A retrospective pilot study of preoperative mobilization program for older adults with hip fracture

2021 ◽  
Vol 42 (4) ◽  
pp. 908-914
Author(s):  
Jiaxin Liu ◽  
Li Chen ◽  
Cheng Long ◽  
Xiang Zhang ◽  
Feng Gao ◽  
...  
Keyword(s):  
Older Adults ◽  
Hip Fracture ◽  
Pilot Study

Community Exercise Program for Older Adults Recovering from Hip Fracture: A Pilot Study

2006 ◽  
Vol 14 (4) ◽  
pp. 439-455 ◽  
Author(s):  
Gareth R. Jones ◽  
Jennifer M. Jakobi ◽  
Albert W. Taylor ◽  
Rob J. Petrella ◽  
Anthony A. Vandervoort
Keyword(s):  
Physical Activity ◽  
Older Adults ◽  
Hip Fracture ◽  
Pilot Study ◽  
Lower Extremity ◽  
Effective Means ◽  
Exercise Program ◽  
Knee Extensor ◽  
Community Dwelling ◽  
Functional Mobility

Community-based rehabilitative exercise programs might be an effective means to improve functional outcomes for hip-fracture patients. The purpose of this study was to evaluate the effectiveness of a community exercise program (CEP) for older adults recovering from hip fracture. Twenty-five older adults (mean age 80.0 ± 6.0 years; 24 women; 71 ± 23 days post–hip fracture) participated in this pilot study (17 exercise, 8 control). The CEP involved functional stepping and lower extremity–strengthening exercises. Control participants received only standard outpatient therapy. Measures of functional mobility, balance confidence, falls efficacy, lower extremity strength, and daily physical activity were evaluated at baseline and at 16 weeks. Improvements for self-reported physical activity, mobility, balance, and knee-extensor strength were observed for the CEP group. This study demonstrated that a CEP is beneficial for community-dwelling older adults post–hip fracture.

scholarly journals A pilot study examining the impact of exercise training on skeletal muscle genes related to the TLR signaling pathway in older adults following hip fracture recovery

2017 ◽  
Vol 122 (1) ◽  
pp. 68-75 ◽  
Author(s):  
Alec I. McKenzie ◽  
Robert A. Briggs ◽  
Katherine M. Barrows ◽  
Daniel S. Nelson ◽  
Oh Sung Kwon ◽  
...  
Keyword(s):  
Gene Expression ◽  
Older Adults ◽  
Skeletal Muscle ◽  
Hip Fracture ◽  
Pilot Study ◽  
Exercise Training ◽  
Muscle Function ◽  
Tlr Signaling ◽  
Hip Fracture Surgery ◽  
Fracture Surgery

Older adults after hip fracture surgery experience progressive muscle atrophy and weakness, limiting full recovery. Further understanding of the molecular mechanisms in muscle with adaptation to exercise training in this vulnerable population is necessary. Therefore, we conducted a pilot study to investigate the skeletal muscle inflammatory and ceramide biosynthesis gene expression levels associated with the toll-like receptor (TLR) pathway before (Pre) and following a 3-mo multicomponent exercise training program in older adults (3M, 4F; 78.4 ± 13.3 yr; 25.5 ± 2.3 kg/m2) ~4 mo after repair from hip fracture (HipFx). Vastus lateralis biopsies from the surgical limb were obtained before (Pre) and after training. Molecular end points and muscle function data were also compared with matched nonexercise healthy controls (CON). As a follow-up analysis, we evaluated specific sphingolipid pools in HipFx and CON muscle. Following training, quadriceps cross-sectional area, strength, and 6-min walk (6MW) increased in the surgical limb ( P < 0.05). Additionally, MYD88, TAK1, NFKB1, IL6, SPT2, and CERS1 gene expression decreased after training ( P ≤ 0.05), but some remained elevated above CON levels. Interestingly, MYD88 mRNA was inversely correlated to quadriceps CSA, strength, and 6MW. Finally, muscle dihydroceramides and phosphoceramides in HipFx were lower than CON at Pre ( P ≤ 0.05), but after training differences from CON were removed. Together, our pilot data support that exercise training alters skeletal muscle inflammation and ceramide metabolism associated with TLR signaling in older adults recovering from hip fracture surgery and may be related to improvements in muscle function recovery. NEW & NOTEWORTHY These pilot data demonstrate that 3 mo of exercise training in older adults recovering from hip fracture surgery was able to mitigate skeletal muscle gene expression related to inflammation and ceramide metabolism while also improving surgical limb lean tissue, strength, and physical function.

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