Detection of overlapping protein complexes in gene expression, phenotype and pathways of Saccharomyces cerevisiae using Prorank based Fuzzy algorithm

Gene ◽  
2016 ◽  
Vol 580 (2) ◽  
pp. 144-158 ◽  
Author(s):  
P. Manikandan ◽  
D. Ramyachitra ◽  
D. Banupriya
Keyword(s):  
Gene Expression ◽  
Saccharomyces Cerevisiae ◽  
Protein Complexes ◽  
Fuzzy Algorithm ◽  
Expression Phenotype ◽  
Gene Expression Phenotype

scholarly journals Gene Expression-Phenotype Associations in Adults with Eosinophilic Esophagitis

2017 ◽  
Vol 152 (5) ◽  
pp. S29
Author(s):  
Evan S. Dellon ◽  
Sara R. Selitsky ◽  
Robert M. Genta ◽  
Richard H. Lash ◽  
Joel S. Parker
Keyword(s):  
Gene Expression ◽  
Eosinophilic Esophagitis ◽  
Expression Phenotype ◽  
Gene Expression Phenotype

scholarly journals Cks1 Activates Transcription by Binding to the Ubiquitylated Proteasome

2010 ◽  
Vol 30 (15) ◽  
pp. 3894-3901 ◽  
Author(s):  
Roman Holic ◽  
Alexander Kukalev ◽  
Sophie Lane ◽  
Edward J. Andress ◽  
Ivy Lau ◽  
...  
Keyword(s):  
Gene Expression ◽  
Saccharomyces Cerevisiae ◽  
Transcriptional Activation ◽  
Protein Complexes ◽  
Cyclin Dependent Kinase ◽  
Transcription Activator ◽  
Large Protein ◽  
Ubiquitin Binding ◽  
Ubiquitin Binding Domain ◽  
Proteasome Subunits

ABSTRACT Cyclin-dependent kinase-associated protein 1 (Cks1) is involved in the control of the transcription of a subset of genes in addition to its role in controlling the cell cycle in the budding yeast Saccharomyces cerevisiae. By directly ligating Cks1 onto a GAL1 promoter-driven reporter, we demonstrated that Cks1 acts as a transcription activator. Using this method, we dissected the downstream events from Cks1 recruitment at the promoter. We showed that subsequent to promoter binding, Cdc28 binding is required to modulate the level of gene expression. The ubiquitin-binding domain of Cks1 is essential for implementing downstream transcription events, which appears to recruit the proteasome via ubiquitylated proteasome subunits. We propose that the selective ability of Cks1 to bind ubiquitin allows this small molecule the flexibility to bind large protein complexes with specificity and that this may represent a novel mechanism of regulating transcriptional activation.

scholarly journals Gene expression-phenotype associations in adults with eosinophilic esophagitis

2018 ◽  
Vol 50 (8) ◽  
pp. 804-811 ◽  
Author(s):  
Evan S. Dellon ◽  
Sara R. Selitsky ◽  
Robert M. Genta ◽  
Richard H. Lash ◽  
Joel S. Parker
Keyword(s):  
Gene Expression ◽  
Eosinophilic Esophagitis ◽  
Expression Phenotype ◽  
Gene Expression Phenotype

scholarly journals Nonlinear gene expression‐phenotype relationships contribute to variation and clefting in the A/WySn mouse

2019 ◽  
Vol 248 (12) ◽  
pp. 1232-1242 ◽  
Author(s):  
Rebecca M. Green ◽  
Courtney L. Leach ◽  
Virginia M. Diewert ◽  
Jose David Aponte ◽  
Eric J. Schmidt ◽  
...  
Keyword(s):  
Gene Expression ◽  
Expression Phenotype ◽  
Gene Expression Phenotype

scholarly journals A Marfan syndrome gene expression phenotype in cultured skin fibroblasts

BMC Genomics ◽  
2007 ◽  
Vol 8 (1) ◽  
pp. 319 ◽  
Author(s):  
Zizhen Yao ◽  
Jochen C Jaeger ◽  
Walter L Ruzzo ◽  
Cecile Z Morale ◽  
Mary Emond ◽  
...  
Keyword(s):  
Gene Expression ◽  
Marfan Syndrome ◽  
Skin Fibroblasts ◽  
Expression Phenotype ◽  
Cultured Skin ◽  
Gene Expression Phenotype

scholarly journals Capsaicin promotes a more aggressive gene expression phenotype and invasiveness in null-TRPV1 urothelial cancer cells

2011 ◽  
Vol 32 (5) ◽  
pp. 686-694 ◽  
Author(s):  
Sara Caprodossi ◽  
Consuelo Amantini ◽  
Massimo Nabissi ◽  
Maria Beatrice Morelli ◽  
Valerio Farfariello ◽  
...  
Keyword(s):  
Gene Expression ◽  
Cancer Cells ◽  
Urothelial Cancer ◽  
Expression Phenotype ◽  
Gene Expression Phenotype
Sign in / Sign up

Export Citation Format

Share Document