarian reserve and their underlying causes may be essential for infertility treatment in minority women and lead to better reproductive planning, improved treatment outcomes, and timely interventions which may prolong reproductive lifespan in these women.

Download Full-text

Role of ovarian reserve markers, antimüllerian hormone and antral follicle count, as aneuploidy markers in ongoing pregnancies and miscarriages

Fertility and Sterility ◽

10.1016/j.fertnstert.2015.02.022 ◽

2015 ◽

Vol 103 (5) ◽

pp. 1221-1227.e2 ◽

Cited By ~ 14

Author(s):

Maribel Grande ◽

Virginia Borobio ◽

Mar Bennasar ◽

Iosifina Stergiotou ◽

Immaculada Mercadé ◽

...

Keyword(s):

Ovarian Reserve ◽

Antral Follicle ◽

Antral Follicle Count ◽

Antimullerian Hormone ◽

Antimüllerian Hormone ◽

Ovarian Reserve Markers

Download Full-text

Early follicular antimüllerian hormone as an indicator of ovarian reserve

Fertility and Sterility ◽

10.1016/j.fertnstert.2005.09.019 ◽

2006 ◽

Vol 85 (3) ◽

pp. 592-596 ◽

Cited By ~ 159

Author(s):

Cem Fiçicioǧlu ◽

Tayfun Kutlu ◽

Elif Baglam ◽

Zeynep Bakacak

Keyword(s):

Ovarian Reserve ◽

Antimullerian Hormone ◽

Antimüllerian Hormone

Download Full-text

Why we may abandon basal follicle-stimulating hormone testing: a sea change in determining ovarian reserve using antimüllerian hormone

Fertility and Sterility ◽

10.1016/j.fertnstert.2013.03.001 ◽

2013 ◽

Vol 99 (7) ◽

pp. 1825-1830 ◽

Cited By ~ 46

Author(s):

James P. Toner ◽

David B. Seifer

Keyword(s):

Ovarian Reserve ◽

Follicle Stimulating Hormone ◽

Antimullerian Hormone ◽

Antimüllerian Hormone ◽

Stimulating Hormone

Download Full-text

Faculty Opinions recommendation of One-year follow-up of serum antimüllerian hormone levels in patients with cystectomy: are different sequential changes due to different mechanisms causing damage to the ovarian reserve?

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.717999674.793481034 ◽

2013 ◽

Author(s):

Jim Tsaltas

Keyword(s):

Ovarian Reserve ◽

Hormone Levels ◽

Antimullerian Hormone ◽

Antimüllerian Hormone ◽

One Year

Download Full-text

Antimullerian Hormone Changes after Laparoscopic Ovarian Cystectomy for Endometrioma Compared with the Nonovarian Conditions

Minimally Invasive Surgery ◽

10.1155/2014/654856 ◽

2014 ◽

Vol 2014 ◽

pp. 1-5

Author(s):

Chamnan Tanprasertkul ◽

Sakol Manusook ◽

Charintip Somprasit ◽

Sophapun Ekarattanawong ◽

Opas Sreshthaputra ◽

...

Keyword(s):

Ovarian Reserve ◽

Negative Impact ◽

Pelvic Surgery ◽

Ovarian Cystectomy ◽

Antimullerian Hormone ◽

Significant Difference ◽

The Mean ◽

Antimüllerian Hormone ◽

A Prospective Study ◽

The Impact

Laparoscopic ovarian cystectomy is recommended for surgical procedure of endometrioma. The negative impact on ovarian reserve following removal had been documented. Little evidence had been reported for nonovarian originated effects.Objective.To evaluate the impact of laparoscopic ovarian cystectomy for endometrioma on ovarian reserve, measured by serum antimullerian hormone (AMH), compared to nonovarian pelvic surgery.Materials and Methods.A prospective study was conducted. Women who underwent laparoscopic ovarian cystectomy (LOC) and laparoscopic nonovarian pelvic surgery (NOS) were recruited and followed up through 6 months. Clinical baseline data and AMH were evaluated.Results.39 and 38 participants were enrolled in LOC and NOS groups, respectively. Baseline characteristics (age, weight, BMI, and height) and preoperative AMH level between 2 groups were not statistically different. After surgery, AMH of both groups decreased since the first week, at 1 month and at 3 months. However, as compared to the LOC group at 6 months after operation, the mean AMH of the NOS group had regained its value with a highly significant difference.Conclusion.This study demonstrated the negative impact of nonovarian or indirect effects of laparoscopic surgery to ovarian reserve. The possible mechanisms are necessary for more investigations.

Download Full-text