Association between miR-218 rs11134527 polymorphism and risk of selected types of cancer in Asian population: An updated meta-analysis of case-control studies

Gene ◽  
2018 ◽  
Vol 678 ◽  
pp. 370-376 ◽  
Author(s):  
Abdolkarim Moazeni-Roodi ◽  
Gholamreza Bahari ◽  
Mohsen Taheri ◽  
Hossein Ansari ◽  
Mohammad Hashemi
Keyword(s):  
Meta Analysis ◽  
Asian Population ◽  
Case Control ◽  
Case Control Studies

scholarly journals Relevance of hMLH1 -93G>A, 655A>G and 1151T>A polymorphisms with colorectal cancer susceptibility: a meta-analysis based on 38 case-control studies

2018 ◽  
Vol 64 (10) ◽  
pp. 942-951 ◽  
Author(s):  
Mohammad Zare ◽  
Jamal Jafari-Nedooshan ◽  
Mohammadali Jafari ◽  
Hossein Neamatzadeh ◽  
Seyed Mojtaba Abolbaghaei ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Susceptibility ◽  
Meta Analysis ◽  
Asian Population ◽  
Case Control ◽  
Biomedical Literature ◽  
Case Control Studies ◽  
Increased Risk ◽  
Comprehensive Search ◽  
Meta Analyses

SUMMARY OBJECTIVE: There has been increasing interest in the study of the association between human mutL homolog 1 (hMLH1) gene polymorphisms and risk of colorectal cancer (CRC). However, results from previous studies are inconclusive. Thus, a meta-analysis was conducted to derive a more precise estimation of the effects of this gene. METHODS: A comprehensive search was conducted in the PubMed, EMBASE, Chinese Biomedical Literature databases until January 1, 2018. Odds ratio (OR) with 95% confidence interval (CI) was used to assess the strength of the association. RESULTS: Finally, 38 case-control studies in 32 publications were identified met our inclusion criteria. There were 14 studies with 20668 cases and 19533 controls on hMLH1 −93G>A, 11 studies with 5,786 cases and 8,867 controls on 655A>G and 5 studies with 1409 cases and 1637 controls on 1151T>A polymorphism. The combined results showed that 655A>G and 1151T>A polymorphisms were significantly associated with CRC risk, whereas −93G>A polymorphism was not significantly associated with CRC risk. As for ethnicity, −93G>A and 655A>G polymorphisms were associated with increased risk of CRC among Asians, but not among Caucasians. More interestingly, subgroup analysis indicated that 655A>G might raise CRC risk in PCR-RFLP and HB subgroups. CONCLUSION: Inconsistent with previous meta-analyses, this meta-analysis shows that the hMLH1 655A>G and 1151T>A polymorphisms might be risk factors for CRC. Moreover, the −93G>A polymorphism is associated with the susceptibility of CRC in Asian population.

scholarly journals Association of TGF-β1 Polymorphisms with Breast Cancer Risk: A Meta-Analysis of Case–Control Studies

Cancers ◽  
2020 ◽  
Vol 12 (2) ◽  
pp. 471
Author(s):  
B. Krishna ◽  
Samir Jana ◽  
Aditya Panda ◽  
David Horne ◽  
Sanjay Awasthi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Meta Analysis ◽  
Middle Eastern ◽  
Asian Population ◽  
Case Control ◽  
Large Datasets ◽  
Case Control Studies ◽  
Middle Eastern Population ◽  
Stratified Analysis ◽  
Tgf Β1

Reports on the association of TGF-β1 polymorphisms with breast cancer (BC) have been conflicting, inconsistent, inconclusive, and controversial. PubMed, EMBASE, and Google Scholar were used to identify studies on TGF-β1 polymorphisms and BC risk. Data were extracted independently, and of the initial 3043 studies, 39 case-control studies were eligible for inclusion in the meta-analysis. Information from these studies was extracted, and the overall associations of three TGF-β1 polymorphisms (TGF-β1 29>T/C, TGF-β1-509 C/T, and TGF-β1*6A) with BC risk were analyzed using overall allele, homozygous, heterozygous, recessive, and dominant models. None of the three TGF-β1 polymorphisms studied had a significant influence on the development of BC. However, stratified analysis revealed a positive correlation between the TGF-β1 29T>C polymorphism and BC risk according to a heterozygous model of the Asian population (odds ratio (OR) = 1.115, 95% confidence interval (CI) = 1.006–1.237, p = 0.039). Interestingly, this polymorphism was associated with lower odds of BC according to a heterozygous model of the Middle Eastern population (OR = 0.602, 95% CI = 0.375–0.966, p = 0.035). Thus, our analysis of large datasets indicates that the TGF-β1 29T>C polymorphism is significantly associated with BC risk in the Asian population. In contrast, the TGF-β1*6A and TGF-β1-509 C/T polymorphisms failed to show an association with BC.

scholarly journals Case-control study of hypertension and Parkinson’s disease

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Yuen-Fann Ng ◽  
Ebonne Ng ◽  
Ee-Wei Lim ◽  
Kumar M. Prakash ◽  
Louis C. S. Tan ◽  
...  
Keyword(s):  
Case Control Study ◽  
Meta Analysis ◽  
Asian Population ◽  
Case Control ◽  
Case Control Studies ◽  
Matched Case ◽  
And Gender ◽  
Chinese Subjects ◽  
Matched Case Control Study ◽  
Control Study

AbstractWe evaluate the association of hypertension with PD in an Asian population and performed a meta-analysis on similar studies to address the effect of hypertension on PD risk. A matched case-control study involving 1342 Chinese subjects (671 PD and 671 age and gender-matched controls (with a mean age of 63.9 ± 9.7 and 63.5 ± 9.8 years, and identical proportion of gender distribution) was conducted. Hypertension increases PD risk by 1.9 times [OR 1.86 (1.46–2.38)]. The literature search identified 618 studies initially; however, only three matched case-control studies (all in Caucasians) met the inclusion criteria for meta-analysis. Overall analysis showed that hypertension decreases PD risk by 0.2 times [OR 0.80 (0.66–0.96)]. Hypertension increases PD risk by 1.9 times in our Asian population. However, a meta-analysis comprising of Caucasian populations showed a protective effect of hypertension suggesting that ethnic differences or other genetic or environmental factors may contribute to the divergent observation. Early diagnosis and treatment of hypertension may potentially reduce the risk of PD, at least in our population.

scholarly journals Association of Helicobacter pylori infection with diabetes mellitus: A Meta-analysis of Case Control Studies

2019 ◽  
Author(s):  
Kamyar Mansori ◽  
Yousef Moradi ◽  
Sara Naderpour ◽  
Roya Rashti ◽  
Ali Baradaran Moghaddam ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Systematic Review ◽  
Odds Ratio ◽  
Meta Analysis ◽  
Asian Population ◽  
Case Control ◽  
Case Control Studies ◽  
Analysis Study ◽  
Geographical Regions ◽  
H Pylori

Abstract Background Results of previous studies were showed that the association between H. pylori infection and the risk of diabetes is still controversies. Therefore, this systematic review and meta-analysis study was designed and implemented aimed to determine the association between H. pylori infection and the risk of diabetes.Methods All case control articles were searched in international databases, including Medline (PubMed), Web of sciences, Scopus, EMBASE, and CINHAL. Search was done from January 1990 to March 2019 without language limitations. Also, logarithm and standard error logarithm odds ratio (OR) were used for meta-analysis.Results A total of 41 studies were included in this meta-analysis. The range of association with odds ratio in case control studies which published between 1990 to 2019 was 0.21 to 6.08. The pooled estimate of the association between H. pylori infection with diabetes was 1.27 (95% CI 1.11 to 1.45, P = 0.0001, I 2 = 86.6%). The effect of H. pylori infection on diabetes mellitus, type 1 and type 2 diabetes was 1.17 (95% CI 0.94 to 1.45), 1.19 (95% CI 0.98 to 1.45), and 1.43 (95% CI 1.11 to 1.85) respectively. Subgroup analysis by the geographical regions showed in Asian population risk of the effect of H. pylori infection on diabetes was higher than other population, but in the American, this was a protective relationship.Conclusion In conclusion, this systematic review & meta-analysis study suggested that H. pylori infection was associated with the risk of diabetes as compared to non- diabetes individual.

scholarly journals Quantitative assessment of the association between GRIA1 polymorphisms and migraine risk

2018 ◽  
Vol 38 (6) ◽  
Author(s):  
Xueren Gao ◽  
Jianguo Wang
Keyword(s):  
Fixed Effects ◽  
Meta Analysis ◽  
Asian Population ◽  
Pooled Analysis ◽  
Case Control ◽  
Large Sample Size ◽  
Fixed Effects Model ◽  
Case Control Studies ◽  
Knowledge Infrastructure ◽  
Online Databases

Purpose: The association between GRIA1 rs548294 G>A and rs2195450 C>T polymorphisms and migraine risk has been reported in several case–control studies. However, the results of studies are inconsistent. Thus, we conducted a meta-analysis to more precisely estimate the association of the two polymorphisms with migraine risk. Methods: Eligible studies were retrieved and screened from the online databases (EMBASE, PubMed, Web of Science, Wanfang, and Chinese National Knowledge Infrastructure). The pooled odds ratio (OR) with corresponding 95.0% confidence intervals (CIs) was assessed using random- or fixed-effects model. Results: A total of 1233 cases and 1374 controls from four eligible studies were included. The pooled analysis showed that GRIA1 rs548294 G>A polymorphism was not significantly associated with migraine risk. GRIA1 rs2195450 C>T polymorphism was significantly associated with migraine risk under heterozygous model (CT vs. CC, OR = 1.23, 95%CI = 1.02–1.48, PZ = 0.03). Further subgroup analysis based on ethnicity showed a significant association of GRIA1 rs2195450 C>T polymorphism with migraine risk in Asian population, but not in Caucasian population. Conclusions: Our results indicates that GRIA1 rs2195450 C>T polymorphism is significantly associated with migraine risk. However, the number of studies included in the meta-analysis was small. Thus, more high quality case–control studies with a large sample size are still required to confirm these findings.

scholarly journals Helicobacter pylori infection as a risk factor for diabetes: A Meta-analysis of Case-Control Studies

2020 ◽  
Author(s):  
Kamyar Mansori ◽  
Yousef Moradi ◽  
Sara Naderpour ◽  
Roya Rashti ◽  
Ali Baradaran Moghaddam ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Odds Ratio ◽  
Meta Analysis ◽  
Asian Population ◽  
Positive Association ◽  
Case Control ◽  
Case Control Studies ◽  
Geographical Regions ◽  
H Pylori ◽  
And Control

Abstract Background There are several studies with varied and mixed results about the possible relationship between H. pylori and diabetes. Therefore, this current meta-analysis performed to determine the association between H. pylori infection and the risk of diabetes mellitus. Methods A systematic literature searches of international databases, including Medline (PubMed), Web of Sciences, Scopus, EMBASE, and CINHAL (January 1990–March 2019) was conducted to identify studies investigating the relationship between H. pylori infection and diabetes mellitus. Only case–control studies were analyzed using odds ratio (OR) with 95 % confidence intervals (CIs). Stratified and subgroup analyses were performed to explore heterogeneity between studies and assess effects of study quality. Logarithm and standard error logarithm odds ratio (OR) were also used for meta-analysis. Results A total of 41 studies involving 9559 individuals (case; 4327 and control; 5232) were analyzed. The pooled estimate of the association between H. pylori infection with diabetes was OR=1.27 (95% CI 1.11 to 1.45, P = 0.0001, I2 = 86.6%). The effect of H. pylori infection on diabetes mellitus (both types), type 1 and type 2 diabetes was 1.17 (95% CI 0.94 to 1.45), 1.19 (95% CI 0.98 to 1.45), and 1.43 (95% CI 1.11 to 1.85) respectively. Subgroup analysis by the geographical regions showed in Asian population risk of the effect of H. pylori infection on diabetes was slightly higher than other population.Conclusion In overall a positive association between H. pyloriinfection and diabetes mellitus was found.

Meta-Analysis of Case-Control and Family-Based Associations Between the 5-HTTLPR L/S Polymorphism and Susceptibility to ADHD

2015 ◽  
Vol 22 (9) ◽  
pp. 901-908 ◽  
Author(s):  
Young Ho Lee ◽  
Gwan Gyu Song
Keyword(s):  
Transmission Disequilibrium Test ◽  
Odds Ratio ◽  
Meta Analysis ◽  
Asian Population ◽  
Case Control ◽  
Case Control Studies ◽  
Polymorphic Region ◽  
S Allele ◽  
Family Based ◽  
Study Participants

Objective: The aim of this study was to determine whether the serotonin transporter-linked polymorphic region (5-HTTLPR) L (long)/S (short) polymorphism is associated with susceptibility to ADHD. Method: We conducted a meta-analysis of case-control associations and the transmission disequilibrium test (TDT) between the 5-HTTLPR L/S polymorphism and ADHD. Results: A total of 19 comparison studies were included in this meta-analysis. Our meta-analysis of the case-control studies showed no association between ADHD and the 5-HTTLPR S allele, for all study participants (odds ratio [OR] = 1.075, 95% confidence interval [CI] = [0.990, 1.167], p = .085), or for the European or Asian population. The TDT indicated no association between ADHD and the 5-HTTLPR S allele, for all study participants (OR = 1.078, 95% CI = [0.962, 1.207], p = .196). Conclusion: This meta-analysis of case-control studies and TDT showed a lack of association between the 5-HTTLPR L/S polymorphism and ADHD.

scholarly journals A meta-analysis of serum osteocalcin level in postmenopausal osteoporotic women compared to controls

2019 ◽  
Vol 20 (1) ◽  
Author(s):  
Zhongyu Liu ◽  
Ruiqiang Chen ◽  
Yutong Jiang ◽  
Yang Yang ◽  
Lei He ◽  
...  
Keyword(s):  
Bone Turnover ◽  
Subgroup Analysis ◽  
Meta Analysis ◽  
Asian Population ◽  
Case Control ◽  
Cochrane Library ◽  
Case Control Studies ◽  
Significant Difference ◽  
High Bone ◽  
Study Population

Abstract Background Circulatory osteocalcin (OC) has been widely used as a biomarker to indicate bone turnover status in postmenopausal osteoporosis (PMO). However, the change of serum OC (sOC) level in PMO cases compared to postmenopausal controls remains controversial. Methods We searched the online database of PubMed and Cochrane Library. A meta-analysis of case-control studies was performed to compare the pooled sOC level between PMO patients and postmenopausal controls. Subgroup analysis according to potential confounding factors (different OC molecules and regions of the study population) was also performed. Results Ten case-control studies with 1577 postmenopausal women were included in this meta analysis. We found no significant difference in the pooled sOC level [mean difference (MD) = 1.84, 95% confidence interval (CI): (− 1.49, 5.16), p = 0.28] between PMO patients and controls. Subgroup analysis also revealed no significant difference in intact OC [MD = 1.76, 95%CI: (− 1.71, 5.23), p = 0.32] or N-terminal mid-fragment of the OC molecule [MD = 0.67, 95%(− 5.83, 7.18), p = 0.84] between groups. For different regions, no significant difference in sOC was found in Asian population between cases and controls [MD = -0.06, 95%(− 6.02, 5.89), p = 0.98], while the pooled sOC level was significantly higher in European PMO cases than controls [MD = 3.15, 95%(0.90, 5.39), p = 0.006]. Conclusions Our analysis revealed no significant difference in sOC level between PMO cases and controls according to all the current eligible studies. OC molecules are quite heterogeneous in the circulation and can be influenced by glucose metabolism. Therefore, sOC is currently not a good indicator for the high bone turnover status in PMO. More trials with standardized methodologies for the evaluation of circulatory OC are awaited to update our current findings.

scholarly journals Association between a DJ-1 polymorphism and the risk of Parkinson's disease: a PRISMA-compliant systematic review and meta-analysis

2020 ◽  
Vol 48 (8) ◽  
pp. 030006052094794
Author(s):  
Jie Liu ◽  
Chunrong Li ◽  
Xiaoyang Zhou ◽  
Jian Sun ◽  
Meng Zhu ◽  
...  
Keyword(s):  
Systematic Review ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Web Of Science ◽  
Meta Analysis ◽  
Asian Population ◽  
Case Control ◽  
Gene Variants ◽  
Case Control Studies ◽  
The Relationship

Objective In recent years, a number of case–control studies have focused on the association between the DJ-1 g.168_185del polymorphism and the risk of Parkinson's disease (PD). However, the results have been conflicting. To estimate the relationship between the DJ-1 g.168_185del polymorphism and PD susceptibility, a comprehensive meta-analysis was performed. Methods Eligible studies concerning the DJ-1 g.168_185del polymorphism and PD susceptibility were searched for in the PubMed, Web of Science, Embase, Wanfang, CNKI, and VIP databases. Odds ratios and 95% confidence intervals were calculated to estimate the strength of the associations. In total, 11 studies were included in this meta-analysis, including 13 case–control studies with 2890 cases and 3043 controls. Results This meta-analysis revealed that DJ-1 g.168_185del variants are associated with PD susceptibility in the non-Asian population, but not in the Asian population. Conclusions Our meta-analysis suggests that DJ-1 gene variants are not associated with the risk of PD in the overall population.

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